DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DLG5 and dlg1

DIOPT Version :9

Sequence 1:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens
Sequence 2:	NP_001162718.1	Gene:	dlg1 / 32083	FlyBaseID:	FBgn0001624	Length:	1030	Species:	Drosophila melanogaster

Alignment Length:	980	Identity:	205/980 - (20%)
Similarity:	348/980 - (35%)	Gaps:	258/980 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   273 EEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSR 337
            ||:.:|...|..|::..::.:.....|..|...:.:.:||.::..|......:.|.:..:.|
  Fly    43 EEEPEEEECLLPQKKAQIRCDQDQPPLVVLVQPSAEAIEVRQEIDDTNPVAVAAKASDMDGD--- 104

Human   338 LEQLGEENQRLLKQTEMLTQQRDTAIQLQHQ---CALSLRRFEAIHHELNKATAQNKDLQWEMEL 399
                        .|.|::..|.:|..:...:   |..|||  :::...: :.....:||.....:
  Fly   105 ------------SQLEVMEHQMETVTEPDPEPPKCPTSLR--DSVRESV-ECFYSAQDLLEYGHM 154

Human   400 LQSELTELRTTQVKTAKESEKY--REERDAVYSEYK--------------------LIMSERDQV 442
            |.|      |:.|:|......|  :.|.||...|::                    |.:|...:.
  Fly   155 LSS------TSMVRTPDVESGYFEKSESDASRDEWEGPSSSSSGAARCRLLSGISGLSVSSSSRH 213

Human   443 ISE--------------------LDKLQTEVEL-AESKLKSSTSEKK----AANE---EMEALRQ 479
            .:|                    |:|.|:|::| |:||.|....::.    ||.|   |..:.|.
  Fly   214 SAEGLRMELSRFRTMIETLERESLEKSQSELQLKAKSKAKPKPKQRSHVQDAAGESGSEQGSERG 278

Human   480 IKDTVTMDAG---------------RANKEVEILRKQCKALCQELKEALQEA--DVAKCRRDWAF 527
            ...|:...||               :|::.:|:|......|.:....||:.|  .|.:..:...|
  Fly   279 FWSTIFGQAGLAISQDEEERIADIQKAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLF 343

Human   528 QE-------------RDKIVAERDSIRTLCDNLRRERDRAVSELA--EALRSLDDTRKQKN-DVS 576
            |.             .|....::.:..||....:.|:|....::|  :.:|...||...|. .|.
  Fly   344 QALLDIQEFYELTLLDDSKSIQQKTAETLQIATKWEKDGQAVKIADNQRMRIESDTENAKEPTVE 408

Human   577 RELKELKEQMESQLEKEARFRQLMAHSSHDSAIDT----DSMEWETEVVEFERETEDIDLKALGF 637
            ::.|:.:.|..|....:.:..|....|...|...|    ||  |..|.::.||..     ..|||
  Fly   409 QQQKQQQAQQRSSRSPQQQNPQQQQGSKSRSGSQTVNGDDS--WLYEDIQLERGN-----SGLGF 466

Human   638 DMAEGVNEPCFPGDCGIFVTKVDKG--SIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEG 700
            .:|.|.:.|....|..|::||:..|  :.|||||.:||.::.:|||.:::.....|:.||.....
  Fly   467 SIAGGTDNPHIGTDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGN 531

Human   701 AINMVVRRRKSLGGKVVTP-------------------LHINL-SGQKDSGISL----------- 734
            .:.:.|:|::   |...||                   :.|:| .|.|..|.|:
  Fly   532 VVKLHVKRKR---GTATTPAAGSAAGDARDSAASGPKVIEIDLVKGGKGLGFSIAGGIGNQHIPG 593

Human   735 ENGVYAAAVLPGSPAAKEGSLAVGDRIVAI--NGIA--LDNKSLNECESLLRSCQDSLTLSLLKV 795
            :||:|...::.|..|..:|.|::||:::|:  ||..  |:|.:.....:.|:|..|.:||.:.|.
  Fly   594 DNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKT 658

Human   796 FPQSSSWS-----GQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDR 855
            ...::|.|     |.:..:.:..|...|:  ....:.|.|.:::.....||..|
  Fly   659 QHLTTSASGGGGGGLSSGQQLSQSQSQLA--TSQSQSQVHQQQHATPMVNSQST----------- 710

Human   856 KEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRRPLLPFE 920
             |||....|::.|....||.|                          |.....|:. |.| ....
  Fly   711 -EPGSRYASTNVLAAVPPGTP--------------------------RAVSTEDIT-REP-RTIT 746

Human   921 TEVGPCGVGEASLDKADSEGSN-----SGGTWPKAMLSSTAVPEKL-SVYKKPKQRKSIFDPNTF 979
            .:.||.|:|...:...|.:|..     :||            |..| |..|:..|..|:.:.|
  Fly   747 IQKGPQGLGFNIVGGEDGQGIYVSFILAGG------------PADLGSELKRGDQLLSVNNVN-- 797

Human   980 KRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSI-KFQHRLETSSESEATLVGSSP 1043
                        |.......:.|..|.:|.:.......|.:.. :|:.|::...:..|...|.|
  Fly   798 ------------LTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAGGS- 849

Human  1044 STSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDG--DSSHLPAKKSCDEDLTSQKVDEL 1106
                          |..:..:..|...||....|.|..|.  .|..||.|......:|:...||.
  Fly   850 --------------GTLLRTTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEW 900

Human  1107 GQKRR 1111
            .|.||
  Fly   901 WQARR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204	13/79 (16%)
		COG1340	295..587	CDD:224259	70/377 (19%)
		FliJ	310..449	CDD:304890	29/183 (16%)
		BAR	417..601	CDD:299863	50/266 (19%)
		PDZ_signaling	620..707	CDD:238492	26/88 (30%)
		DegQ	<702..771	CDD:223343	24/103 (23%)
		PDZ_signaling	722..790	CDD:238492	23/83 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		40/194 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306
		PDZ	1347..1429	CDD:214570
		dbPDZ_assoc	1427..1499	CDD:293216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
dlg1	NP_001162718.1	L27_1	303..359	CDD:286187	10/55 (18%)
		PDZ	454..540	CDD:214570	27/90 (30%)
		PDZ_signaling	566..655	CDD:238492	25/88 (28%)
		PDZ_signaling	742..820	CDD:238492	20/104 (19%)
		SH3_DLG-like	862..922	CDD:212795	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810