DRSC/TRiP Functional Genomics Resources

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Protein Alignment NEK9 and HERC2

DIOPT Version :10

Sequence 1:NP_001316166.1 Gene:NEK9 / 91754 HGNCID:18591 Length:991 Species:Homo sapiens
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:748 Identity:169/748 - (22%)
Similarity:278/748 - (37%) Gaps:209/748 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   314 EMEEKVTLLNAPTKRPR-SSTVTE-APIAV--------VTSRTSEVYVWGGGKS----------- 357
            :.|:...|..:..|.|. |.|::. .||.:        :.|:..:||..|.|.:           
  Fly  2995 DKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNV 3059

Human   358 -TPQKLDVIKSGCSAR-QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV 420
             .|.:|.|::.....: .|.:|..|...:|::.::::|     |....|:||||::.:..:|:.|
  Fly  3060 PLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSW-----GEGEDGKLGHGNRTTLDKPRLV 3119

Human   421 EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEV--LEPMQLNFFLSNPVE 483
            |.|:.|.||.|:||...:..::.:|:||.:|...||.:|    .|...  |:|..:.......|.
  Fly  3120 EALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG----HGDNTTQLKPKLVTALAGRRVV 3180

Human   484 QVSCG--DNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDVPKALII 546
            ||:||  |...:.||.:..|:|||.|::            |:||....|...||.:::....:.:
  Fly  3181 QVACGSRDAQTLALTEDGAVFSWGDGDF------------GKLGRGGSEGSDTPHEIERLSGIGV 3233

Human   547 VAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLN--------QCMSGIINHEAYHEVPYTTSFTLA 603
            |.::||...:..||::|:|...|..::.:||..        |.:.|:......|           
  Fly  3234 VQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIH----------- 3287

Human   604 KQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGINLLGGPLGGKQVIRV 667
                      :|.|..|..|:.:.|::..:|.|..||.|.|| :..:....::|  |....|.||
  Fly  3288 ----------VAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIG--LDAVFVNRV 3340

Human   668 SCGDEFTIAATDDNHIFAWG--NGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGW 730
            :||         .:|..|||  |..:       .|...|....:|...|:.||...:  ......
  Fly  3341 ACG---------SSHSIAWGLPNASS-------DEEKRGPVPFSSTRDPLGGSSLGI--YEAETM 3387

Human   731 HTILIVEKVLNSKTIRSNSSGL--------SIGTVFQSSS------------------PGGGGGG 769
            .|:....|.||..:: |.|..|        ::|.|.::.|                  .....|.
  Fly  3388 QTLKQEAKPLNQSSL-SESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGA 3451

Human   770 GGGEEED---------SQQESETPDPSGGFRGTMEADRGMEGLISPTEAM----GNSNGASSSCP 821
            .||||:.         ..|.:||....||.......|.|::. .||..|:    |..:|.:::.|
  Fly  3452 VGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQE-HSPEAAVDALTGGMSGGANTLP 3515

Human   822 GWLRKELENAEFIPMPDSPSPLSA--------AFSES-EKDTLPYEELQGLKVAS---------- 867
                           |.|..||||        :.|.| ....||..:...:..::          
  Fly  3516 ---------------PLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQ 3565

Human   868 -EAPLEH---------------KPQVEASSPRLNPAVTCAGKGTPLT--------------PPAC 902
             |..|.|               :|:.::....|..|| |...|.|.|              .||.
  Fly  3566 QEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAV-CGRCGPPSTSQTIADTLISLGAGTPAV 3629

Human   903 ACSSLQVEVERLQGLVLK--CLAEQQK-LQQEN 932
            |...|:..:..|:.|...  ||.:..| :.||:
  Fly  3630 AAMLLETCITELEDLCTSRHCLGKLPKPVMQES 3662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NEK9NP_001316166.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..43
STKc_Nek9 51..308 CDD:270860
ATS1 372..763 CDD:444065 103/432 (24%)
RCC1 1 388..444 17/55 (31%)
RCC1 2 445..498 18/56 (32%)
RCC1 4 563..627 12/71 (17%)
RCC1 5 628..680 15/52 (29%)
RCC1 6 681..738 12/58 (21%)
Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501 744..903 47/246 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..795 14/77 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..853 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..991
HERC2NP_608388.2 ATS1 625..>894 CDD:444065
Cyt-b5 1292..1364 CDD:459698
MIB_HERC2 1928..1988 CDD:461991
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:463286
APC10-HERC2 2762..2932 CDD:176485
ATS1 2987..3320 CDD:444065 90/366 (25%)
RCC1 3302..3350 CDD:395335 16/58 (28%)
ATS1 4050..4389 CDD:444065
HECTc 4509..4880 CDD:238033
Blue background indicates that the domain is not in the aligned region.

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