Protein Alignment NEK9 and CG3862

DIOPT Version :10

• Sequence 1: NP_001316166.1
• Gene: NEK9 / 91754
• HGNCID: 18591
• Length: 991
• Species: Homo sapiens
• Sequence 2: NP_608550.1
• Gene: CG3862 / 33261
• FlyBaseID: FBgn0031286
• Length: 454
• Species: Drosophila melanogaster
• Alignment Length: 445
• Identity: 100/445 - (22%)
• Similarity: 159/445 - (35%)
• Gaps: 135/445 - (30%)

Human   332 STVTEAPIAVVTSRTSEVYVWGG------GKST---------------PQKLDVIKSGCSARQVC 375
            |.:.|.......|....|||||.      |..|               |.:|. ..:......|.
  Fly    29 SKIKEYSPKTTDSHEHRVYVWGFQETGALGLQTNVKKAKERYTEMVHHPTRLQ-FSNNNEITDVA 92

Human   376 AGNTHFAVVTVEKELYTWVNMQGGTKLHG-------QLGHGDKASYRQPKHVE-----------K 422
            || ..|.|..        ||...|..|.|       |||...|.:...|.:::           :
  Fly    93 AG-YGFTVYA--------VNRDDGETLFGSGLNTDSQLGFQVKGNPNDPANLDVIIYPTAIKLPR 148

Human   423 LQGKA-----IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG-------------------VDKV 463
            :||:.     ::.:|.|....|.:|..|.::..|::.||..|                   .:.:
  Fly   149 VQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGNNSYGQCGRSIIEEERYSKSALIHRISQEDI 213

Human   464 AGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYS--WGC-GEYGRGSLVSVHFFTGRLG 525
            .|.|            :.|.||.||.:|.:.||:...:|:  ||. |:.|:|
  Fly   214 CGKE------------DEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTGQG------------- 253

Human   526 LDSEEDYYTPQKV-----DVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGI 585
                 :|:|..::     ||.|.. ||.:.|..|....|.::|.....|.:|:.:|..::.....
  Fly   254 -----NYHTAGQITLIGGDVEKEK-IVRLSCSSDCVLALNEAGDAFGWGNSEYGQLDDSELAETQ 312

Human   586 INHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 650
            ||      :|.....|    .|..||:.:|.|.:...|::::|.:.|:|   .|.||.|.:.::.
  Fly   313 IN------IPRALKLT----KSIGKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPFVEQT 364

Human   651 G--INLLGGPLGGKQ-------VIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 696
            .  .:|| .||.|:.       |:.:.||.....|...|..:|.||....|.|.:
  Fly   365 SKPQHLL-PPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGL 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..43
		STKc_Nek9	51..308	CDD:270860
		ATS1	372..763	CDD:444065	88/384 (23%)
		RCC1 1	388..444		16/78 (21%)
		RCC1 2	445..498		15/71 (21%)
		RCC1 4	563..627		14/63 (22%)
		RCC1 5	628..680		16/60 (27%)
		RCC1 6	681..738		5/16 (31%)
		Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..991
CG3862	NP_608550.1	RCC1	43..99	CDD:395335	13/57 (23%)
		ATS1	89..449	CDD:444065	88/384 (23%)