DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DLG5 and dlg5

DIOPT Version :9

Sequence 1:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens
Sequence 2:	XP_004916076.1	Gene:	dlg5 / 779611	XenbaseID:	XB-GENE-978275	Length:	1971	Species:	Xenopus tropicalis

Alignment Length:	2038	Identity:	1227/2038 - (60%)
Similarity:	1493/2038 - (73%)	Gaps:	192/2038 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLD--EEAGGAKAELLLKLLLAK 63
            |||:.||||.:|.::|.:::::.:.:|.:||.||||:..:|.:||  ..:|..|.:||||:||.|
Frog     1 MEPKHRELLKKCHKNLTESISDADRLLNVLEEAGALTIRDREELDGSSSSGQEKVDLLLKMLLVK 65

Human    64 ERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLSSVGTTG 128
            |:|||||||.|||||:||||.||||||:    ...:.||||||||:|||||||||.||||:|||.
Frog    66 EKDHFQDLRVALEKTEPHLLSILYLNGL----GTGDTAGSTYSVLTTMPSDSESSGSLSSIGTTN 126

Human   129 KAPSPPPLLTDQ-QVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDK-RPYHRLNPDYERL 191
            |..||||...|. |||||:|.:..|||.:||||:|||||||.::.|:.||. |...:|.||||||
Frog   127 KPSSPPPTAADSLQVNEKIETILSQLRQVTRERDELRKRLALSSPGSTFDDCRSSPKLTPDYERL 191

Human   192 KIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLR 256
            |:||::|||:|::||:||..|||:|||.|||.||||.||||:|||.|:|::|.:.:||.:.||.|
Frog   192 KVQCMKAMSELEALQSQHAKALKKCEEAAKEADFYHALHSRMLSDHTQLQEDSESMRRNHAQLQR 256

Human   257 ERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALR 321
            |.:.||||.:|:|.|||.||.|:.:||.|||.|:|.|||||::||||:||:||||.||||||:||
Frog   257 EFSHLQQSCQDLKHLHETDQLEMSELRRQQQLVVKQNGSSELINKLYNTALDKLEGVKKDYDSLR 321

Human   322 KRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKA 386
            ::|:|||:.||.||.||||..||.:.|.||.|.|.:||:.||..|||.:.|:||:::|..||||.
Frog   322 RQYNEKVSSHNLDLGRLEQSEEEKRSLQKQLEGLLKQRENAIHFQHQFSSSMRRYDSIQQELNKV 386

Human   387 TAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQT 451
            |.|||:||.|||.||:|.|..:|.|:|.:||:|||:||||:|::||:||||||||||.|:||:||
Frog   387 TLQNKELQREMERLQAEATRFKTMQLKASKEAEKYKEERDSVFNEYRLIMSERDQVIKEMDKMQT 451

Human   452 EVELAESKLKSSTSEKKAANEEMEAL--------------------------------------- 477
            |:|||:.:||:::|||:.|:||||||
Frog   452 ELELAQGRLKNTSSEKRVASEEMEALRQELNSALVERDRSIFERNELLEKYCHEVKDKAEAQKEL 516

Human   478 --------------------------------------RQIKDTVTMDAGRANKEVEILRKQCKA 504
                                                  |||:|:.|:|..|||||:|:||||.:|
Frog   517 DQACKDIETVKEERDVARKERTEAIIQRDHLLREYYQARQIQDSATLDMERANKEIEVLRKQYEA 581

Human   505 LCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTR 569
            :..|||||.|||:||||||||||||||||||||:|||||||||||||||||||||||||:|||.|
Frog   582 MSHELKEATQEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSELAEALRNLDDMR 646

Human   570 KQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKA 634
            |||||.|||||||||:|::|:|||||||||||||||||||||||:|||||||||||:.||:||||
Frog   647 KQKNDASRELKELKEKMDNQMEKEARFRQLMAHSSHDSAIDTDSLEWETEVVEFERDREDMDLKA 711

Human   635 LGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGE 699
            ||||:|:|||||.|||:..||||||||||||||||||||.||:||||||.|||:||.:||:|:|.
Frog   712 LGFDVADGVNEPLFPGESCIFVTKVDKGSIADGRLRVNDCLLKINDVDLANKDRKQLLKAVLSGG 776

