DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAGI1 and magi1

DIOPT Version :9

Sequence 1:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens
Sequence 2:	XP_031757087.1	Gene:	magi1 / 100379993	XenbaseID:	XB-GENE-940612	Length:	1468	Species:	Xenopus tropicalis

Alignment Length:	1500	Identity:	1166/1500 - (77%)
Similarity:	1266/1500 - (84%)	Gaps:	70/1500 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPR- 63
            |:|||||||||:||||.|.|. .|..||.|:.||||||.|||.|:|           |..||.|
Frog     1 MAKVIQKKNHWSSRVHRCAVSCVGEPGEPGLPVLGGAEDGEFLYLG-----------GAAEGLRC 54

Human    64 ----LGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGS 124
                |.||||||||.||.||||||||||.::.:.|:.|...|||||.||||||||:|||||||.|
Frog    55 SDGELAEGELLLEVAGVPVSGLPRYDVLELVRNSKQPVPITAVRQGSRLNKDLRHYLNQRFQKAS 119

Human   125 PDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGT 189
            |||||||.|||||||||||||||||||||||||||.||||:|||:||:|||||||||||||||||
Frog   120 PDHELQQIIRDNLYRHAVPCTTRSPREGEVPGVDYKFLTVQEFLELEKSGTLLEVGTYEGNYYGT 184

Human   190 PKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE-EDDVPEMNSSFTA 253
            |||||||.|||||:.|||.:..:||||||||||||||||||||:||.::.| :||.|||:||||.
Frog   185 PKPPSQPTSGKVISRDALQNPLAGSKQSTPKRTKSYNDMQNAGVVHTDHYEFDDDAPEMSSSFTG 249

Human   254 DSGEQEEHT--LQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEV 316
            ||.|.:|||  |.:..:||....:...|||:.||..|.||| ..|::|||||:|||||:||||||
Frog   250 DSSEADEHTINLSQDKVPPAARILPTFPITEASQNLPHYLP-PDEESLGPLPDNWEMAFTENGEV 313

Human   317 YFIDHNTKTTSWLDPRCLNKQQKPLEECEDD-EGVHTEELDSEL-----ELPAGWEKIEDPVYGI 375
            ||||||||||||||||||||||||||||||| ||||||||||||     |||||||||||||||:
Frog   314 YFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEEGVHTEELDSELGIGSPELPAGWEKIEDPVYGV 378

Human   376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP--VIP 438
            |||||||:|||||||||||||||||                 .|||:||||.||..:.||  ::|
Frog   379 YYVDHINKKTQYENPVLEAKRKKQL-----------------GQQQSEEWTGDHPTIAPPPIMLP 426

Human   439 NH-PPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLV 502
            |: .|...|||||.....|||||||||||||||||||||||||||||||||||||||||||||||
Frog   427 NNLTPKKKEPARETASHVKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLV 491

Human   503 LDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNT 567
            :|||||||||||||||||||||.||||:|||||||||||||||.|||||||||||||||||||||
Frog   492 VDGPAALDGKMETGDVIVSVNDICVLGYTHAQVVKIFQSIPIGESVDLELCRGYPLPFDPDDPNT 556

Human   568 SLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLA 632
            |||||||||||:||||||||.||||:|:||||.|.|.:||.|||||||::||.||||||||||||
Frog   557 SLVTSVAILDKDPIIVNGQENYDSPSSNSSKTRKANNVKDPRPSSPADISSNGSHGYPNDTVSLA 621

Human   633 SSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQAL 697
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Frog   622 SSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQNL 686

Human   698 THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSH 762
            |||||||:|:||||||||||||||||||||||||||||||||||||||||||||..|.|||||.|
Frog   687 THNQVVDLLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSQHSGHTASPHH 751

Human   763 STQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRI 827
            :...||::|.:||.|.||.|:|||||||||||||||||||||||||:||.|||||||||||||||
Frog   752 AAPGLPDYPTSEAPAVDQADNSGQKKPDPFKIWAQSRSMYENRLPDFQEHDIFLWRKETGFGFRI 816

Human   828 LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLT 892
            ||||||||||:||||||||:||.||||||||||||||||.|:|||||||||||||||||||||||
Frog   817 LGGNEPGEPIFIGHIVPLGSADADGRLRSGDELICVDGTAVVGKSHQLVVQLMQQAAKQGHVNLT 881

