Protein Alignment ALKBH8 and CG17807

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_611690.2
• Gene: CG17807 / 37585
• FlyBaseID: FBgn0034748
• Length: 615
• Species: Drosophila melanogaster
• Alignment Length: 684
• Identity: 284/684 - (41%)
• Similarity: 380/684 - (55%)
• Gaps: 105/684 - (15%)

Human     6 QSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGL 70
            ::..|::|. ||..:||.:....:.....:...:..|..|.|.|.||.||::        |:|.|
  Fly     5 ETQQKVNKA-KKADKKQRRCLAIIKSDCEVSPSAEPTPYLAVLNVGLSNGLT--------EECLL 60

Human    71 VDA---------LLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQK-ITLYLNFVE---- 121
            .:|         ::|.|.|.|.|....:.|:|:..|   .|...:..:||: ...||:::.
  Fly    61 TEAAATGGKVIQVVMLPGKSYCFFICASLEDSQLIY---EGMHNISTIGQQGAVAYLSYIRQLPA 122

Human   122 ---KVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEF 183
               |.:|.    :.||.||.::.:.::.|||..||.::.  ||........|||||.|||||:||
  Fly   123 LAGKSEWN----KPLPRGLHIIADFVTEEEESTLLRAIG--EDGRTSEVTGSLKHRNVKHFGFEF 181

Human   184 HYENNNVDKDKPLSGGLPDICE-------SFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDT 241
            .|..||||..|||...:|..|:       ||...|     ....|||:|:|:||||.|||.|:||
  Fly   182 LYGTNNVDPSKPLEQSIPSACDILWPRLNSFASTW-----DWSSPDQLTVNEYEPGHGIPPHVDT 241

Human   242 HSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASE 306
            ||||.|.|:||||.|::||||:..|. .|.|.|||||||:|:||:||.|||||..:..|
  Fly   242 HSAFLDPILSLSLQSDVVMDFRRGDD-QVQVRLPRRSLLIMSGEARYDWTHGIRPKHID------ 299

Human   307 SLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPES-DKEASRL 370
                 ::.|..|.||...||.|||.|||::|:.||:||||.:||:|:.:.|.....| ..:|..|
  Fly   300 -----VVPSASGGLTTQARGKRTSLTFRRLRKGPCDCSYPALCDTQQTKVPQELHASLAAQAITL 359

Human   371 EQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRS 435
            ||:.||:||::||.|||.|||||||.:.|||.:....|:|.||||||||||..|..|..:||||:
  Fly   360 EQQNVHEVYDKIADHFSETRHTPWPQVSEFLDSFEPQSVVLDIGCGNGKYLSCNPLLLSVGCDRA 424

Human   436 QNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKAL 500
            |.|:.:.|.:....|.||.|.|||||.|.|.|||||||||.||.|||:|||||:.|:|||||:||
  Fly   425 QGLLAVGRRKGQNVFRCDCLVVPVRSSSIDGCISIAVIHHLATKERRLAALQEMARVLRPGGRAL 489

Human   501 IYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQE 565
            :||||.:|..|.:||.|||  :|....||.    |:.|:...:|.:::
  Fly   490 VYVWAKDQRKNDKKSTYLR--QNKAVNKER----TTEQQQRQKQHQEL----------------- 531

Human   566 GGCNSRQVSNSK-LPVHVNRTSFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHV 629
                .:|:||:. ||||.|||.|..|||||||..|                 .:....:.|||||
  Fly   532 ----EQQLSNNNPLPVHTNRTEFQQQDVLVPWKTK-----------------DEQKTTYLRYYHV 575

Human   630 FREGELEGACRTVSDVRILQSYYDQGNWCVILQK 663
            |.|.|||.....|.:|::::|||||||.|.|.:|
  Fly   576 FEEQELENLVSQVHEVQLIKSYYDQGNHCAIFEK 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	6/30 (20%)
		RRM_ALKBH8	42..122	CDD:409865	25/96 (26%)
		2OG-FeII_Oxy	152..334	CDD:473886	90/188 (48%)
		UbiE	379..505	CDD:441828	77/125 (62%)
		Methyltransferase domain	411..664		115/254 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		11/59 (19%)
CG17807	NP_611690.2	RRM_ALKBH8	40..119	CDD:409865	25/89 (28%)
		2OG-FeII_Oxy	136..322	CDD:473886	95/204 (47%)
		UbiE	368..498	CDD:441828	79/129 (61%)