Protein Alignment BUB3 and Rae1

DIOPT Version :10

• Sequence 1: NP_004716.1
• Gene: BUB3 / 9184
• HGNCID: 1151
• Length: 328
• Species: Homo sapiens
• Sequence 2: NP_611597.1
• Gene: Rae1 / 37467
• FlyBaseID: FBgn0034646
• Length: 346
• Species: Drosophila melanogaster
• Alignment Length: 339
• Identity: 124/339 - (36%)
• Similarity: 184/339 - (54%)
• Gaps: 25/339 - (7%)

Human     5 NEFKLNQPPEDGISSVKFSPNTSQ--FLLVSSWDTSVRLYDVPANSMRL-KYQHT--GAVLD-CA 63
            |:|::..||:|.:|:::|||:|.|  ||:..|||::||.::|..|...: |...|  |.||| |.
  Fly    12 NDFEVASPPDDSVSALEFSPSTVQKNFLVAGSWDSTVRCWEVEQNGATVPKSMKTMGGPVLDVCW 76

Human    64 FYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYC--PEVNVMVTGSWDQTVKLWDPR 126
            ..|.:..:....|.|:|:.||.:||...|..||.|::.....  |....::|||||:|:|.||.|
  Fly    77 SDDGSKVFVASCDKQVKLWDLASDQVMQVAAHDGPVKTCHMVKGPTYTCLMTGSWDKTLKFWDTR 141

Human   127 TPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNK 191
            :|....|.:.||:.|...|.....:||||.|.::::.|:|.....:|:||.||||.|.|..|.:|
  Fly   142 SPNPMMTINLPERCYCADVEYPMAVVGTANRGLIIYSLQNSPTEYKRQESPLKYQHRAISIFRDK 206

Human   192 Q----GYVLSSIEGRVAVEYLDP-SPEVQKKKYAFKCHRLK-ENNIEQIYPVNAISFHNIHNTFA 250
            :    |..|.|||||||::|::| :|   |..:.|||||.. .:..:.||.||.|:||.:|.|..
  Fly   207 KKEPTGCALGSIEGRVAIQYVNPGNP---KDNFTFKCHRTTGTSGYQDIYAVNDIAFHPVHGTLV 268

Human   251 TGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYE-----MDDTEHPEDG 310
            |.||||..:.||...:.:|........||....|:.:|...|.|..|.:.     .:..:.|:
  Fly   269 TVGSDGTFSFWDKDARTKLKSSETMDQSITKCGFNANGQIFAYAVGYDWSKGHEYFNPAKKPQ-- 331

Human   311 IFIRQVTDAETKPK 324
            ||:|...| |.||:
  Fly   332 IFLRSCYD-ELKPR 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BUB3	NP_004716.1	WD 1	4..44		18/40 (45%)
		WD40	<11..296	CDD:441893	113/298 (38%)
		WD40 repeat	17..54	CDD:293791	16/39 (41%)
		WD 2	47..84		12/40 (30%)
		WD40 repeat	60..94	CDD:293791	12/34 (35%)
		WD 3	87..125		15/39 (38%)
		WD40 repeat	99..134	CDD:293791	12/36 (33%)
		WD 4	129..164		10/34 (29%)
		WD40 repeat	141..175	CDD:293791	10/33 (30%)
		WD 5	170..210		21/43 (49%)
		WD40 repeat	182..222	CDD:293791	17/44 (39%)
		WD 6	217..263		20/46 (43%)
		WD40 repeat	237..274	CDD:293791	15/36 (42%)
		WD 7	267..316		12/53 (23%)
Rae1	NP_611597.1	WD40	<21..316	CDD:441893	111/297 (37%)
		WD40 repeat	25..66	CDD:293791	16/40 (40%)
		WD40 repeat	71..105	CDD:293791	12/33 (36%)
		WD40 repeat	113..150	CDD:293791	13/36 (36%)
		WD40 repeat	157..239	CDD:293791	32/84 (38%)
		WD40 repeat	255..293	CDD:293791	15/37 (41%)