Protein Alignment MYLK3 and CMK1

DIOPT Version :10

• Sequence 1: NP_872299.2
• Gene: MYLK3 / 91807
• HGNCID: 29826
• Length: 819
• Species: Homo sapiens
• Sequence 2: NP_116669.1
• Gene: CMK1 / 850568
• SGDID: S000001910
• Length: 446
• Species: Saccharomyces cerevisiae
• Alignment Length: 324
• Identity: 103/324 - (31%)
• Similarity: 159/324 - (49%)
• Gaps: 36/324 - (11%)

Human   519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDR----EDVKNEINIMNQLSHVNLIQLYDAF 579
            :.||.|.||.|.:.....||..:|.||:..|:.|..    |.:.:|::|:.:|.|.|::...|.|
Yeast    41 KTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWF 105

Human   580 ESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILC 644
            |||....::.:...||||||||. :|...||.|.|....:|...|.|:|...|:|.||||||:|.
Yeast   106 ESKDKFYIITQLAKGGELFDRIL-KKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLY 169

Human   645 VNQTGHQ-IKIIDFGLARRYKPREKLKVN-FGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLS 707
            ::::... :.:.|||:|:|.|..|:|... .|:..::||||:..:....|.|:||:|||||.||.
Yeast   170 IDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLC 234

Human   708 GLSPFLGETDAETMNFIVNCSW-----DFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKH 767
            |.|.|..|   ...:|:..|:.     .|....::.:|.:||.|:.:.|..:.|.|.:|.:.|:.
Yeast   235 GYSAFRAE---RVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLED 296

Human   768 EWL--------NNLPA-------------KASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAAN 810
            .|:        |.||.             ...|.:..:|.|.|...|:.|.:....|...:.||
Yeast   297 PWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNMKIQKLRDLYLEQTESDSDFDEGSQAN 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..256
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..462
		STKc_MLCK3	510..770	CDD:271094	90/261 (34%)
CMK1	NP_116669.1	STKc_CAMK	36..298	CDD:270687	90/260 (35%)