DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYLK3 and mylk3

DIOPT Version :9

Sequence 1:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens
Sequence 2:	XP_002931740.3	Gene:	mylk3 / 100498243	XenbaseID:	XB-GENE-980367	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	849	Identity:	381/849 - (44%)
Similarity:	503/849 - (59%)	Gaps:	169/849 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    15 PGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGAD 79
            ||:    ::.||.|||:||||:|::|||||||..||:.:..:|..||:|:..|.|.|.|    :.
Frog    29 PGV----VSNMDKKLNLLNEKMDKILHFQEDVMGKLEYVHHNMDMLEKGMDMLAALRGP----SQ 85

Human    80 GVPH----IDTQAG---WPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKV 137
            .:.|    |....|   ...::.|::.:.:|:..|..:|::|.|||:.:|:.:|.||:|.:.||:
Frog    86 QILHENVDISQSPGHNSCSNLIRLLKLIHEDSVIHREKLDSLERMVSTMDKVVAFVGSTLRNSKI 150

Human   138 ADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAE 202
            .||:::|.|||::    :|.:|.|::.||:..|.|..|:....|.:|:...|:|:|:...|..::
Frog   151 VDFILKGTVPWKK----ESKDEAKDKSEEKEVKTKQGLNRGEGQVEAQRLNEDSRKSSAQEELSQ 211

Human   203 RL---PPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLEL 264
            :.   |.|:        ..:.||..:.....|.||.          .:|....|..||:|....
Frog   212 KATQSPTIK--------LDSTVSTLETSTYFGNAQG----------SKACVQRTEKENIRVAQH- 257

Human   265 APAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGG 329
                                .|.|::..|     |:.||                   :..|:.|
Frog   258 --------------------NQAATNQVP-----EQSTR-------------------QKDHNSG 278

Human   330 ---ETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTE--- 388
               |....:||     ...|.||...:.|....|.|              .|...|....||
Frog   279 TKEENHSSVSI-----SKSGSMLKLKQSSKEQVLRT--------------NTSEQLIIKKTELMT 324

Human   389 PGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLA---------------------- 431
            .|:.|         ::::|:..|:...:|..|   ...:|||:
Frog   325 LGKDT---------VKQTSAFHGIDISQEVVA---EDKQPSLSVKLGKVQPSFNKTTKCIKRQES 377

Human   432 ---------RSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVL 487
                     |:.|.|.      :|..:..|.|..|.:.|...:..|.::|         :...|:
Frog   378 CDKKSVGQQRTSDTDR------VQLTEDHGKGAEEHQIDIVKKKSVDSDA---------SFLHVI 427

Human   488 DDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGG-GRFGQVHRCTEKSTGLPLAAKIIKVKSA 551
            ||.|.|||||.||:||:|:..:|:.|.|.||||||| |||||||:|.||:|||.|||||||||.|
Frog   428 DDCPPPPAPFNHRIVSIKQAILSSCYSVSQHEVLGGRGRFGQVHKCIEKATGLQLAAKIIKVKGA 492

Human   552 KDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLF 616
            |||::||||||:||||:||||||||||||.|:..||:|||:||||||||||||.|.|||||.::|
Frog   493 KDRDEVKNEINVMNQLNHVNLIQLYDAFECKNDLTLIMEYLDGGELFDRITDENYSLTELDAIMF 557

Human   617 TRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAP 681
            |:|||||::||||.||||||||||||||||:||:|||||||||||||||||||||||||||||||
Frog   558 TKQICEGIYYLHQQYILHLDLKPENILCVNRTGNQIKIIDFGLARRYKPREKLKVNFGTPEFLAP 622

Human   682 EVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDF 746
            |||||:||||||||||||||||||||||||||||:||||||:||||:|||::::||.:|||||||
Frog   623 EVVNYDFVSFPTDMWSVGVITYMLLSGLSPFLGESDAETMNYIVNCNWDFESESFEQVSEEAKDF 687

Human   747 VSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANR 811
            :|:||:||:|||:||.|||||:||.|||.||.:.|.|||||:|||||:||:|||||||||.||||
Frog   688 ISKLLIKERSCRLSAGQCLKHDWLVNLPLKAMKYKVRLKSQILLQKYMAQKKWKKHFYVVAAANR 752

Human   812 LRKF 815
            |:||
Frog   753 LKKF 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334		38/193 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462		25/148 (17%)
		STKc_MLCK3	510..770	CDD:271094	212/260 (82%)
		S_TKc	513..770	CDD:214567	211/257 (82%)
mylk3	XP_002931740.3	PKc_like	450..711	CDD:419665	212/260 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	443	1.000	Domainoid score	I4895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H35278
Inparanoid	1	1.050	677	1.000	Inparanoid score	I5592
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118679at33208
OrthoFinder	1	1.000	-	-		FOG0000818
OrthoInspector	1	1.000	-	-		oto150407
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2697
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060