DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAGI1 and HUL4

DIOPT Version :9

Sequence 1:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	183	Identity:	41/183 - (22%)
Similarity:	68/183 - (37%)	Gaps:	43/183 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   222 TKSYNDMQNAGIVHAENEEED----DVPEMNSSFTADSGEQEEHTLQ-----ETALPPVNSSIIA 277
            |||..:..|...::.:.....    |.|    :|....|:..:..|.     ...|...||:|:
Yeast   573 TKSLFNPMNGLFIYIKESSRSWFAIDPP----NFDKSKGKNSQLELYYLFGVVMGLAIFNSTIL- 632

Human   278 APITDPSQKFPQYL-------PLSAEDNLGPLPENWE-----MAYTENG--EVYFIDHNT--KTT 326
                  ..:||:.|       |||.||.....||...     :.|||:.  :|:.:...|  :..
Yeast   633 ------DLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNN 691

Human   327 SW-LDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGW-----EKIEDPVY 373
            :| |:....:|:...:|.||:...|...: .::.|....|     ||..:|.|
Yeast   692 NWILNDSKSSKEYVTVELCENGRNVPITQ-SNKHEFVMKWVEFYLEKSIEPQY 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	16/86 (19%)
		WW	303..332	CDD:238122	9/38 (24%)
		WW	361..390	CDD:278809	5/18 (28%)
		PDZ	469..555	CDD:214570
		PDZ	640..723	CDD:214570
		MAGI_u5	722..805	CDD:293271
		PDZ_signaling	819..894	CDD:238492
		PDZ_signaling	968..1062	CDD:238492
		PDZ	1123..1205	CDD:214570
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	41/183 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900