Protein Alignment DDX21 and Prp5

DIOPT Version :10

• Sequence 1: NP_004719.2
• Gene: DDX21 / 9188
• HGNCID: 2744
• Length: 783
• Species: Homo sapiens
• Sequence 2: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Alignment Length: 808
• Identity: 214/808 - (26%)
• Similarity: 346/808 - (42%)
• Gaps: 133/808 - (16%)

Human    18 KKGETLRKQTEEKEKKEKPKSDKTEEIAEEEETVFPKAKQV---------KKKAEPSEVDMNSPK 73
            |.|..|..:.|...|||.|..|..:||.::.|.|..|.:.|         |.|.||.:..:.:..
  Fly   291 KLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKS 355

Human    74 SKKAKKKEEPS------------------------QNDISPKTKS--------LRKKKEPIEKK- 105
            ..:.:.|.:|.                        .|.::|..||        :.|||....||
  Fly   356 EPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKG 420

Human   106 -VVSSKTKKVTKNEEPSEEEI-DAPKPKKMKKEKEM---NGETREKSPKLKNGFPHPEPDCNPSE 165
             |:......:..:.|...|:| |......||..||:   :..:...:|..|| |....|:.....
  Fly   421 EVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKN-FYVEVPELTRMT 484

Human   166 AAS-EESNSEIEQEIPVEQKE-----GAFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGK 224
            ||. |:..|::| .|.|:.|.     ..::...:|::.:::|:..|.....|||.:....:.||:
  Fly   485 AADVEKYRSDLE-GIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGR 548

Human   225 DLIAQARTGTGKTFSFAIPLIEKL--HGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKKL 287
            |||..|:||:|||.:|.:|:...:  ...::|   |.....:::||||||..|:.||....:|.|
  Fly   549 DLIGIAKTGSGKTLAFILPMFRHILDQPSMED---GDGAIAIIMAPTRELCMQIGKDIRKFSKSL 610

Human   288 SV--ACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHI--QNGKL-DLTKLKHVVLDEVDQMLDM 347
            .:  .|.||||....|...::.|.:|:|.||||:.|.:  .:|:: :|.::.:|||||.|:|.||
  Fly   611 GLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDM 675

Human   348 GFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKTAITVE 412
            ||..||..|:.     :...:.||::||||.|..:..:|::.:|...|.:  :|.::.......:
  Fly   676 GFEPQVMRIID-----NVRPDRQTVMFSATFPRQMEALARRILKKPIEVI--VGGRSVVCKEVEQ 733

Human   413 HLAIKCHWTQRAAVIGDVIRVYSGHQGRTIIFCETKKEAQELSQNSAIKQD--AQSLHGDIPQKQ 475
            |:.| .:...:...:.:::.:|. ..|..|:|.: |:|..::.....:|..  ..||||.|.|..
  Fly   734 HVVI-LNDDAKFFKLLELLGIYQ-EAGSIIVFVD-KQENADILLRDLMKASYPCMSLHGGIDQFD 795

Human   476 REITLKGFRNGSFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGVCICF 540
            |:.|:..|::|...:|:||:|||||||:.::.||:....|...|.|:||.|||||||:.|....|
  Fly   796 RDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTF 860

Human   541 YQHKE--------------------EYQLVQVEQKA------------------GIKFKRIGVPS 567
            ...::                    |.|.:..|.||                  |.||......:
  Fly   861 ITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNA 925

Human   568 ATEIIKASSKDAIRLLDSVPPTAISH-FKQSAEKLIEEKGAVE---ALAAALAHISGATSVDQRS 628
            |.| .|...|.|:.|.||.....|.. ..|..|::...|..|:   |.|.|.|..:.|.:....:
  Fly   926 AKE-SKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAA 989

Human   629 LINSNVGFVTMILQ--CSIEMPNISYAWKELKEQLGEEIDSKVKGMVFLKGKLGVCFDVPTASVT 691
            :..:|....:...|  .:....||:.|........| ...|...|......||.:        ..
  Fly   990 VSGANPALASAAAQAAAAAAAANIAIAAASAPAAAG-GAPSVAMGGALSSDKLEL--------AK 1045

Human   692 EIQEKWHDSRRWQL--SVATEQPELEGP 717
            .:..|.:.|:....  ||.|.:|.::||
  Fly  1046 RLASKINSSKNLDTKGSVVTVEPMIKGP 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX21	NP_004719.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..188		52/222 (23%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	186..214		5/27 (19%)
		SrmB	188..574	CDD:440279	128/432 (30%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	339..342		2/2 (100%)
		GUCT_RHII_Gualpha_beta	617..709	CDD:240593	15/95 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..783		4/10 (40%)
		AdoMet_MTases	718..>771	CDD:473071	214/808 (26%)
		3 X 5 AA repeats	724..748
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	21/91 (23%)
		DEAD-like_helicase_N	454..899	CDD:475120	138/459 (30%)
		KH-I_DDX46	1121..1223	CDD:411901