DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZW10 and Zw10

DIOPT Version :9

Sequence 1:	NP_004715.1	Gene:	ZW10 / 9183	HGNCID:	13194	Length:	779	Species:	Homo sapiens
Sequence 2:	NP_524901.2	Gene:	Zw10 / 47874	FlyBaseID:	FBgn0004643	Length:	721	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	181/786 - (23%)
Similarity:	333/786 - (42%)	Gaps:	131/786 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    22 TRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLH 86
            ||::|...||.:       .|...|:||||:..|....:.:...|:.:|..:...:.||....|.
  Fly    37 TRVNRFQMRVRK-------HIEDNYTEFLPNNTSPDIFLEESGSLNREIHDMLENLGSEGLDALD 94

Human    87 VSTGEFTDLKQQLERDSVVLSL-----------LKQLQEFSTAIEEYNCAL----TEKKYVTGAQ 136
            .:..:.....:||.  .::|.|           |.|..|.:.|.::|...|    ..:.::.|..
  Fly    95 EANVKMAGNGRQLR--EILLGLGVSEHVLRIDELFQCVEEAKATKDYLVLLDLVGRLRAFIYGDD 157

Human   137 RLE-EAQ----KCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIVWK---FPPSK 193
            .:: :||    :..::.|:.:|::     ::.::..:|...:...|.|.:.:|:..:   ||.|:
  Fly   158 SVDGDAQVATPEVRRIFKALECYE-----TIKVKYHVQAYMLQQSLQERFDRLVQLQCKSFPTSR 217

Human   194 DTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSKLKSFGQMLLKYILRPLAS 258
            ..:...|..||:|....:...:|...|                  ::|..|   ||...:.|:..
  Fly   218 CVTLQVSRDQTQLQDIVQALFQEPYNP------------------ARLCEF---LLDNCIEPVIM 261

Human   259 CPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVLEVLQKQLLDLP-LDTDLENEKTS 322
            .|.:....|.......:|. |:....:.||.:::....:.|||.|:..|..|. ::..:..::
  Fly   262 RPVMADYSEEADGGTYVRL-SLSYATKEPSSAQLRPNYKQVLENLRLLLHTLAGINCSVSRDQ-- 323

Human   323 TVPLAEMLGDMIWEDLSECLIKNCLVYSIPTNSSKLQQYEEIIQSTEEFENALKEMRFLKGDTTD 387
              .:..::||.:.:.:.:.|:..||:.::| .|::..|...:.:...:.|..|.:...:..:...
  Fly   324 --HVFGIIGDHVKDKMLKLLVDECLIPAVP-ESTEEYQTSTLCEDVAQLEQLLVDSFIINPEQDR 385

Human   388 LL-KYARNINSHFANKKCQDVIVAARNLMTSEIHNTVKIIPDSKINVPELPTPDEDNKLEVQKVS 451
            .| ::.....:::.|:..:.|:..||.::..::.:.|.:.|
  Fly   386 ALGQFVEKYETYYRNRMYRRVLETAREIIQRDLQDMVLVAP------------------------ 426

Human   452 NTQYHEVMNLEPENTLDQHSFSLPTCRISESVKKLMELAYQTLLEATTS-SDQCAVQLFYSVRNI 515
            |....||.| :|        |..|.|.||:|.:..::|..:.|.:.|.. .||.|..:...:..:
  Fly   427 NNHSAEVAN-DP--------FLFPRCMISKSAQDFVKLMDRILRQPTDKLGDQEADPIAGVISIM 482

Human   516 FHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHLLTLGHQFRLRLAPILCDGTATFVDLVPG 580
            .|.:.:.||..|::.|:.:||.|.:.|||||:..|.:....::           |..:...|...
  Fly   483 LHTYINEVPKVHRKLLESIPQQAVLFHNNCMFFTHWVAQHANK-----------GIESLAALAKT 536

Human   581 FRRLGTECFLAQMRAQKGELLERLSSARNFSNMDDEENYSAAS---KAVRQVLHQLKRLGIVWQD 642
            .:..|.:.|..|:..|...|:..:      ...:.|..::..|   |.|||.|.||:.|..||.:
  Fly   537 LQATGQQHFRVQVDYQSSILMGIM------QEFEFESTHTLGSGPLKLVRQCLRQLELLKNVWAN 595

Human   643 VLPVNIYCKAMGTLLNTAISEVIGKITALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSEESKNK 707
            |||..:|......|:||.::|:|.::..|.|||.:....|..|...|:...|.:|...:|
  Fly   596 VLPETVYNATFCELINTFVAELIRRVFTLRDISAQMACELSDLIDVVLQRAPTLFREPNE----- 655

Human   708 KYQEEVPVYVPKWMPFKELMMMLQASLQEIGDRWADGKGPLAAAFSSSEVKALIRALFQNTERRA 772
                  .|.|..|:..::|..||.|||.||.:.|.||.|||.|::.|.|:|.|||||||:|:.||
  Fly   656 ------VVQVLSWLKLQQLKAMLNASLMEITELWGDGVGPLTASYKSDEIKHLIRALFQDTDWRA 714

Human   773 AALAKI 778
            .|:.:|
  Fly   715 KAITQI 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZW10	NP_004715.1	Interaction with RINT1	2..317		62/318 (19%)
		Interaction with ZWINT	2..81		15/58 (26%)
		Zw10	9..621	CDD:310684	118/624 (19%)
		PKc_like	<598..>768	CDD:328722	60/172 (35%)
Zw10	NP_524901.2	Zw10	20..574	CDD:283827	118/627 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151804
Domainoid	1	1.000	108	1.000	Domainoid score	I6465
eggNOG	1	0.900	-	-		E1_KOG2163
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4178
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55465
OrthoDB	1	1.010	-	-		D125408at33208
OrthoFinder	1	1.000	-	-		FOG0006350
OrthoInspector	1	1.000	-	-		oto91350
orthoMCL	1	0.900	-	-		OOG6_104989
Panther	1	1.100	-	-	LDO	PTHR12205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3777
SonicParanoid	1	1.000	-	-		X6070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800