Protein Alignment ALKBH8 and Alkbh8

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_001391965.1
• Gene: Alkbh8 / 67667
• MGIID: 1914917
• Length: 709
• Species: Mus musculus
• Alignment Length: 663
• Identity: 513/663 - (77%)
• Similarity: 568/663 - (85%)
• Gaps: 0/663 - (0%)

Human     1 MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVL 65
            |:.||:...||:|.||||||||.||:|.||:||||:.|||.|||||:|||||||||||.|||..|
Mouse    46 MNINHKGVLKLTKMEKKFLRKQSKARHVLLKHEGIQAVSYPTQSLVIANGGLGNGVSRKQLLLTL 110

Human    66 EKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKELRP 130
            ||||.|:||||||||||:|..::|.||||:||.||||||::|||||||.||||||||.|||.:..
Mouse   111 EKCGPVEALLMPPNKPYAFVIFQTIEESKKAYFTLNGKEIIDDLGQKIFLYLNFVEKAQWKNMGL 175

Human   131 QALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKP 195
            :||||||:||||||||||||.|||||:|||||.|||.|:|||||||||||||||||:|.||||||
Mouse   176 EALPPGLLVVEEIISSEEEKKLLESVNWTEDTGNQNFQRSLKHRRVKHFGYEFHYESNTVDKDKP 240

Human   196 LSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVM 260
            |.||||::|.|.|||.|::|||||||||:||||||||.||||||||||||||||:||||||.|||
Mouse   241 LPGGLPEVCSSILEKLLKEGYIKHKPDQLTINQYEPGHGIPAHIDTHSAFEDEIISLSLGSAIVM 305

Human   261 DFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKR 325
            |||||:|:.|.||||||||||||||||||||||||.||||||||||..|.||||||:||||||||
Mouse   306 DFKHPEGVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTVQASEQFKGGIITSDIGDLTLSKR 370

Human   326 GLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTR 390
            |:||||||||||:.||||||..|||.|||.||||..||.|||..|||::|||||.|||.||||||
Mouse   371 GMRTSFTFRKVRRMPCNCSYSSVCDRQRKATPPSLTESSKEALELEQKHVHQVYNEIASHFSSTR 435

Human   391 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDAL 455
            |:|||.|||||||||||||||||||||||||||||:|||||||||||||||||||||||.|||||
Mouse   436 HSPWPRIVEFLKALPSGSIVADIGCGNGKYLGINKDLYMIGCDRSQNLVDICRERQFQALVCDAL 500

Human   456 AVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRG 520
            ||||||||||||||||||||||||||||.||||:.|||||||:||||||||||||..||||||||
Mouse   501 AVPVRSGSCDACISIAVIHHFATAERRVEALQELARLLRPGGQALIYVWAMEQEYKNQKSKYLRG 565

Human   521 NRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRT 585
            .|.|||.|:|:||.||.:..||.|..:..:.|.|.||...:.::|....||:|.||:||:|:|||
Mouse   566 KRISQGDKDELNSATSTEEFLVNQTPEGVNEDPALSVNSSSITKEEEYKSRKVPNSELPIHINRT 630

Human   586 SFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQS 650
            .|:|||||||||||.||.|.|.:||.|..|..|||||||||||||.:||||.:|:.|.||.||||
Mouse   631 CFHSQDVLVPWHLKRNPGKDKAIEPSGVAGCPDPSPVFHRYYHVFCDGELEASCQAVGDVSILQS 695

Human   651 YYDQGNWCVILQK 663
            |||||||||:|||
Mouse   696 YYDQGNWCVVLQK 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	23/35 (66%)
		RRM_ALKBH8	42..122	CDD:409865	62/79 (78%)
		2OG-FeII_Oxy	152..334	CDD:473886	153/181 (85%)
		UbiE	379..505	CDD:441828	115/125 (92%)
		Methyltransferase domain	411..664		188/253 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		27/59 (46%)
Alkbh8	NP_001391965.1	ALKBH8_N	46..82	CDD:117570	23/35 (66%)
		RRM_ALKBH8	87..167	CDD:409865	62/79 (78%)
		2OG-FeII_Oxy	<229..379	CDD:473886	125/149 (84%)
		UbiE	424..550	CDD:441828	115/125 (92%)