Protein Alignment ACVR2A and Acvr2a

DIOPT Version :9

• Sequence 1: NP_001265508.1
• Gene: ACVR2A / 92
• HGNCID: 173
• Length: 513
• Species: Homo sapiens
• Sequence 2: XP_006497686.1
• Gene: Acvr2a / 11480
• MGIID: 102806
• Length: 521
• Species: Mus musculus
• Alignment Length: 521
• Identity: 511/521 - (98%)
• Similarity: 513/521 - (98%)
• Gaps: 8/521 - (1%)

Human     1 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWK 65
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse     1 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWK 65

Human    66 NISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPV 130
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse    66 NISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPV 130

Human   131 TPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQ--------DPGPPPPSPLL 187
            ||||||||||||||||||||||||||||||||||||||||||||||        |||||||||||
Mouse   131 TPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQHAFHIMIEDPGPPPPSPLL 195

Human   188 GLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGA 252
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 GLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGA 260

Human   253 EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA 317
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA 325

Human   318 ISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAF 382
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 ISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAF 390

Human   383 LRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQK 447
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 LRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQK 455

Human   448 HAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESS 512
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 HAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESS 520

Human   513 L 513
            |
Mouse   521 L 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACVR2A	NP_001265508.1	Activin_recp	38..114	CDD:395845	73/75 (97%)
		STKc_ACVR2a	196..485	CDD:271043	288/288 (100%)
Acvr2a	XP_006497686.1	Activin_recp	<59..114	CDD:395845	53/54 (98%)
		STKc_ACVR2a	204..493	CDD:271043	288/288 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83953626
Domainoid	1	1.000	566	1.000	Domainoid score	I5816
eggNOG	1	0.900	-	-		E2759_KOG3653
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20391
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I5254
Isobase	1	0.950	-	0	Normalized mean entropy	S3305
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		oto116631
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.220