Protein Alignment ALKBH8 and TRM9

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_013698.1
• Gene: TRM9 / 854994
• SGDID: S000004476
• Length: 279
• Species: Saccharomyces cerevisiae
• Alignment Length: 308
• Identity: 110/308 - (35%)
• Similarity: 157/308 - (50%)
• Gaps: 44/308 - (14%)

Human   366 EASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMI 430
            :|:..||||||:||.|||.|||.||:.|||.:.:|||..|.|||..|:|||||||||:|.::|:|
Yeast     5 QAAEKEQEYVHKVYNEIAPHFSQTRYKPWPIVTQFLKTRPMGSIGIDVGCGNGKYLGVNPDIYII 69

Human   431 GCDRSQNLVDICR--ERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLL 493
            |.|||..|::..|  ...:...|.|.|.:|.::.:.|..|||||:||::|.||||..::.::..|
Yeast    70 GSDRSDGLIECARGINPSYNLLVADGLNLPHKNETFDFAISIAVVHHWSTRERRVEVIRHVLSKL 134

Human   494 RPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVP 558
            |.||:||||.||:||            ..:.:|..|.|..|..|...|.:..    |:....|.|
Yeast   135 RQGGQALIYCWALEQ------------GSSRRGYHEGMEQDVFVPWVLPKSK----SKPKTKSTP 183

Human   559 RINDSQEGGCNSRQVSNSKLPVHVNRTSFYSQDVLVPW--------HLKGNPDKGKPVEPFGPIG 615
                       ..:|.....|..:|.......:.|..|        .|..|.:|.:..:
Yeast   184 -----------PAKVKTRPKPNLMNIPPKERSEYLQRWKEEQQRSKSLDDNDEKQQQDQ------ 231

Human   616 SQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYDQGNWCVILQK 663
            .|:...|.:||||::|||||...||. :...:....:::.||.|:.||
Yeast   232 EQEREEVKYRYYHLYREGELAEDCRQ-AGAAVHSEGFERDNWWVVAQK 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570
		RRM_ALKBH8	42..122	CDD:409865
		2OG-FeII_Oxy	152..334	CDD:473886
		UbiE	379..505	CDD:441828	63/127 (50%)
		Methyltransferase domain	411..664		83/263 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		10/59 (17%)
TRM9	NP_013698.1	Methyltransf_11	50..142	CDD:462406	41/91 (45%)