DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LGI1 and Toll-7

DIOPT Version :9

Sequence 1:	NP_005088.1	Gene:	LGI1 / 9211	HGNCID:	6572	Length:	557	Species:	Homo sapiens
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	49/223 - (21%)
Similarity:	76/223 - (34%)	Gaps:	89/223 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    42 CPAVCTCTKDNALCEN--------ARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLF 98
            ||:.|||..|.....|        ...:||.||.|                        ..::..
  Fly   796 CPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMD------------------------SSVVYL 836

Human    99 TSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163
            ..|:|.|:.:.||||..:|..|::..:.:.:|...||..|.||..|.||:|.|:||....|:.|.
  Fly   837 DGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLS 901

Human   164 S---------------------------------------------------LTNVDLRGNSFNC 177
            :                                                   |.::.|..|.::|
  Fly   902 ALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSC 966

Human   178 DCK-LKWLVEWLGHTNATV----EDIYC 200
            .|: |:.|..::. .||.:    :||||
  Fly   967 RCQFLQALTSYVA-DNALIVQDAQDIYC 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LGI1	NP_005088.1	leucine-rich repeat	71..92	CDD:275378	0/20 (0%)
		LRR_8	91..151	CDD:404697	19/59 (32%)
		LRR 1	92..113		5/20 (25%)
		leucine-rich repeat	93..116	CDD:275378	7/22 (32%)
		LRR 2	116..137		5/20 (25%)
		leucine-rich repeat	117..140	CDD:275378	6/22 (27%)
		LRR 3	140..161		10/20 (50%)
		leucine-rich repeat	141..164	CDD:275378	10/22 (45%)
		PCC	146..>221	CDD:188093	21/111 (19%)
		leucine-rich repeat	165..177	CDD:275378	3/11 (27%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267
		EPTP	225..264	CDD:397689
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313
		EPTP	272..310	CDD:397689
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364
		EPTP	317..361	CDD:397689
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462
		EPTP	420..459	CDD:397689
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506
		EPTP	464..502	CDD:397689
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..549	CDD:397689
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470	11/33 (33%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	7/20 (35%)
		LRR_8	853..913	CDD:290566	17/59 (29%)
		leucine-rich repeat	855..878	CDD:275380	6/22 (27%)
		LRR_4	878..918	CDD:289563	11/39 (28%)
		leucine-rich repeat	879..902	CDD:275380	10/22 (45%)
		leucine-rich repeat	903..926	CDD:275380	0/22 (0%)
		leucine-rich repeat	927..953	CDD:275380	0/25 (0%)
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000