DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX21 and mahe

DIOPT Version :9

Sequence 1:	NP_004719.2	Gene:	DDX21 / 9188	HGNCID:	2744	Length:	783	Species:	Homo sapiens
Sequence 2:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	190/747 - (25%)
Similarity:	312/747 - (41%)	Gaps:	177/747 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    61 KAEPSEVDMNSPKSKKAKKKEEPSQNDISPKTKSLRKKKEPIEKKVVSSKTKKVTKNEEPSEEEI 125
            |.|.:|:        :.:|.:.|.:|.:.||.::|    ||..|...:.....:.|:|:...|
  Fly   168 KEERAEI--------QREKAKNPGRNLVKPKWENL----EPFLKDFYNIHPNTLAKSEQQVAE-- 218

Human   126 DAPKPKKMKKEKEMNGETREKSPKLKNGFPHPEPDCNPSEAASEESNSEIEQEIPVEQKEGAFSN 190
                   :::|.|:.....|        .|||       ..:.|||:
  Fly   219 -------IRRELEITVSGNE--------LPHP-------VVSFEESS------------------ 243

Human   191 FPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLHGELQDR 255
              :....|:.:|.:|.|....||::.:....||:||:..|:||:|||.::.:|.|..: |.....
  Fly   244 --LPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHI-GNQPPI 305

Human   256 KRGRAPQVLVLAPTRELANQVS---KDFSDITK-KLSVACFYGGTPYGGQFERMRNGIDILVGTP 316
            .||..|..||||||||||.|:.   :|:..:.| ::...|.:||:....|...:..|:::::.||
  Fly   306 IRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATP 370

Human   317 GRIKDHIQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHW 381
            ||:.|.::|...:|.:..::||||.|:||||||..|:.:|:     :....:.|.:::|||.|..
  Fly   371 GRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKII-----EQIRPDRQVVMWSATWPKE 430

Human   382 VFNVAKKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQR----AAVIGDVIRV-YSGHQG-R 440
            |..:|..:: :.|.|:: ||.........:..:...|...::    ..::.::..: .||:.| :
  Fly   431 VQALAGDFL-NDYIQIN-IGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNK 493

Human   441 TIIFCETKKEAQELSQ-NSAIKQDAQSLHGDIPQKQREITLKGFRNGSFGVLVATNVAARGLDIP 504
            .|:|.|||.:.:::.| ..|...:|.|:|||..|.:|:..||.||||...:|:||:||:||||:.
  Fly   494 IIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVE 558

Human   505 EVDLVIQSSPPKDVESYIHRSGRTGRAGRTGVCICFY---QHKEEYQLVQVEQKAGIKFKRIGVP 566
            ::..||....|...|:|:||.|||||..:.|....|:   ..|:..:|:.|.::||
  Fly   559 DLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAG--------- 614

Human   567 SATEIIKASSKDAIRLLDSVPPTAISHFKQSAEKLIEEKGAVEALAAALAHISGATSVDQRSLIN 631
                  :..|:..:.|..|:|.                              ||....::|...|
  Fly   615 ------QTPSQALLDLARSMPS------------------------------SGGYRGNKRWNNN 643

Human   632 S----NVGFVTMILQCSIEMPNISYAWKELKEQLGEEIDSKVKGMVFLKGKLGVCFDVPTASVTE 692
            |    |.|....|.|.....|        |..|.|...::...|             .||.|
  Fly   644 SGGDRNTGGNNGIYQQRNNNP--------LNYQAGNNYNNNRSG-------------PPTGS--- 684

Human   693 IQEKWHDSRRWQLSVATEQPELE-GPREGYGGFRGQREGSRGFRG--QRDGN------------- 741
                     .:|...|.....|: |...|....|..:.|..|..|  ||:||
  Fly   685 ---------SYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQQQRNGNTYRPRAPFNNGGP 740

Human   742 RRFRGQREGSRGPRGQRS-GGGNKSNRSQNKG 772
            |...|.:.|..|..|... |||.:...:..:|
  Fly   741 RAIMGHQGGGVGAGGAAGVGGGPQQLMAPQQG 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX21	NP_004719.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..188		24/126 (19%)
		SrmB	178..587	CDD:223587	126/422 (30%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	186..214		5/27 (19%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	339..342		2/2 (100%)
		GUCT_RHII_Gualpha_beta	617..709	CDD:240593	18/95 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..783		21/82 (26%)
		AdoMet_MTases	718..>771	CDD:327401	17/68 (25%)
		3 X 5 AA repeats	724..748		10/38 (26%)
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	158/596 (27%)
		DEADc	239..446	CDD:238167	72/233 (31%)
		HELICc	457..594	CDD:238034	46/136 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820