Human   893 VRRKVVFAVPKTENEVP-SPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGG 956
            :|||.::.|||.|||.| |||||||||.|||||||||||||||||||||||||||||||||||||
Frog   882 IRRKTIYPVPKAENEAPASPASSHHSSTQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGG 946

Human   957 GGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTF-GNACVAMPHKIGRIIEGSPADR 1020
            ||||.||||||||||||||||||||||||||||||||||||| ||||||||||||||||||||||
Frog   947 GGSGNVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADR 1011

Human  1021 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTT 1085
            ||||||||||||||||||||||||||||||||||||||||||||||:|||:||||||||||||||
Frog  1012 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDETSNASLLTNAEKIATITTT 1076

Human  1086 HTPSQQGTQETRNTTKPKQESQFEFKAPQATQ-EQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1149
            ||| |...|||:|..|||.|.|||||...||| :|:.|:|||:||.|||||||||||||||||||
Frog  1077 HTP-QTIPQETKNNAKPKPEPQFEFKNSPATQPDQEIYSVELDRGLKGFGFSLRGGREYNMDLYV 1140

Human  1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPS 1214
            |||||||||.||||||:|||||||||||||||||:|||||||||||||||.|||||||||||:|.
Frog  1141 LRLAEDGPAARCGKMRVGDEILEINGETTKNMKHARAIELIKNGGRRVRLCLKRGDGSVPEYEPG 1205

Human  1215 SDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEH 1279
            .|.:.|.|.||.|.::.:.|..|.|.|||.:||.|||||..||:|||:.:||||:|||.|..|||
Frog  1206 VDGNSPTTSPQSVSKMNSLPSDRNHSSLEFNYPSDLHKSLQHGDKRAYVKDPKGNREYGRPHNEH 1270

Human  1280 HTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHE 1344
            |||||:| |..|.....|||:|||||..||:| ...||.||:|||||.||||||:||||||||:|
Frog  1271 HTWNGSS-KNYSVQNNRKDRSPEGRRPRQADR-TMTNGQKRQSPEKRNEGTRSAENTLERREKNE 1333

Human  1345 KRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPE-RRAKSTDRRRARSPE 1408
            :|::|||::.|||||.|||||||:|||:||:|.::|||||:|||..||: ||||||||||.||||
Frog  1334 RRKEVSPQKPRERSPVRRRDGSPTRRRKSLDRFMDQRRSPDRRRESSPDRRRAKSTDRRRERSPE 1398

Human  1409 RRRE----------------RSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECS 1457
            ||||                ||.||||:|.|.|:|:|:|.:||.|..||.||..|||||.|||||
Frog  1399 RRRERSPERRREKSTERRRDRSPDKRNKEQRTSNRDRDEHSLKYDTLRSGRHQQEQRRRQYKECS 1463

Human  1458 TDLSI 1462
            |||||
Frog  1464 TDLSI 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492	46/90 (51%)
		GuKc	122..293	CDD:214504	126/173 (73%)
		WW	303..332	CDD:238122	26/28 (93%)
		WW	361..390	CDD:278809	26/28 (93%)
		PDZ	469..555	CDD:214570	81/85 (95%)
		PDZ	640..723	CDD:214570	79/82 (96%)
		MAGI_u5	722..805	CDD:293271	66/82 (80%)
		PDZ_signaling	819..894	CDD:238492	69/74 (93%)
		PDZ_signaling	968..1062	CDD:238492	93/94 (99%)
		PDZ	1123..1205	CDD:214570	74/81 (91%)
magi1	XP_031757087.1	NK	117..>232	CDD:418433	99/114 (87%)
		MAGI_u1	197..257	CDD:406950	39/59 (66%)
		WW	299..328	CDD:395320	26/28 (93%)
		WW	364..395	CDD:197736	28/30 (93%)
		PDZ	458..544	CDD:214570	81/85 (95%)
		PDZ	629..712	CDD:214570	79/82 (96%)
		MAGI_u5	713..800	CDD:406953	69/86 (80%)
		PDZ_signaling	800..883	CDD:238492	76/82 (93%)
		PDZ_signaling	958..1053	CDD:238492	93/94 (99%)
		PDZ	1111..1196	CDD:214570	75/84 (89%)
		PTZ00121	<1221..>1446	CDD:173412	137/226 (61%)
		U2AF_lg	1327..>1433	CDD:273727	65/105 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I7937
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2269	1.000	Inparanoid score	I496
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm54624
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060