DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYLK3 and cmk1

DIOPT Version :9

Sequence 1:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens
Sequence 2:	NP_593464.1	Gene:	cmk1 / 2542442	PomBaseID:	SPACUNK12.02c	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	314	Identity:	113/314 - (35%)
Similarity:	164/314 - (52%)	Gaps:	27/314 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   516 CQH---EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDRED-VKNEINIMNQLS--HVNLIQ 574
            |::   .|||||.:..|.......|....||||:..|..:.::| |||||.|:.::|  |.|::.
pombe    29 CKYRVGRVLGGGTYATVREAVHIETNKMYAAKIMNKKMMEKKQDFVKNEIAILKRVSYEHPNILH 93

Human   575 LYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKP 639
            |.|.||:.::..|:.|...||||||||. .|....|.|.....|.....|.|||.:.|:|.||||
pombe    94 LVDFFETVNNLYLITELATGGELFDRIC-AKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKP 157

Human   640 ENILCVNQ-TGHQIKIIDFGLARRYKPRE--KLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVI 701
            ||:|..:: ....:.|.||||:..|:..:  .|....||||::||||........|.|||::|||
pombe   158 ENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVI 222

Human   702 TYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLK 766
            ||.||||.:||...:..|.:..|:...:.|:...:.|:||.||||:.:.|..:.|.|::|...||
pombe   223 TYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADALK 287

Human   767 HEWLNNLPAKASRSKTRLKSQLL---LQKYIAQRKWKKHFYVVTAANRLRKFPT 817
            |.:|:        .|....|.||   .:.:.|::.::      ||.|.:|.|.|
pombe   288 HPFLS--------EKRPATSNLLPNVRENFNARKTFR------TAYNAVRAFNT 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462
		STKc_MLCK3	510..770	CDD:271094	101/262 (39%)
		S_TKc	513..770	CDD:214567	101/262 (39%)
cmk1	NP_593464.1	STKc_CAMK	30..290	CDD:270687	100/260 (38%)
cmk1	NP_593464.1	S_TKc	31..291	CDD:214567	100/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910