DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MYLK3 and mlck-1

DIOPT Version :9

Sequence 1:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens
Sequence 2:	NP_509689.1	Gene:	mlck-1 / 181217	WormBaseID:	WBGene00013869	Length:	1211	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	154/359 - (42%)
Similarity:	227/359 - (63%)	Gaps:	32/359 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   477 PPGAEAGSVVLDDS-PA----PPA----PFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRC 532
            |.|  :|.:.:|:. |:    ||.    ..|:...:||..::   |:|.  ::||.|:||:|:..
Worm     5 PSG--SGKIKVDEHYPSELDEPPVFDVKKIENIRANVKFDTL---YQVT--KLLGDGKFGKVYCV 62

Human   533 TEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAF-ESKHSCTLVMEYVDGGE 596
            .||.||...|||.||::...||.:|:.|::|:.||.|..:.|:|||| .:.:...|:||.|.|||
Worm    63 IEKETGKEFAAKFIKIRKEADRAEVEREVSILTQLRHPRIAQIYDAFYTTTNDVVLIMEIVRGGE 127

Human   597 LFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLAR 661
            ||||:.:|.|.|:||.||:...|:||.:.|:|:..|||||:|||||:||:.||::||:|||||||
Worm   128 LFDRVAEESYVLSELAVVMIICQLCEAIDYIHKQNILHLDVKPENIMCVSLTGNRIKLIDFGLAR 192

Human   662 RYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVN 726
            .|...::||...|||||.||||:.:|.:.:.|||||:|||||:||||.|||||:...||...:..
Worm   193 HYDGTQELKYMAGTPEFAAPEVIKFEKLDYHTDMWSIGVITYILLSGYSPFLGDNLGETYCNVEK 257

Human   727 CSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWL---------NNLPAKASRSKT 782
            ..|:| .:.|:.::|||||||::|||.::|.||...:||:|.|:         |.:..|...:.|
Worm   258 GVWEF-TEEFDTVTEEAKDFVTKLLVYDQSKRMLPHECLQHPWIAKHRQKAACNTILEKPLNAPT 321

Human   783 RLKSQLLLQKYIAQRKWKKH-FYV--VTAANRLR 813
            ....|::  :|.|:||:::. .||  :...||||
Worm   322 LDNKQIM--RYNARRKFRRMIIYVKFLIEMNRLR 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462
		STKc_MLCK3	510..770	CDD:271094	129/260 (50%)
		S_TKc	513..770	CDD:214567	129/257 (50%)
mlck-1	NP_509689.1	PKc_like	51..300	CDD:389743	127/249 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4277
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900