Protein Alignment BUB3 and CG12782

DIOPT Version :10

• Sequence 1: NP_004716.1
• Gene: BUB3 / 9184
• HGNCID: 1151
• Length: 328
• Species: Homo sapiens
• Sequence 2: NP_611772.2
• Gene: CG12782 / 37685
• FlyBaseID: FBgn0034838
• Length: 336
• Species: Drosophila melanogaster
• Alignment Length: 329
• Identity: 91/329 - (27%)
• Similarity: 146/329 - (44%)
• Gaps: 26/329 - (7%)

Human     2 TGSNEFKLNQPPEDGISSVKFSPNTSQF--LLVSSWDTSVRLYDVPANSMRLKYQHT--GAVLDC 62
            |...:::|..||.|.||:::|||.:|.:  :...|||.:||:::|.|:.:..|..::  |...|.
  Fly    10 TQQQDYELPNPPNDTISALEFSPRSSSWNAICAGSWDNTVRIWEVQADRLVPKVMNSLEGTPFDV 74

Human    63 AFYDP-THAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVN-VMVTGSWDQTVKLWDP 125
            .:.|. ...:......|:...||.::|...||.|   .|....|..|. .:.|.|||::::.|||
  Fly    75 TWNDSGNKVYLSDSSGQVTEWDLESNQLRKVGLH---ARAARTCHWVGPYLATTSWDKSIRFWDP 136

Human   126 RTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESS---LKYQTRCIRA 187
            |..........|::.|...|..|..:|....|.:|.:.||. |.|:|.|..|   ...|.|.:..
  Fly   137 RAAIELTRMELPDRSYAADVLNDVAVVACGDRSILAYTLRG-GPVEQGRMKSPGESNTQVRSVAL 200

Human   188 FPNKQ--GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFA 250
            ..|:.  .::::...|.|    .|.|...:...:..:|||.:.:.|..:|.||.:..:.:....|
  Fly   201 HQNRDLTSWLIAKTNGMV----FDQSMAHRTVSFPIRCHRRENSGILDVYAVNEVKVNMVTQHIA 261

Human   251 TGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE-----MDDTEHPEDG 310
            |.||||....||...:.:|.:...:|..|...|.|.||...|.|..|.:.     .|.:..|.
  Fly   262 TVGSDGVFCFWDSQMRSKLLESKVHPQPITKCAISGDGKLFAYALGYDWSKGHEYSDSSIKPH-- 324

Human   311 IFIR 314
            ||:|
  Fly   325 IFLR 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BUB3	NP_004716.1	WD 1	4..44		15/41 (37%)
		WD40	<11..296	CDD:441893	83/295 (28%)
		WD40 repeat	17..54	CDD:293791	14/38 (37%)
		WD 2	47..84		5/39 (13%)
		WD40 repeat	60..94	CDD:293791	7/34 (21%)
		WD 3	87..125		12/38 (32%)
		WD40 repeat	99..134	CDD:293791	11/35 (31%)
		WD 4	129..164		7/34 (21%)
		WD40 repeat	141..175	CDD:293791	11/33 (33%)
		WD 5	170..210		9/44 (20%)
		WD40 repeat	182..222	CDD:293791	6/41 (15%)
		WD 6	217..263		14/45 (31%)
		WD40 repeat	237..274	CDD:293791	11/36 (31%)
		WD 7	267..316		15/53 (28%)
CG12782	NP_611772.2	WD40	25..303	CDD:475233	78/285 (27%)
		WD40 repeat	26..64	CDD:293791	13/37 (35%)
		WD40 repeat	71..101	CDD:293791	5/29 (17%)
		WD40 repeat	109..146	CDD:293791	11/36 (31%)
		WD40 repeat	195..235	CDD:293791	6/43 (14%)
		WD40 repeat	242..272	CDD:293791	10/29 (34%)