Protein Alignment ALKBH8 and alkbh8

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: XP_012812512.2
• Gene: alkbh8 / 550051
• XenbaseID: XB-GENE-985927
• Length: 638
• Species: Xenopus tropicalis
• Alignment Length: 660
• Identity: 408/660 - (61%)
• Similarity: 500/660 - (75%)
• Gaps: 48/660 - (7%)

Human    10 KLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDAL 74
            ||||..||.|:||.||||.||:|||||||.:.:||||||||||||||||.|||.|||:||.|:.|
 Frog    20 KLSKDNKKLLKKQAKAKHILLKHEGIETVLHLSQSLVVANGGLGNGVSRQQLLAVLERCGKVETL 84

Human    75 LMPPNKPYSFARYRTTEESKRAYVTLNGKEVV-DDLGQKITLYLNFVEKVQWKELRPQALPPGLM 138
            ||||||||:|..|.:.||:.:||.:|:|:|:. :|..|.|||||:|||||..||:...:|||||:
 Frog    85 LMPPNKPYAFVTYSSAEEAIKAYSSLSGQELCGEDAEQPITLYLSFVEKVVVKEVLSPSLPPGLI 149

Human   139 VVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKPLSGGLPDI 203
            :||:.:|.|:|:.:|||:||..:|   :||||||||||||:||||.|:||||||||||.|||||.
 Frog   150 IVEDFVSPEQERTMLESIDWDSET---SSQKSLKHRRVKHYGYEFRYDNNNVDKDKPLPGGLPDF 211

Human   204 CESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVMDFKHPDGI 268
            |...|.|.::.|.|||.|||:||||||||||||.|:||||||||||:|||||:|||||||||:|.
 Frog   212 CTEALRKCVQIGLIKHDPDQLTINQYEPGQGIPPHVDTHSAFEDEILSLSLGAEIVMDFKHPNGS 276

Human   269 AVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKRGLRTSFTF 333
            .||||||:||||:|:||||||||||||.||||.:|.||....|.|:.:.|:||||||..||||||
 Frog   277 VVPVMLPQRSLLIMSGESRYLWTHGITPRKFDVIQVSEGQTVGTISGNSGELTLSKRSTRTSFTF 341

Human   334 RKVRQTPCNCSYPLVCDS---QRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWP 395
            ||||.:||:|::|..|||   |::::||:..|..  ||.||:||||:||::||||||||||||||
 Frog   342 RKVRHSPCDCAFPSECDSQQTQKEKSPPTVGELG--ASTLEREYVHKVYDDIAGHFSSTRHTPWP 404

Human   396 HIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAVPVR 460
            .|.:||.:||.||:|||:|||||||||:||:|.|||||||:|||||||||.|:|||||||:||.|
 Frog   405 KIGDFLASLPKGSLVADVGCGNGKYLGVNKDLCMIGCDRSKNLVDICRERTFEAFVCDALSVPFR 469

Human   461 SGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQ 525
            :|:.||||||||||||||.|||:|||||::||||.||||||||||:||||.|.|||||:.::.||
 Frog   470 AGAFDACISIAVIHHFATEERRIAALQELIRLLRKGGKALIYVWALEQEYKKNKSKYLKESKTSQ 534

Human   526 G-KKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSFYS 589
            | ..:.:.::.:|:                                     :.||:|.|||||:|
 Frog   535 GPSSDALGTNLAVK-------------------------------------APLPIHTNRTSFHS 562

Human   590 QDVLVPWHLK-GNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYD 653
            ||:||||||| .|..|..|...........|..|:||:||||.|||||..|..:|:|.:..||:|
 Frog   563 QDLLVPWHLKPTNKSKVTPENKEQNEKEHGPDSVYHRFYHVFCEGELEAMCNRLSNVAVQHSYHD 627

Human   654 QGNWCVILQK 663
            ||||||||:|
 Frog   628 QGNWCVILEK 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	19/26 (73%)
		RRM_ALKBH8	42..122	CDD:409865	52/80 (65%)
		2OG-FeII_Oxy	152..334	CDD:473886	130/181 (72%)
		UbiE	379..505	CDD:441828	99/125 (79%)
		Methyltransferase domain	411..664		141/255 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		8/60 (13%)
alkbh8	XP_012812512.2	RRM_ALKBH8	52..130	CDD:409865	50/77 (65%)
		2OG-FeII_Oxy	147..342	CDD:473886	137/197 (70%)
		UbiE	388..514	CDD:441828	99/125 (79%)