DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACVR2A and acvr2aa

DIOPT Version :9

Sequence 1:	NP_001265508.1	Gene:	ACVR2A / 92	HGNCID:	173	Length:	513	Species:	Homo sapiens
Sequence 2:	XP_021334336.1	Gene:	acvr2aa / 553359	ZFINID:	ZDB-GENE-980526-227	Length:	538	Species:	Danio rerio

Alignment Length:	538	Identity:	410/538 - (76%)
Similarity:	470/538 - (87%)	Gaps:	25/538 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWE-KDRTNQTGVEPCYGDKDKRRHCFATW 64
            ||.|.||||.||||||||||||||||||||:|:|.|.. ::|.|::|:|||.||||||.||||||
Zfish     1 MGPATKLAFGVFLISCSSGAILGRSETQECVFYNYNPSLENRGNRSGIEPCVGDKDKRLHCFATW 65

Human    65 KNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFP----------- 118
            :|:||::|||||||||||:||||.|:|||||:.|:|:|||||||||||||.|.|
Zfish    66 RNVSGTVEIVKQGCWLDDVNCYDSTECVEKKEDPDVFFCCCEGNMCNEKFFYNPNTAPVQSKAPF 130

Human   119 -----EMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQ-- 176
                 :.:|.:.||||:|.|||.::.||||:||:|.||.||:.:||:|||||:||||||||||
Zfish   131 SDTKSDTKVFKATSNPLTQKPPLFSTLLYSIVPIMGIAAIVLLSFWMYRHHKLAYPPVLVPTQHA 195

Human   177 ------DPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEV 235
                  ||||.||||.|..|||||||:||||||||||||||||:||||||||||||.||||||::
Zfish   196 FHIMIEDPGPMPPSPTLVQKPLQLLEIKARGRFGCVWKAQLLNDYVAVKIFPIQDKLSWQNEYDI 260

Human   236 YSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 300
            |::|||:||||||||||||||:::|::||||||:|||.||:|:||||||:||||||||:||||||
Zfish   261 YNIPGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMARGL 325

Human   301 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 365
            ||||.|.||.:|||||||:|||.||||||||.|||||||||||||||||||||||||||||||||
Zfish   326 AYLHSDFPGHRDGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 390

Human   366 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQE 430
            ||||||||||||||||||||||||:||||||||:||||:||||||||||||||:||||:||||||
Zfish   391 MAPEVLEGAINFQRDAFLRIDMYAVGLVLWELAARCTASDGPVDEYMLPFEEEVGQHPTLEDMQE 455

Human   431 VVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIV 495
            ||||||.||.||:.||||.|:|||||||||||||:||||||||||.||:.||||.|::...|:||
Zfish   456 VVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEERVVQMQRQTSVSAPEEIV 520

Human   496 TVVTMVTNVDFPPKESSL 513
            ||||||||||:|||||||
Zfish   521 TVVTMVTNVDYPPKESSL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2A	NP_001265508.1	Activin_recp	38..114	CDD:395845	55/76 (72%)
ACVR2A	NP_001265508.1	STKc_ACVR2a	196..485	CDD:271043	247/288 (86%)
acvr2aa	XP_021334336.1	Activin_recp	43..115	CDD:307282	54/71 (76%)
acvr2aa	XP_021334336.1	STKc_ACVR2a	221..510	CDD:271043	247/288 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326400
Domainoid	1	1.000	138	1.000	Domainoid score	I19589
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20391
Inparanoid	1	1.050	873	1.000	Inparanoid score	I2997
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D149209at7742
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		oto44293
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270