DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYLK3 and sqa

DIOPT Version :9

Sequence 1:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens
Sequence 2:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster

Alignment Length:	324	Identity:	147/324 - (45%)
Similarity:	219/324 - (67%)	Gaps:	31/324 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   485 VVLDDS-------PAPPAPFEHRVVSVKETSISAGYEVCQH-EVL---GGGRFGQVHRCTEKSTG 538
            :.:|||       ||.|         :::.:|:...:..:| :||   |.|:||.|::|.:|:.|
  Fly     2 IYIDDSEPEGVLEPAFP---------MRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANG 57

Human   539 LPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITD 603
            |.||||.:.:...:|:.:|:.|:.|||.|.|..:||||.|:|.:....:|:|.::|||||||:.|
  Fly    58 LQLAAKFVPIPKREDKRNVEREVEIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVD 122

Human   604 EKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREK 668
            :::.|||....:|.||:||.:.::|.:.|:||||||||||.:.|.|::||||||||||::.|.::
  Fly   123 DEFVLTERVCRVFIRQVCEAMAFIHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKR 187

Human   669 LKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDA 733
            |:|.||||||:||||||::.:|:.|||||||||.|:|:||||||:||.|.|||:.:....:||:.
  Fly   188 LRVLFGTPEFVAPEVVNFDCISYGTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFED 252

Human   734 DTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKA-----------SRSKTRLKS 786
            :.|.|:|.|..||:::||.|:.|.||:|.:|:||:||...||.|           :.||:||||
  Fly   253 ECFNGISPECLDFIAKLLAKDLSTRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462
		STKc_MLCK3	510..770	CDD:271094	129/263 (49%)
		S_TKc	513..770	CDD:214567	129/260 (50%)
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	128/254 (50%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	126/248 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	1	1.000	-	-		X2697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940