DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYLK3 and CMK1

DIOPT Version :9

Sequence 1:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens
Sequence 2:	NP_116669.1	Gene:	CMK1 / 850568	SGDID:	S000001910	Length:	446	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	103/324 - (31%)
Similarity:	159/324 - (49%)	Gaps:	36/324 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDR----EDVKNEINIMNQLSHVNLIQLYDAF 579
            :.||.|.||.|.:.....||..:|.||:..|:.|..    |.:.:|::|:.:|.|.|::...|.|
Yeast    41 KTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWF 105

Human   580 ESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILC 644
            |||....::.:...||||||||. :|...||.|.|....:|...|.|:|...|:|.||||||:|.
Yeast   106 ESKDKFYIITQLAKGGELFDRIL-KKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLY 169

Human   645 VNQTGHQ-IKIIDFGLARRYKPREKLKVN-FGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLS 707
            ::::... :.:.|||:|:|.|..|:|... .|:..::||||:..:....|.|:||:|||||.||.
Yeast   170 IDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLC 234

Human   708 GLSPFLGETDAETMNFIVNCSW-----DFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKH 767
            |.|.|..|   ...:|:..|:.     .|....::.:|.:||.|:.:.|..:.|.|.:|.:.|:.
Yeast   235 GYSAFRAE---RVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLED 296

Human   768 EWL--------NNLPA-------------KASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAAN 810
            .|:        |.||.             ...|.:..:|.|.|...|:.|.:....|...:.||
Yeast   297 PWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNMKIQKLRDLYLEQTESDSDFDEGSQAN 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462
		STKc_MLCK3	510..770	CDD:271094	90/261 (34%)
		S_TKc	513..770	CDD:214567	90/261 (34%)
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	90/260 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910