DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCLK1 and lok

DIOPT Version :9

Sequence 1:	NP_001317000.1	Gene:	DCLK1 / 9201	HGNCID:	2700	Length:	740	Species:	Homo sapiens
Sequence 2:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster

Alignment Length:	286	Identity:	106/286 - (37%)
Similarity:	158/286 - (55%)	Gaps:	18/286 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   378 EGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKE--------HMIQ 434
            |...:|..|.:.|.|.|.:|.|.:.:|:...:..|.:::|:||:||:...|..        ..:.
  Fly   162 ESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL 226

Human   435 NEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGM-LYNLASA 498
            ||..|::.:.||.:|.:.:.:|.|..:|:|:|.::||||.:.|.| ||....|.|.: .|.:..|
  Fly   227 NEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIIS-NKLLSEDISKLYFYQMCHA 290

Human   499 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAE 561
            :||||...|.|||:||:|:|: |..|....||:.||||:..|  |..:.|:||||.|||||::..
  Fly   291 VKYLHDRGITHRDLKPDNVLL-ETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLIT 354

Human   562 TG---YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 623
            .|   |..|||||:.||:.:..|.|..||  |.:.......||..|:..:..|.|.:||..||.|
  Fly   355 GGREAYTKKVDIWSLGVVLFTCLSGTLPF--SDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLL 417

Human   624 ITMMLLVDVDQRFSAVQVLEHPWVND 649
            |..||:||.::|.|...||:..|:.|
  Fly   418 INQMLIVDPERRPSIDDVLQSSWLRD 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..378		106/286 (37%)
		STKc_DCKL1	383..650	CDD:271085	105/281 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..740
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	103/277 (37%)
		S_TKc	174..441	CDD:214567	101/270 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910