Protein Alignment CAPN13 and sol

DIOPT Version :10

• Sequence 1: NP_653176.2
• Gene: CAPN13 / 92291
• HGNCID: 16663
• Length: 669
• Species: Homo sapiens
• Sequence 2: NP_476738.3
• Gene: sol / 44014
• FlyBaseID: FBgn0003464
• Length: 1594
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 153/687 - (22%)
• Similarity: 257/687 - (37%)
• Gaps: 168/687 - (24%)

Human     5 QEPSVETSIIKFKDQDFTT----LRDHCLSMGRTFKDETFPAADSSI----------GQKLLQEK 55
            ||..:..::.:.::.:..|    :..:|......|.|::||.|..|:          |..::|
  Fly   981 QESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQ-- 1043

Human    56 RLSNVIWKRPQDL--PGG--PPHFILDDISRFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQ 116
                  |:||.::  .||  ||..:.......||.||...:||.|:||..|.:.....:::|:.:
  Fly  1044 ------WRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTK 1102

Human   117 SFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYS 181
            ....|  |.::.|..:.|:|..|::||.||.. .:...|..:.:.::.|..|:|||.||:.|.|.
  Fly  1103 EICGQ--GAYQVRLCKDGKWTTVLVDDLLPCD-KRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYE 1164

Human   182 DLHYGFLEDALVDLTGGVITNIHLHSSPV----------DLVKAVKTATKAGSLI---TCATPSG 233
            .|..|...:.|..|||....:|.|.:|.:          ||:.|...:::....:   :|...:.
  Fly  1165 ALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNM 1229

Human   234 PTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCD 298
            ..|..:..:.||...|||:|...:.||..|    ::.|.||  ||...|||.|||.|..|  |.|
  Fly  1230 KVDEEEYQQKGLRPRHAYSVLDVKDIQGHR----LLKLRNP--WGHYSWRGDWSDDSSLW--TDD 1286

Human   299 PRKSQLHKKREDGEFWMSCQDFQQKFIAMFICSEIPITLDHGNTLHEGWSQIMFRKQVILGNTAG 363
            .|.:.:.....:|.||:|.:|....|..:.||.           :..||:::.
  Fly  1287 LRDALMPHGASEGVFWISFEDVLNYFDCIDICK-----------VRSGWNEVR------------ 1328

Human   364 GPRNDAQFNFSVQEPMEGTNVVVCVTVAVTPSNLKAEDAKFPLDFQVILAGSQRFREKFPPVFFS 428
                           ::||...:|....|..:.|:..:|:|.|                   |..
  Fly  1329 ---------------LQGTLQPLCSISCVLLTVLEPTEAEFTL-------------------FQE 1359

Human   429 SFRNTVQSSNNKFRRNFTMTYHLSPGNYVVVAQTRRKSAEFLLRI----------FL---KMPDS 480
            ..||:.:|..::.            ...||:.:||..:|..:.|:          |:   ||.:.
  Fly  1360 GQRNSEKSQRSQL------------DLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKMLER 1412

Human   481 DRHL--SSHFNLRMKGSPSEHGSQQSIFNRYAQQRLDIDATQLQGLLNQELLTGPPGDMFSLDEC 543
            |.:|  ...||....|....|...|.|...::.:||.::...             |......|..
  Fly  1413 DIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQIS-------------PSPHLLADAI 1464

Human   544 RSLVALMELKVNGRLDQEEF--ARLWKRLV---------HYQHVFQKVQTSPGVLLSSDLWKAIE 597
            .||......:..||.....:  .:.|..||         .:.||....|.|..|:.:....|.::
  Fly  1465 ISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVSTRGELKTVD 1529

Human   598 NTDFL-RGIFI---------SRELLHLVTLRYSDSVG 624
            :...| |.:.|         ...:.|.:|.|.::|.|
  Fly  1530 SVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRG 1566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN13	NP_653176.2	Peptidase_C2	35..331	CDD:459889	92/322 (29%)
		Calpain_III	347..474	CDD:469636	19/136 (14%)
		EFh_PEF_CAPN13_14	501..669	CDD:320070	27/145 (19%)
		EF-hand motif	501..529	CDD:320070	4/27 (15%)
		EF-hand motif	542..571	CDD:320070	5/30 (17%)
		EF-hand motif	572..605	CDD:320070	8/33 (24%)
		EF-hand motif	611..639	CDD:320070	5/14 (36%)
		EF-hand motif	641..669	CDD:320070
sol	NP_476738.3	zf-RanBP	6..34	CDD:395516
		RanBP2-type Zn finger	10..29	CDD:275376
		zf-RanBP	135..164	CDD:395516
		zf-RanBP	643..672	CDD:395516
		RanBP2-type Zn finger	647..667	CDD:275375
		zf-RanBP	704..731	CDD:395516
		RanBP2-type Zn finger	708..727	CDD:275376
		zf-RanBP	747..774	CDD:395516
		RanBP2-type Zn finger	749..768	CDD:275376
		zf-RanBP	927..954	CDD:395516
		CysPc	1001..1328	CDD:128526	96/356 (27%)