Protein Alignment KCNAB3 and Hk

DIOPT Version :10

• Sequence 1: XP_047293000.1
• Gene: KCNAB3 / 9196
• HGNCID: 6230
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Alignment Length: 302
• Identity: 142/302 - (47%)
• Similarity: 200/302 - (66%)
• Gaps: 22/302 - (7%)

Human    64 PAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTA 128
            ||..||..:....|::|:||||||||:|.:|||||..|...:||:.||.:|.:|.|.|:||||.:
  Fly   189 PALPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDIS 253

Human   129 EVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYV 193
            |.:    :|..:|.||:..||:|::||||||::|..::| |||||||||||.:|.||:||||.|:
  Fly   254 EAH----SETEIGKILQRAGWKRTAYVITTKVYWSTKSE-ERGLSRKHIIECVRASLQRLQLQYI 313

Human   194 DIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEH 258
            |||..:::||.||| |:||||:|||.||.|:||||:||...||||||:..||||.|.|:.||:|:
  Fly   314 DIVIIHKADPMCPM-EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEY 377

Human   259 HLFQREKVEMQLPELYHKIGVGSVTWYPLACGLI-TSKYDGRVPDTCRASIKGYQWLKDKV---- 318
            |:|.|||.|:.|||:|:|||||.:.|.||:..|. |...|...........|.:.|.:|::
  Fly   378 HMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEINRNA 442

Human   319 -----------QSEDGKKQQAKVMDLLPVAHQLGCTVAQLAI 349
                       :.::|::...::.||..:|.:|||:..||:|
  Fly   443 ALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSI 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNAB3	XP_047293000.1	AKR_SF	76..349	CDD:444925	137/288 (48%)
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	137/288 (48%)