DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VAPA and vapal

DIOPT Version :9

Sequence 1:	NP_003565.4	Gene:	VAPA / 9218	HGNCID:	12648	Length:	294	Species:	Homo sapiens
Sequence 2:	NP_001002546.1	Gene:	vapal / 436819	ZFINID:	ZDB-GENE-040718-281	Length:	246	Species:	Danio rerio

Alignment Length:	291	Identity:	178/291 - (61%)
Similarity:	211/291 - (72%)	Gaps:	49/291 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     8 MAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGS 72
            |:|.|||||||||.|||||||||||||.||||:|||:|||||||||||||||||||||||||||:
Zfish     1 MSKLEQILVLDPPNDLKFKGPFTDVVTANLKLKNPSERKVCFKVKTTAPRRYCVRPNSGIIDPGA 65

Human    73 TVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNEND 137
            |:|:||||||||||||||||||||||||||||..||.||:||:||||||||||||||||:|:|||
Zfish    66 TLTISVMLQPFDYDPNEKSKHKFMVQTIFAPPAVSDTEAMWKDAKPDELMDSKLRCVFELPSEND 130

Human   138 KLGITPPGNAPTVTSMSSINNTVATPASYHTKDDPRGLSVLKQEKQKNDMEPSKAVP-LNASKQD 201
            |:                                             |:::.:..|| ||:||.|
Zfish   131 KV---------------------------------------------NEVDSACKVPVLNSSKAD 150

Human   202 GPMP-KPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKV-AHSDKPGSTSTAS 264
            |.:. ||.|.:.:|:|.|:::|:.||||.|:.||.:|||.|:|||||||:: ..:|...|.|:.|
Zfish   151 GLLSVKPLSGAHDDSEMRRILEDRKRLQTELSKLHDENRQLKDEGLRLRRLQPRTDHVSSNSSTS 215

Human   265 F-RDNVTSPLPSLLVVIAAIFIGFFLGKFIL 294
            . ||:|:..||||||||||||||||||||||
Zfish   216 VGRDSVSGSLPSLLVVIAAIFIGFFLGKFIL 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VAPA	NP_003565.4	Motile_Sperm	14..118	CDD:395510	91/103 (88%)
vapal	NP_001002546.1	Motile_Sperm	7..111	CDD:279029	91/103 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341284
Domainoid	1	1.000	196	1.000	Domainoid score	I13190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37824
Inparanoid	1	1.050	353	1.000	Inparanoid score	I8648
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40339
OrthoDB	1	1.010	-	-		D1332028at2759
OrthoFinder	1	1.000	-	-		FOG0000705
OrthoInspector	1	1.000	-	-		oto43660
orthoMCL	1	0.900	-	-		OOG6_101143
Panther	1	1.100	-	-	LDO	PTHR10809
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410