Human   700 GAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAI 764
            ..||||:|||||||.:::|||||:|..|||||||||:||..:||:|||||||||||..|||:|.|
Frog   777 EVINMVIRRRKSLGNRIITPLHIHLGSQKDSGISLESGVLVSAVVPGSPAAKEGSLVAGDRVVTI 841

Human   765 NGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQA 829
            |||:|||||:.|||:|||:||:||.||||||.|.::||||||:|||:|:|..:||     |.:.|
Frog   842 NGISLDNKSVMECEALLRNCQESLNLSLLKVVPPNTSWSGQNLFENLKESCHVLS-----PNIHA 901

Human   830 HNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSS 894
            .||||| ::|:|||||||..|.||.:|..|...||...|.            .:|.|.||.||||
Frog   902 QNKRNL-KNNSSTQTDIFNPDILECKKNMGDRTGSERALQ------------LSCHSHSEHSLSS 953

Human   895 FRSDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEASLDK--ADSEGSNSGGTWPKAMLSSTAV 957
            ...:....:|:.::|..|.           |.|..:...|.  ..:.|..|.|||||.|:|....
Frog   954 LGGEVFMGQGYDILDDGGH-----------PLGFADTMEDNLVETATGKRSSGTWPKVMVSPGHS 1007

Human   958 PEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSI 1022
            ..:.:|:|||:.|||||||:|||||||||||.:|.|.....|||||||...|.|||.||:|||||
Frog  1008 QGEFTVFKKPRHRKSIFDPDTFKRPQTPPKISFLPPVQVLGHSPQPSKTERPPTPPTPPKRSDSI 1072

Human  1023 KFQHRLETSSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSH 1087
            ||:||.::||.|::|:...||.|||        .|| |:.|....||.                |
Frog  1073 KFKHRHQSSSASDSTVTAGSPPTSP--------SPG-PLPAETSHKAH----------------H 1112

Human  1088 LPAKKSC------DEDLTS-----------QKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEE 1135
            ..|..||      |..||.           |:.:|...||.||:|||:.|.:||||:||...|
Frog  1113 SRAIGSCCREDGIDCPLTGCIGTGDVEGCLQRAEEPELKRARPRSAPALRHRLAPVLIPHYAL-- 1175

Human  1136 QKCVPASGE-LSPEL-QEWAPYSPGHSSRHSN---PPLYPSRPSVGTVPRSLTPSTTVSSILRNP 1195
            ||....|.| ||||| .:|..:||..|.|||:   ..:|....| |||||||.|...|:::||||
Frog  1176 QKFSMNSEERLSPELAHDWIRFSPTRSPRHSDIFAASMYGPGMS-GTVPRSLAPCPAVTAVLRNP 1239

Human  1196 IYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDY---SEMRATHGSNSLPS 1257
            |||..||||...:.|.:|.....|.||.|.||.||||||||::..:::   |..|..||||||||
Frog  1240 IYTAWSHRVPSNNCPSSANQICQQHLHSSAQHHGRLSLDLSNKHPNEFCDTSRSRVPHGSNSLPS 1304

Human  1258 SARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECS-----TPPQSPLNIDTLS-SCS 1316
            |||||||     :.||||||||||||||.|||:|||:||||||     :||.||||::|.| :.|
Frog  1305 SARLGSS-----RTERIKIPSTPRYPRSSVGSDRGSLSHSECSSPSLASPPHSPLNLETSSFASS 1364

Human  1317 QSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTVGS 1381
            |||:|.::||||:|:...:||||||||.||||||||||||||||||||..||.|||:|||||.||
Frog  1365 QSQSSVASLPRISVSTVPIGERRKDRPLVEEPRHVKVQKGSEPLGISIGGGESGGIFVSKVTTGS 1429

Human  1382 IAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDP 1446
            ||.|||||||||||||||||||:|||||||||||||||||||||||||::.| ..||||||.||.
Frog  1430 IAQQAGLEYGDQLLEFNGINLRNATEQQARLIIGQQCDTITILAQYNPNMCQ-HIHSRSSSRLDT 1493

Human  1447 AGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQ--------SSSRIAGDANKKTLEPRVV 1503
            :.||||...||..||::.|:||.:.|||||..|||:|:        ||.|...:..|:..|.|||
Frog  1494 STTHSTPHSSGAATPDNHSIIDTVSEQDEGTMTPPSKESTPSTSPCSSLRTNAEGIKRHSELRVV 1558

