Protein Alignment ALKBH8 and trm9

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_593681.1
• Gene: trm9 / 2542906
• PomBaseID: SPAC13D6.03C
• Length: 228
• Species: Schizosaccharomyces pombe
• Alignment Length: 297
• Identity: 111/297 - (37%)
• Similarity: 141/297 - (47%)
• Gaps: 79/297 - (26%)

Human   371 EQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRS 435
            |.|||||||::||.|||.||:.|||.:.:|||:||.||:..|||||||||..:|..:||||.||.
pombe     6 ENEYVHQVYDKIATHFSDTRYKPWPVVEKFLKSLPLGSVGVDIGCGNGKYQKVNPNVYMIGSDRC 70

Human   436 QNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKAL 500
            ..||.|. .......:.|.|.||..|...|..:||||||||:...||:.|:||::|.|..|||||
pombe    71 VKLVKIA-SNLGPMVISDGLHVPHPSNRFDFALSIAVIHHFSNENRRLQAVQEVLRPLVKGGKAL 134

Human   501 IYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQE 565
            .:|||:||:
pombe   135 FFVWALEQK-------------------------------------------------------- 143

Human   566 GGCNSRQVSNSKLPVHVNRTSFYSQDVLVPWHLKGNPD--KGKPVEPFGPIGSQDPSP--VFHRY 626
               |||:..:...|          |||.|||.||...:  ..||.|    :...||:.  .:.||
pombe   144 ---NSRRGFSEDGP----------QDVYVPWILKRQYEYPNAKPEE----LKGHDPAENIAYQRY 191

Human   627 YHVFREGELEGACRTVSDVRILQSYYDQGNWCVILQK 663
            ||:||:|||.....|... .||:..||:.||.||.:|
pombe   192 YHLFRKGELNELVETAGG-SILEHGYDRDNWWVIAEK 227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570
		RRM_ALKBH8	42..122	CDD:409865
		2OG-FeII_Oxy	152..334	CDD:473886
		UbiE	379..505	CDD:441828	64/125 (51%)
		Methyltransferase domain	411..664		86/257 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		3/59 (5%)
trm9	NP_593681.1	Methyltransf_11	46..135	CDD:462406	44/89 (49%)