Protein Alignment ALKBH8 and alkb-8

DIOPT Version :10

• Sequence 1: NP_620130.2
• Gene: ALKBH8 / 91801
• HGNCID: 25189
• Length: 664
• Species: Homo sapiens
• Sequence 2: NP_497751.1
• Gene: alkb-8 / 175476
• WormBaseID: WBGene00007581
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 661
• Identity: 235/661 - (35%)
• Similarity: 342/661 - (51%)
• Gaps: 103/661 - (15%)

Human    17 KFLRKQIKAKHTLLRHE-GIETVSYATQSLVVANGGLGNGVSRNQL----LPVLEKCGLVDALLM 76
            |..:|..|:...|.||: .::..:..|:.|:|:|..:..|||..:|    ||:.|   |.:.::.
 Worm    19 KLAKKVHKSIEQLKRHDPDVQISTEPTKYLLVSNSSILCGVSLEELEEIFLPLDE---LAEFIVY 80

Human    77 PPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQK-----ITLYLNFVEKVQWKELRPQALPPG 136
            |..:.|||.:..:.|:|.:....|:|. :...|...     |:...|..|..:.::.|    |..
 Worm    81 PNKRSYSFVQCSSIEKSIQVRTELHGL-IPPSLKNSHQPFAISYVENLPEATKCEDFR----PAN 140

Human   137 LMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFGYEFHYENNNVDKDKPLSGGLP 201
            |.::||.:||:.||.|::.|      .|..|.:|||||.|.|||:.|.|..|:..:.|. :..:|
 Worm   141 LKIIEEYVSSDLEKELVDLV------TNHPSVQSLKHRAVVHFGHVFDYSTNSASEWKE-ADPIP 198

Human   202 DICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEIVMDFKHPD 266
            .:..|.:::.:...||..:|||:|.|.||.|.|||:|.||||||:|.|||:||.|::||:||  |
 Worm   199 PVINSLIDRLISDKYITERPDQVTANVYESGHGIPSHYDTHSAFDDPIVSISLLSDVVMEFK--D 261

Human   267 GI----AVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESLKSGIITSDVGDLTLSKRGL 327
            |.    ..||:|..|||.::.|||||.|.|||..||:|.              |.....:..|..
 Worm   262 GANSARIAPVLLKARSLCLIQGESRYRWKHGIVNRKYDV--------------DPRTNRVVPRQT 312

Human   328 RTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSFPESDKEASRLEQEYVHQVYEEIAGHFSSTRHT 392
            |.|.|.||:|:.||.|.:...||..|| ...|.|.::..|.:||..||..|||.||.||..|||:
 Worm   313 RVSLTLRKIRRKPCECEWKEFCDWDRK-GEMSVPSNEDLALKLENSYVSDVYENIASHFDETRHS 376

Human   393 PWPHIVEFLKALPSGSIVADIGCGNGKYLGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAV 457
            .|..:.:|:..:|.||::.|:||||||||.....|..||||....|.||.|::......|||||:
 Worm   377 SWKAVKQFINEIPRGSVMYDVGCGNGKYLIPKDGLLKIGCDMCMGLCDIARKKDCHVARCDALAL 441

Human   458 PVRSGSCDACISIAVIHHFATAERRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNR 522
            |.|..|.||.|||||:||.||.|||...::|::|:::||.|..:.||:|:|    .:|:|.:
 Worm   442 PFRYESADAAISIAVLHHIATFERRKRLIEELLRVVKPGSKICVTVWSMDQ----SQSEYAK--- 499

Human   523 NSQGKKEEMNSDTSVQRSLVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSF 587
                                  ||  |::|..::.|.::..:      .|.:| :|.||..: .|
 Worm   500 ----------------------MR--GNKDDVAAAPAVSSEE------TQTTN-RLKVHDGK-DF 532

Human   588 YSQDVLVPWHLKGNPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYY 652
            ..|||||||.:   ..||:               .|.||||||||||.|....:|...:::....
 Worm   533 EQQDVLVPWTI---DQKGE---------------TFLRYYHVFREGEAEKLIESVQGCKLISVEK 579

Human   653 DQGNWCVILQK 663
            :|||:.:|.:|
 Worm   580 EQGNYIIIAKK 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH8	NP_620130.2	ALKBH8_N	1..37	CDD:117570	6/20 (30%)
		RRM_ALKBH8	42..122	CDD:409865	23/88 (26%)
		2OG-FeII_Oxy	152..334	CDD:473886	75/185 (41%)
		UbiE	379..505	CDD:441828	60/125 (48%)
		Methyltransferase domain	411..664		89/253 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..575		8/59 (14%)
alkb-8	NP_497751.1	RRM_SF	45..125	CDD:473069	22/83 (27%)
		2OG-FeII_Oxy	159..319	CDD:473886	74/182 (41%)
		UbiE	363..489	CDD:441828	60/125 (48%)