Human  1504 FIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEML 1568
            .:.||..:||:.:|||||||:||.::|:::..   .||:.||::|||||:|:||:|.||.|:|||
Frog  1559 TLSKSPEKLGIQICGGNLHGIFVLDIEEENVV---GGLLKGDMVLEYGSVDMRNRTAEEAYLEML 1620

Human  1569 KPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQELSFKKDDILYVDDTLPQGTFGS 1633
            ||.:.:::|||.:.:||.|.|.||||.|||||||||.|::..||||||||||||||||||||||:
Frog  1621 KPAENIKVKVQQKIDEFNKLKDLPGDGFYIRALYDRQAELPSELSFKKDDILYVDDTLPQGTFGT 1685

Human  1634 WMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRS 1698
            ||||||||||||:||||:||||:|:|||||||||||.:|:..|:|||||||||||||||:|||||
Frog  1686 WMAWQLDENAQKLQRGQVPSKYMMEQEFSRRLSMSEGRDETMASKTLSAAARRSFFRRKNKHKRS 1750

Human  1699 GSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGK 1763
            ||:|||||..||..|:||||..::||||||||||:||||:.|||||||||:|.||:|||.|:|||
Frog  1751 GSRDGKDLQGLDTISTDSIPFLDESVSLAYQRVQRVDCTSPRPVLILGPLVDAVKDMLVKESPGK 1815

Human  1764 FCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERL 1828
            |||||||||||||||||||||||||:|||||||||||||||||||||||:.||||||||||||||
Frog  1816 FCRCPLEVMKASQQAIERGVKDCLFIDYKRRSGHFDVTTVASIKEITEKDCHCLLDIAPHAIERL 1880

Human  1829 HHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGAL 1893
            |.:||||||:||.|||.|.||||:|||:|||||||:|||||||.|.|:|||||:|||.|||||||
Frog  1881 HSVHIYPIVLFIRYKSTKQIKEQKDPIFLRDKVTQKHSKEQFETAHKIEQEYSKYFTAVIQGGAL 1945

Human  1894 SSICTQILAMVNQEQNKVLWIPA 1916
            .|||.||.::|:|||:|.|||||
Frog  1946 FSICNQICSIVDQEQSKALWIPA 1968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142		30/44 (68%)
		Takusan	130..212	CDD:282652	47/83 (57%)
		TPR_MLP1_2	231..353	CDD:285204	73/121 (60%)
		COG1340	295..587	CDD:224259	202/368 (55%)
		FliJ	310..449	CDD:304890	84/138 (61%)
		BAR	417..601	CDD:299863	141/260 (54%)
		PDZ_signaling	620..707	CDD:238492	66/86 (77%)
		DegQ	<702..771	CDD:223343	50/68 (74%)
		PDZ_signaling	722..790	CDD:238492	49/67 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		89/213 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		17/39 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		12/28 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		14/18 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		28/39 (72%)
		PDZ	1347..1429	CDD:214570	74/81 (91%)
		dbPDZ_assoc	1427..1499	CDD:293216	36/79 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		31/66 (47%)
		PDZ	1499..1582	CDD:214570	42/82 (51%)
		SH3_DLG5	1597..1659	CDD:212794	52/61 (85%)
		GuKc	1732..1908	CDD:214504	144/175 (82%)
		Guanylate_kin	1740..1907	CDD:279019	138/166 (83%)
dlg5	XP_004916076.1	CARD	9..88	CDD:260018	39/78 (50%)
		Takusan	127..213	CDD:368141	48/85 (56%)
		Smc	<136..544	CDD:224117	207/407 (51%)
		COG4372	443..>672	CDD:226809	115/228 (50%)
		PDZ_signaling	697..784	CDD:238492	66/86 (77%)
		PDZ_signaling	798..867	CDD:238492	50/68 (74%)
		PDZ	1395..1477	CDD:214570	74/81 (91%)
		dbPDZ_assoc	1475..1554	CDD:374667	36/79 (46%)
		PDZ	1554..1633	CDD:214570	42/81 (52%)
		SH3_DLG5	1649..1711	CDD:212794	52/61 (85%)
		GuKc	1784..1960	CDD:214504	144/175 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I4834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3486
Inparanoid	1	1.050	2039	1.000	Inparanoid score	I641
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47148
OrthoDB	1	1.010	-	-		D10159at7742
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		oto153823
Panther	1	1.100	-	-	LDO	PTHR46360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080