DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAGI1 and pub3

DIOPT Version :9

Sequence 1:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens
Sequence 2:	NP_595793.1	Gene:	pub3 / 2539956	PomBaseID:	SPBC16E9.11c	Length:	786	Species:	Schizosaccharomyces pombe

Alignment Length:	345	Identity:	83/345 - (24%)
Similarity:	140/345 - (40%)	Gaps:	65/345 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    97 VTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNF 161
            |:|: :|:.|....:....|.:..:|.|..:   .::..||.....|...|:      |..:::.
pombe    89 VSFR-MREVGSFRSNREVSLTRPLKKSSTTN---LSVLGNLVLKVAPSKIRA------PAGNHSS 143

Human   162 LTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVIT-------TDALHSLQSG------ 213
            .|.........:.|.....|       ||:|.:...:....|       |.|..|..:|
pombe   144 TTANRTTSTPTTTTARTTRT-------TPRPTATTNTSNQSTSNSTRNGTSAATSNGTGTGAGTG 201

Human   214 -SKQSTP---KRTKSYNDMQNAGIVHAENEEEDDVPEMNSSF--TADS-GEQ---EEHTLQETAL 268
             |.:|:|   ::|.:.:.:.|:. .|..:..||....:...:  .||| |..   :.:|...|..
pombe   202 ASHRSSPVTNRQTNNTSALSNSN-AHIMSSFEDQYGRLPPGWERRADSLGRTYYVDHNTRTTTWT 265

Human   269 PPVNSSIIAAPITDPSQKF---PQYLP------LSAEDNLGPLPENWEMAYTENGEVYFIDHNTK 324
            .|.:|:......:..||:.   .::||      |...|:...||..|||.||:.|..||:||||:
pombe   266 RPASSTNPVHNTSSDSQRLNHQNRHLPDDSNPSLMQSDSGNDLPFGWEMRYTDTGRPYFVDHNTR 330

Human   325 TTSWLDPRCLNKQQKPLEECEDDEGVHT-------EELDSELELPAGWEKIEDPVYGIYYVDHIN 382
            ||:|:|||  |...:|      :.|..|       :.|.....||:|||........:|:|||..
pombe   331 TTTWVDPR--NPLVRP------NGGSSTVGSLMQPQSLSHLGPLPSGWEMRLTNSARVYFVDHNT 387

Human   383 RKTQYENPVLEAKRKKQLEQ 402
            :.|.:::|.|.:...:.:.|
pombe   388 KTTTWDDPRLPSALDQDVPQ 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492	1/2 (50%)
		GuKc	122..293	CDD:214504	38/202 (19%)
		WW	303..332	CDD:238122	17/28 (61%)
		WW	361..390	CDD:278809	10/28 (36%)
		PDZ	469..555	CDD:214570
		PDZ	640..723	CDD:214570
		MAGI_u5	722..805	CDD:293271
		PDZ_signaling	819..894	CDD:238492
		PDZ_signaling	968..1062	CDD:238492
		PDZ	1123..1205	CDD:214570
pub3	NP_595793.1	HUL4	4..786	CDD:227354	83/345 (24%)
		C2_Smurf-like	7..130	CDD:176028	9/44 (20%)
		WW	238..267	CDD:278809	6/28 (21%)
		WW	308..337	CDD:278809	17/28 (61%)
		WW	365..397	CDD:197736	11/31 (35%)
		HECTc	434..784	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	57	1.000	Domainoid score	I3528
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900