Protein Alignment ALKBH8 and Alkbh8

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: XP_063118302.1
• Gene: Alkbh8 / 366783
• RGDID: 1304687
• Length: 673
• Species: Rattus norvegicus
• Alignment Length: 672
• Identity: 510/672 - (75%)
• Similarity: 564/672 - (83%)
• Gaps: 9/672 - (1%)

Human     1 MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVL 65
            |:.||:...||:|.||||||||.||:|.||:||||:.|||.|||||:|||||||.|||.|||..|
  Rat     1 MNINHEGVLKLTKMEKKFLRKQSKARHVLLKHEGIQAVSYPTQSLVIANGGLGNAVSRKQLLLTL 65

Human    66 EKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKELRP 130
            ||||.|:||||||||||:|..::|.||||:||..|||||::|||||||.||||||||.|||:|..
  Rat    66 EKCGPVEALLMPPNKPYAFVIFQTIEESKKAYSILNGKEIIDDLGQKIFLYLNFVEKAQWKKLGL 130

Human   131 QALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKP 195
            |||||||:||||||||||||||||||:|||||.||:.|:|||||||||||||||||||.||||||
  Rat   131 QALPPGLLVVEEIISSEEEKMLLESVNWTEDTGNQHFQRSLKHRRVKHFGYEFHYENNTVDKDKP 195

Human   196 LSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVM 260
            |.||||:||.|.|||.|::|||||||||:||||||||.|||||||:|||||.|||||||||.|||
  Rat   196 LPGGLPEICSSILEKLLKEGYIKHKPDQLTINQYEPGHGIPAHIDSHSAFEHEIVSLSLGSAIVM 260

Human   261 DFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKR 325
            |||||:|:.|.||||||||||||||||||||||||.|||||:||||..|.|||.||:||||||||
  Rat   261 DFKHPEGVTVQVMLPRRSLLVMTGESRYLWTHGITPRKFDTIQASEQFKGGIINSDIGDLTLSKR 325

Human   326 GLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTR 390
            |:||||||||||:.||||||..|||.|||.||||..||.|||..|||::||.||:|||.||||||
  Rat   326 GMRTSFTFRKVRRIPCNCSYSSVCDRQRKATPPSLLESSKEALELEQKHVHHVYDEIASHFSSTR 390

Human   391 HTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDAL 455
            |:|||.|||||||||||||||||||||||||||||||||||||||:|||||||||||||.|||||
  Rat   391 HSPWPRIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSRNLVDICRERQFQALVCDAL 455

Human   456 AVPVRSGSCDACISIAVIHHFATA---------ERRVAALQEIVRLLRPGGKALIYVWAMEQEYN 511
            ||||||||||||||||||||||||         ||||.|||||.||||.||:||||||||||||.
  Rat   456 AVPVRSGSCDACISIAVIHHFATAVSVAFPSVKERRVEALQEIARLLRSGGQALIYVWAMEQEYR 520

Human   512 KQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNS 576
            .||||||:|||.|||.|.|:||.||:::.||.||.:..|.|...||...|::::..|.||:|.||
  Rat   521 DQKSKYLKGNRISQGDKGELNSATSMEQLLVNQMPEGVSEDPGLSVHSSNNTKDEECKSRKVLNS 585

Human   577 KLPVHVNRTSFYSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRT 641
            :||:|.|||.|:||||||||||||.|.|.|.||..|.....||.||||||||||..||||.:|:.
  Rat   586 ELPIHTNRTCFHSQDVLVPWHLKGKPGKDKAVEQSGLARCPDPRPVFHRYYHVFCNGELEASCQA 650

Human   642 VSDVRILQSYYDQGNWCVILQK 663
            |.||.||||:||||||||:|||
  Rat   651 VGDVSILQSFYDQGNWCVVLQK 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	23/35 (66%)
		RRM_ALKBH8	42..122	CDD:409865	60/79 (76%)
		2OG-FeII_Oxy	152..334	CDD:473886	151/181 (83%)
		UbiE	379..505	CDD:441828	115/134 (86%)
		Methyltransferase domain	411..664		187/262 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		29/59 (49%)
Alkbh8	XP_063118302.1	None