DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COG7 and cog7

DIOPT Version :9

Sequence 1:	NP_705831.1	Gene:	COG7 / 91949	HGNCID:	18622	Length:	770	Species:	Homo sapiens
Sequence 2:	NP_001070861.1	Gene:	cog7 / 768247	ZFINID:	ZDB-GENE-061013-463	Length:	767	Species:	Danio rerio

Alignment Length:	770	Identity:	543/770 - (70%)
Similarity:	652/770 - (84%)	Gaps:	3/770 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQEVNHAVEETSHQALQN 65
            ||||||||||||||:|:|.||:...|: |.||||.||:||||||||||||||:::||:|:|||||
Zfish     1 MDFSKFLADDFDVKDWVNGAFKVAQKD-APGKADAHASTLVMKLQLFIQEVNNSIEESSNQALQN 64

Human    66 MPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADK 130
            ||:||||:|||||||||||:||||||||||||||||.|||||||||||||||||||||:||||||
Zfish    65 MPRVLRDIEALKQEASFLKDQMILVKEDIKKFEQDTVQSMQVLVEIDQVKSRMQLAAEALQEADK 129

Human   131 WSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAA 195
            ||||||||||||||||:||||:|||.||.||.|||||||||||||.|||||||||||.|.|||:.
Zfish   130 WSTLSADIEETFKTQDVAVISSKLTAMQGSLAMLVDTPDYSEKCVQLEALKNRLEALTSTQIVST 194

Human   196 FTSQAVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGA 260
            |.|.|.||:|:||:||||:|||||||||||||||.|||..|:.:||||..|.:||:..||.||..
Zfish   195 FNSLATDQAKLFVRVFTEMDRMPQLLAYYYKCHKAQLLTVWESICQSDAPLKQQLSEFYDTLLST 259

Human   261 WHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFA 325
            ||||:||::|||:.|.||:.||:||||||::||:|.|::..::|...:..|..|||.:..:|:|:
Zfish   260 WHTQLQWSSQVFRNPCEVLTVLMIQTLGAMVPSIPDCIAETLKRCSGDCRLDVLLELHQTSANFS 324

Human   326 KGLEMALLPHLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQE 390
            :.||.|:.|.|.|.||:||.|||..||.|||.||::||.:||:|||||:||||||.|||:|||.|
Zfish   325 RSLEAAMQPQLGECNLLKVAELVSCVYSPYKTYQIQYGGLEETNLLIQLSAVPLERGEVLDCVLE 389

Human   391 LSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLDHIPPN 455
            |:|||.|:||||:|||||||:||:||..|||:.||::||.||||||:.||||||||.||:..|.:
Zfish   390 LTHSVQKVFGLAAAAVDRCVKFTDGLAVCGLIKALRALFNKYVSDFSVTLQSIRKKYKLEDTPTS 454

Human   456 SLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPRSLAGFQESILTD 520
            .:|.|||||||||:|:|||||||||.||.|||||:|:||..||::|.:..:||||.|.||.:.
Zfish   455 EVFTEDWTAFQNSVRVIATCGELLRQCGAFEQQLSNKILGRAGRFLWEGFNPRSLTGLQEGVA-- 517

Human   521 KKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDS 585
            ::.|.|||||||||||:.|.|||.:|:|.|::|||||:.|.:|||..|||||||||||:||||||
Zfish   518 ERRSQKNPWQEYNYLQQSNTAEYNNLLETLHSLKEKGTGNSSLLAETRAALTRLNQQANQLAFDS 582

Human   586 VFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDS 650
            |||:|||||.|::|.::..:|.:||||||:||||||:|.|||:|||||||||||:|||||||||.
Zfish   583 VFLQIKQQLFLLNKPEARGSASLGETLTDDLPAFSLSPQEYITNIGQYIMSLPLHLEPFVTQEDP 647

Human   651 ALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQIPELSPHSAKQLATDI 715
            |||||||.||||:||||||::|||:|.||.|||||||||||||||.|||:||||.|..|||||||
Zfish   648 ALELALHTGKLPYPPEQGDDVPELENTADYWLGSIARATMQTYCDVILQLPELSAHHTKQLATDI 712

Human   716 DYLINVMDALGLQPSRTLQHIVTLLKTRPEDYRQVSKGLPRRLATTVATMRSVNY 770
            |||.|||||||||.|||||:|||||:.:|::|||.:|.|||||:.|:|.:|.:.|
Zfish   713 DYLSNVMDALGLQTSRTLQNIVTLLRVKPDEYRQTAKTLPRRLSATIANIRGLEY 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COG7	NP_705831.1	COG7	2..767	CDD:287200	540/764 (71%)
cog7	NP_001070861.1	COG7	2..764	CDD:287200	540/764 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194336419
Domainoid	1	1.000	1045	1.000	Domainoid score	I371
eggNOG	1	0.900	-	-		E1_KOG4182
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33431
Inparanoid	1	1.050	1051	1.000	Inparanoid score	I2092
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG55378
OrthoDB	1	1.010	-	-		D198192at33208
OrthoFinder	1	1.000	-	-		FOG0007167
OrthoInspector	1	1.000	-	-		oto42685
orthoMCL	1	0.900	-	-		OOG6_104376
Panther	1	1.100	-	-	LDO	PTHR21443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4519
SonicParanoid	1	1.000	-	-		X5277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300