DRSC/TRiP Functional Genomics Resources

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Protein Alignment NEK9 and Rcc1

DIOPT Version :10

Sequence 1:NP_001316166.1 Gene:NEK9 / 91754 HGNCID:18591 Length:991 Species:Homo sapiens
Sequence 2:NP_523943.1 Gene:Rcc1 / 38669 FlyBaseID:FBgn0002638 Length:547 Species:Drosophila melanogaster


Alignment Length:645 Identity:143/645 - (22%)
Similarity:246/645 - (38%) Gaps:158/645 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   299 ADELLDRPLLRKRRR-----EMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKS- 357
            |.|...:|...||.|     |:.::.|:|.                .|:.....:|...|.|:. 
  Fly    13 AGEAEQQPPKAKRARIAFHLELPKRRTVLG----------------NVLVCGNGDVGQLGLGEDI 61

Human   358 -TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH--GDKASYRQPKH 419
             ..::|..:.....|..:.||..|..|:|...::|::     |....|.||.  .:..|..:|..
  Fly    62 LERKRLSPVAGIPDAVDISAGGMHNLVLTKSGDIYSF-----GCNDEGALGRDTSEDGSESKPDL 121

Human   420 VEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGS--DYYGCMGVDKVAGPEVLEPMQLNFFLSNPV 482
            :: |.|||: .:|.||..:.|:.::|:::|:||  |.:|.||: .:.|.:           ..|:
  Fly   122 ID-LPGKAL-CISAGDSHSACLLEDGRVFAWGSFRDSHGNMGL-TIDGNK-----------RTPI 172

Human   483 E--------QVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVD 539
            :        .::.|.:|:|:||...:|::.||.|.|:...:|....:|. |...:.|...|.::.
  Fly   173 DLMEGTVCCSIASGADHLVILTTAGKVFTVGCAEQGQLGRLSERSISGE-GRRGKRDLLRPTQLI 236

Human   540 VPKALIIVAVQCGCDGTFLL-TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLA 603
            :.:|....|:......||:. :|:..:.|.|||.|.:|.              ||       |..
  Fly   237 ITRAKPFEAIWATNYCTFMRESQTQVIWATGLNNFKQLA--------------HE-------TKG 280

Human   604 KQLSFYKIRT-------IAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYK---------KRLGI 652
            |:.:...|:|       ||.|:.||..:....:....|..:.|:||:|:.|         |:|  
  Fly   281 KEFALTPIKTELKDIRHIAGGQHHTVILTTDLKCSVVGRPEYGRLGLGDVKDVVEKPTIVKKL-- 343

Human   653 NLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIF- 716
                    .::::.|.||:..:.|.|.|..:::||:|.|.:|.:     ..|.|..    .||. 
  Fly   344 --------TEKIVSVGCGEVCSYAVTIDGKLYSWGSGVNNQLGV-----GDGDDEL----EPIVV 391

Human   717 ------GSLHHVPDLSCRGWHTILIV-----EKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGG 770
                  |.  |:...|..|.|.|.:|     ::..|.....|.||.:|    .:..:|.......
  Fly   392 VSKNTQGK--HMLLASGGGQHAIFLVKADKQDQKENVPVKVSGSSSIS----KKDKTPPQDNVDK 450

Human   771 GGEEEDSQQESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIP 835
            ..|..|.|::.|          .:.|........:.|....|::           ||.||.:...
  Fly   451 EAENVDKQEQKE----------NLPAKASTSSKKNKTPPQDNAD-----------KEAENVDKQE 494

Human   836 MPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGT 895
            ..:: .|..|:.|..:..|.|.::      |:|...|...|.........||....||.|
  Fly   495 QKEN-LPAKASTSSKKIKTPPQDD------AAEEVEEESAQEPTPKKAKKPAAKRGGKKT 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NEK9NP_001316166.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..43
STKc_Nek9 51..308 CDD:270860 3/8 (38%)
ATS1 372..763 CDD:444065 102/431 (24%)
RCC1 1 388..444 15/57 (26%)
RCC1 2 445..498 15/62 (24%)
RCC1 4 563..627 17/70 (24%)
RCC1 5 628..680 13/60 (22%)
RCC1 6 681..738 16/68 (24%)
Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501 744..903 30/152 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..795 6/42 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..853 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..991
Rcc1NP_523943.1 ATS1 42..389 CDD:444065 94/422 (22%)
Borrelia_P83 <419..>508 CDD:114011 20/114 (18%)
Blue background indicates that the domain is not in the aligned region.

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