Protein Alignment INTS4 and IntS4

DIOPT Version :10

• Sequence 1: NP_291025.3
• Gene: INTS4 / 92105
• HGNCID: 25048
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_572488.1
• Gene: IntS4 / 31793
• FlyBaseID: FBgn0026679
• Length: 1022
• Species: Drosophila melanogaster
• Alignment Length: 1086
• Identity: 366/1086 - (33%)
• Similarity: 551/1086 - (50%)
• Gaps: 189/1086 - (17%)

Human     1 MAAHLKKRV--YEEFTKVVQPQEEIATKKLRL------TKPSKS-----------AALHIDLCKA 46
            ||..:||||  |.|......|     .|||||      .|..||           |...:|....
  Fly     1 MALAIKKRVGTYVETVDGSPP-----VKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVG 60

Human    47 TSPADAL-------------------------------------QYLLQFARK--------PVEA 66
            ..||.||                                     :.||:...|        .||.
  Fly    61 NLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEM 125

Human    67 ESVEGVVRILLEHYY---KENDPSVRLKIASLLGLLSKTAGFSPDC--------IMDDAINILQN 120
            ..::.|...:.:.|.   :::|.|:|:|:..||      :|...:|        |:|..|.:|:.
  Fly   126 GELKEVASKIFQLYQLQERDSDTSIRVKLLELL------SGLGCECATEQALTMIIDYFIFLLRK 184

Human   121 EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVT 185
            |.|.:||||.:..|..||.:       :..::.::.|  |..:|..:.:       |.|......
  Fly   185 EVSQKVLAQGMMCLFRIGER-------RKHMLPISYK--TQVAHLAKEQ-------LRSGSAHTQ 233

Human   186 KDAEGLAARDVQKIIGD---------YFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLL 241
            |:|..:..|...|:.|:         |...||..||..|:.|:|.|.|||.:|...:|.:|.:.:
  Fly   234 KNAMLVIGRFATKMEGERHYVWKLAFYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAM 298

Human   242 SDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLL 306
            .||||.||..|:||::::...:|:.|:|.....||:|::|.||.|:|..:.|.|..:||.||:||
  Fly   299 KDDYECVRKEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELL 363

Human   307 GSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLI 371
            |.|..||..||.|||||||||:||||||||||...|.:|||:|||::|.||||:|.:|..::::|
  Fly   364 GGMTAVSREFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISII 428

Human   372 ESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMR 436
            .||||||.:||||||..|||.|||.::|.||.|.|.||...|||||||||||||:|||::|:::.
  Fly   429 ASGACGALIHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLT 493

Human   437 KISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRD 501
            .|:.:|.||||||:.:|..|||.|.|:||.||.:|....|||:..:.:.:.:||..|.|||.||:
  Fly   494 AIAKHIVLREDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRN 558

Human   502 SIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPALFS 566
            |.:.|::.:|.:||.||:.:...||..||||:|.|.|::||||:.||:|:||||:....:.:|..
  Fly   559 STYACMRKIGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLP 623

Human   567 DHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS----PSIIPQEDPSQQFLQQSLERVYSLQHL 627
            ..|.|||||||||:.:|||.|.:.|   .|||.:    .|.:.|...|.::||..|..:..:..:
  Fly   624 TATHRHYAYLRDSMPNLVPQLPIEG---ASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTM 685

Human   628 DPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDL 692
            ..: ..|||:....:|||||.:.:.:.|.::|..|:|..| :.|:.:|.......:.:.||:| |
  Fly   686 TDE-RLELLQTAQSNLQRLGSIDAGMYGTSNFLETFLAAQ-IQIEQMQRCASTQRSRVPLKES-L 747

Human   693 ASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQE 757
            |:     ::....|::..:||:....::.:..:||:|.||.|::..| .|....| |.|:..||.
  Fly   748 AA-----LIRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVR-DRSQSAL-GPCQMLLQT 805

Human   758 VDFFQRYFIA--------------DLPHLQ--------DSFVDKLLDLMPRLMTSKPAEVVKILQ 800
            ......:..|              |:|..:        |||..:||..:..:...||..|.:.:.
  Fly   806 AGDISEFIKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREIL 870

Human   801 TMLRQSAFLHL-PLPEQIHKASATIIEPA--GESDNPLRFTSGLVVALDVDATLEHVQDPQNT-V 861
            .:::|:..|.| |..::|.:..|.|:||.  ...||.::.|:||:.|:...|.::::.:.|.. :
  Fly   871 PLVQQAPPLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADM 935

Human   862 KVQVLYPDGQAQMIHPKPADFRNPGP-----GRH----RLITQVYLSHTAWTEACQVEVRLLLAY 917
            ::::.|||.....:.||.:||:   |     |.|    ||.|.:.|||:.|||:..||::|.||.
  Fly   936 RIKIKYPDQHMHTVVPKQSDFK---PIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLAV 997

Human   918 NSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKPARR 963
            ...:.:..|                       ||.||...|||.||
  Fly   998 RPGSELELC-----------------------KPAKVLFAPKPVRR 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS4	NP_291025.3	HEAT	65..222	CDD:441023	42/176 (24%)
		HEAT 1	66..105		8/41 (20%)
		HEAT repeat	115..143	CDD:293787	11/27 (41%)
		HEAT 2	145..183		5/37 (14%)
		HEAT repeat	155..182	CDD:293787	5/26 (19%)
		HEAT	157..309	CDD:441023	54/160 (34%)
		HEAT 3	190..228		15/46 (33%)
		HEAT repeat	199..221	CDD:293787	8/30 (27%)
		HEAT 4	229..263		12/33 (36%)
		HEAT repeat	233..272	CDD:293787	14/38 (37%)
		HEAT 5	277..313		16/35 (46%)
		HEAT repeat	282..311	CDD:293787	14/28 (50%)
		HEAT repeat	320..347	CDD:293787	20/26 (77%)
		HEAT repeat	360..398	CDD:293787	21/37 (57%)
		HEAT 6	369..405		22/35 (63%)
		HEAT	<375..466	CDD:441023	55/90 (61%)
		HEAT 7	406..444		22/37 (59%)
		HEAT repeat	411..441	CDD:293787	18/29 (62%)
		HEAT 8	446..484		18/37 (49%)
		HEAT repeat	447..475	CDD:293787	14/27 (52%)
		HEAT repeat	486..512	CDD:293787	10/25 (40%)
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	13/35 (37%)
		HEAT repeat	339..414	CDD:293787	45/74 (61%)
		HEAT	<432..530	CDD:441023	59/97 (61%)
		HEAT repeat	432..459	CDD:293787	17/26 (65%)
		HEAT repeat	468..498	CDD:293787	18/29 (62%)
		HEAT repeat	504..528	CDD:293787	13/23 (57%)