DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DLG5 and CG15803

DIOPT Version :9

Sequence 1:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	1145	Identity:	230/1145 - (20%)
Similarity:	378/1145 - (33%)	Gaps:	352/1145 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   613 SMEW-ETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDW 674
            |.|| :.||::...     |...|||.:..|       ...|:.:..:..|.:|  ||||::.|.
  Fly     4 STEWSQVEVIDLIN-----DGNGLGFILVGG-------RSTGVVIKALTPGGVAERDGRLQLGDH 56

Human   675 LLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHIN---------------L 724
            ||:|.:|:|.....:|....|......:.::|.|       .|.|..|:               |
  Fly    57 LLQIGEVNLRGFSSEQVATVLRQTGAQVRLIVAR-------PVEPTAIDYQTLACQAPIIPTKLL 114

Human   725 SGQKDSGISL-ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLR-SCQDS 787
            |..::....| :|..:|.|.:..:.||...:.:..|..|...|: ||..||   ..|:| ...:.
  Fly   115 SDPEELSRHLFQNPSFATAAVAAAAAAAAAAGSGSDGDVGGGGV-LDVASL---VGLVRGGPAEG 175

Human   788 LTLSLLKVFPQSSSWSGQNIFENIKD-SDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDR 851
            ..||.::..|.::....|.:.|...| :|..|      |.:......:::..:|:.|..   ..|
  Fly   176 TELSAVEPQPSAAVLQLQQLSELAGDLADFPL------PPIPGGGGHSMVTDSNAGQRP---CPR 231

Human   852 LEDRKEPGPPGGSSSFLHKPFPGGPLQVCP----QACPSASERSLSSFRSDASGDRGFGLVDVRG 912
            |:....|      .|.|..| |...||:.|    ..|.....|.:.:..:|:
  Fly   232 LDLDIVP------FSILSPP-PRPALQMLPLETQWRCVQDQNRHIETVIADS------------- 276

Human   913 RRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPE-KLSVYK----------K 966
            :|.||..|..      |.||     :.||.|..::..:..:.|.|.| ..:||.          :
  Fly   277 KRKLLANEDG------GSAS-----ASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCE 330

Human   967 PKQRKSIFDPNTFK--RPQTPPKI---DYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSI---- 1022
            .:....||..:..:  ..:|..:|   |.::...|.:.|...:.:|..|.     |.:|.:
  Fly   331 EEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELL-----RNTDIVVHLT 390

Human  1023 --------KFQHRLETSSESEATLVGSSPSTSPPSAL--PPDVDPGEPMHASPPRKARVRIASSY 1077
                    |::|.....:|.:        .||.||.|  ..|.|..:....|.|....:...|..
  Fly   391 LERFLRGRKYEHLQVALTEIK--------GTSAPSGLDRSQDKDQDQESQLSMPGSPSIATLSWL 447

Human  1078 YPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPAS 1142
            .|            ||.|.|..:.:.||                     .:.|::      |..|
  Fly   448 PP------------KSLDADSIATEGDE---------------------AVDAEY------VGIS 473

Human  1143 GELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPC 1207
            |.....::                  .|||.:|         .:.:|.:|.      ||...|..
  Fly   474 GAEDEFIE------------------LPSRDTV---------ESNMSHVLD------RSDHSGGL 505

Human  1208 SSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAE 1272
            :     :|..|: :.|.|......||.|:..:.:|..|..|...:.:  :.||.||..    :.|
  Fly   506 T-----KDQVPR-ISPIVPLTNGRSLILADDSGNDTDEQCAEPETET--AQARKGSKP----ETE 558

Human  1273 RIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGE 1337
            |:|                 .:..::..|.|...|:      ..|..|..:..|..|.:|.:
  Fly   559 RVK-----------------DLGDTKTDTDPDPDLD------PGQMPTPTNEAPVKAASPTA--- 597

Human  1338 RRKDRPYVEEPRHVKVQKGSEPLGISI---VSGEKG-----GIYVSKVTV-GSIAHQAGLEYGDQ 1393
                         ..::...:.||||:   |..|.|     ..|:..:.. |.:..|..|..||:
  Fly   598 -------------ASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQGILRPGDE 649

Human  1394 LLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGT 1458
            ||:.|...|:..          :..:.:.||.:....|..:.:.          |||.
  Fly   650 LLQVNEHKLQGL----------RHIEVVKILKELPARVKLVCAR----------GTHV------- 687

Human  1459 TTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHG 1523
                 ||||:.       ...|.|.::.|.:.|  ..::|:.   .:.|:|.|       .:|:.
  Fly   688 -----PSVINT-------SQNPEAFETRSLLPG--GHQSLQN---LLSKAQSE-------SSLYT 728

Human  1524 VFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEV-----------YVEMLKPRDGVRLK 1577
            ...|.:.|...|.|..|...|.        ..|:|::|.|           .|::.|...|....
  Fly   729 SSTATLTDAGAAAGGSGGTAGG--------GARSKSLENVSGLALWSCEVTAVDIEKTEQGFGFS 785

Human  1578 VQYRPEEFTKAKGLPGDSFYIRALY-DRLADVEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDE 1641
            :.    ::.......|....||.|. ...|:...|: :..|.::.|.|.|.||.       :|||
  Fly   786 IL----DYQDPLDSEGSVIVIRGLIRGGAAEATNEI-YPGDRLMSVGDRLLQGL-------ELDE 838

Human  1642 NAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLS 1681
             |..|.:...|.  :......|.||.|   |.||.:...|
  Fly   839 -AVSILKAMPPG--LTRLGICRPLSAS---DSNSNSNIAS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492	21/88 (24%)
		DegQ	<702..771	CDD:223343	17/84 (20%)
		PDZ_signaling	722..790	CDD:238492	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		42/224 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		4/36 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		5/34 (15%)
		PDZ	1347..1429	CDD:214570	19/90 (21%)
		dbPDZ_assoc	1427..1499	CDD:293216	12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		11/58 (19%)
		PDZ	1499..1582	CDD:214570	17/93 (18%)
		SH3_DLG5	1597..1659	CDD:212794	17/62 (27%)
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	20/83 (24%)
		PDZ	307..393	CDD:214570	16/90 (18%)
		PDZ_signaling	605..680	CDD:238492	20/84 (24%)
		PDZ	773..858	CDD:214570	21/99 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900