Protein Alignment VAPB and Vap33

DIOPT Version :10

• Sequence 1: NP_004729.1
• Gene: VAPB / 9217
• HGNCID: 12649
• Length: 243
• Species: Homo sapiens
• Sequence 2: NP_570087.1
• Gene: Vap33 / 31349
• FlyBaseID: FBgn0029687
• Length: 269
• Species: Drosophila melanogaster
• Alignment Length: 264
• Identity: 97/264 - (36%)
• Similarity: 142/264 - (53%)
• Gaps: 32/264 - (12%)

Human     8 LSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVM 72
            |::||:|||:|.||||..|.|.:.|.|.:...:.||:|||||:|||||||.|.|....|..|.:.
  Fly    10 LTIEPEHELRFVGPFTRPVVTIMTLRNNSALPLVFKIKTTAPKRYCVRPNIGKIIPFRSTQVEIC 74

Human    73 LQPFDYDPNEKSKHKFMVQSMFAP--TDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDV 135
            ||||.||..||:||||||||:.||  .|.||:..:||:.:||.|||:||:||||:|.......:.
  Fly    75 LQPFVYDQQEKNKHKFMVQSVLAPMDADLSDLNKLWKDLEPEQLMDAKLKCVFEMPTAEANAENT 139

Human   136 EINKII-------------STTASKTETPIVSKSLSSSLDDTEVKKVMEECKR---LQGEVQRLR 184
            .....:             :.|:|.:...:.||...||.|..:...::|..:.   |.||::.||
  Fly   140 SGGGAVGGGTGAAGGGSAGANTSSASAEALESKPKLSSEDKFKPSNLLETSESLDLLSGEIKALR 204

Human   185 EENKQFKEEDGLRMRKTV----------QSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIG 239
            |.|.:.:.|: |.::..:          |.|.|   .||...|:.:....:|:.:...||.:::|
  Fly   205 ECNIELRREN-LHLKDQITRFRSSPAVKQVNEP---YAPVLAEKQIPVFYIAVAIAAAIVSLLLG 265

Human   240 KIAL 243
            |..|
  Fly   266 KFFL 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VAPB	NP_004729.1	Motile_Sperm	8..111	CDD:459882	56/104 (54%)
Vap33	NP_570087.1	Motile_Sperm	9..115	CDD:459882	56/104 (54%)