Protein Alignment ALKBH8 and alkbh8

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: XP_009290865.1
• Gene: alkbh8 / 556362
• ZFINID: ZDB-GENE-100922-251
• Length: 666
• Species: Danio rerio
• Alignment Length: 676
• Identity: 385/676 - (56%)
• Similarity: 491/676 - (72%)
• Gaps: 35/676 - (5%)

Human     1 MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVL 65
            |:|:.  :.:.:|.|||.||:||||.||||:||.|.|||:.|:.|||:||||||||||..||.||
Zfish     1 MESSR--SVRRTKEEKKLLRRQIKASHTLLKHEDITTVSHPTKHLVVSNGGLGNGVSRESLLEVL 63

Human    66 EKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKELRP 130
            ::.|.|::||.||:|||:|..|.:.|..:.||..|||: .:....|.:|||.::|.||.......
Zfish    64 KEGGTVESLLTPPSKPYAFVSYSSIEAGQNAYTLLNGR-TLQCQDQTMTLYFSYVVKVDCDRSVS 127

Human   131 QALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKP 195
            .||||||.|:|:.:|.|||..:|::||||...|:..:||:||||||||:||||.|:|||||||||
Zfish   128 CALPPGLSVLEDFVSLEEELQILKAVDWTPHADDVTAQKALKHRRVKHYGYEFRYDNNNVDKDKP 192

Human   196 LSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVM 260
            |.||||..|::.|::.|..|:|...|||:|:|||:.|||||.|:||||.|||.|:|||||::.||
Zfish   193 LPGGLPVECDALLQRCLAGGHISVLPDQLTVNQYQSGQGIPPHVDTHSPFEDTILSLSLGAKTVM 257

Human   261 DFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKR 325
            |||||||.:|.|:||.||||||.||||||||||||.||||.|..||:..||::|||:.:||||:|
Zfish   258 DFKHPDGRSVAVVLPERSLLVMKGESRYLWTHGITPRKFDVVPVSETGGSGVMTSDLSNLTLSRR 322

Human   326 GLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTR 390
            ..|||.||||:|.|||||:||.||||||..:||..|.::.:|.|||.:|||||||||:.||||||
Zfish   323 DTRTSLTFRKIRHTPCNCAYPSVCDSQRPPSPPVVPVAEGDACRLESQYVHQVYEEISSHFSSTR 387

Human   391 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDAL 455
            |:|||.:.:||.:||.||.:||:|||||||||||..:..:|||||.|||.||.||.:.|||.|||
Zfish   388 HSPWPKVRDFLLSLPPGSFLADVGCGNGKYLGINPAVRAVGCDRSVNLVQICIERGYDAFVSDAL 452

Human   456 AVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLR- 519
            :||:|.|||||||||||||||||.|||.||::|::||::.||:|||||||||||||.||||||:
Zfish   453 SVPLRRGSCDACISIAVIHHFATQERRRAAVRELIRLIKVGGRALIYVWAMEQEYNNQKSKYLKE 517

Human   520 ---GNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVH 581
               |:....|::.:...:.::|:.  |..|:|        :..|..:.:|..|   |:..|:.||
Zfish   518 EASGSSREGGEELKTEENKAIQKE--EHDRNM--------ISDIRCTDDGLSN---VTQPKIHVH 569

Human   582 VNRTSFYSQDVLVPWHLKGNPDKGK---------PVEPFGPIGSQDPSPVFHRYYHVFREGELEG 637
            .|||:|.|||:|||||||||.:..|         |||      :....||||||||||::||||.
Zfish   570 TNRTAFLSQDLLVPWHLKGNMENKKGAASGCADIPVE------NAKQKPVFHRYYHVFQQGELEE 628

Human   638 ACRTVSDVRILQSYYDQGNWCVILQK 663
            .|..|..|::|:||:|||||||.|:|
Zfish   629 LCLGVKGVKVLRSYHDQGNWCVELEK 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	19/35 (54%)
		RRM_ALKBH8	42..122	CDD:409865	40/79 (51%)
		2OG-FeII_Oxy	152..334	CDD:473886	118/181 (65%)
		UbiE	379..505	CDD:441828	86/125 (69%)
		Methyltransferase domain	411..664		142/266 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		14/63 (22%)
alkbh8	XP_009290865.1	RRM_ALKBH8	40..119	CDD:409865	40/79 (51%)
		2OG-FeII_Oxy	133..331	CDD:473886	126/197 (64%)
		UbiE	398..502	CDD:441828	71/103 (69%)