DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK9 and ire1

DIOPT Version :9

Sequence 1:	NP_001316166.1	Gene:	NEK9 / 91754	HGNCID:	18591	Length:	991	Species:	Homo sapiens
Sequence 2:	NP_593384.1	Gene:	ire1 / 2542776	PomBaseID:	SPAC167.01	Length:	1072	Species:	Schizosaccharomyces pombe

Alignment Length:	338	Identity:	89/338 - (26%)
Similarity:	147/338 - (43%)	Gaps:	85/338 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    43 GAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEV--DLTRLSEKERRDALNEIVILAL 105
            |:.....|...| .|:|.|:.| ..:||...:|..|..|.|  :...|:.:|          :.|
pombe   646 GSVTVNSLTVYP-EVIGYGSHG-TIVYRGVYEDREVAVKRVLMEFYDLASRE----------ITL 698

Human   106 LQ----HDNIIAYY-----NHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIV 161
            ||    |.||:.||     :.|:   .::|||..||..:|.:|.:.. |.||:...:|..|:||.
pombe   699 LQQSDNHPNIVRYYCKQKSDQFL---YIVIELCKCNLSDLIEKPIAY-DDLFKSIDLVSLLYQIA 759

Human   162 SAVSCIHKAGILHRDIKTLNIFL---TKANLIK------LGDYGLAKKLN-SEYSMAET---LVG 213
            ..||.:|...::|||:|..||.|   ...||.|      :.|:||:|||: ::.|:..|   ..|
pombe   760 FGVSHLHSLDLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAG 824

Human   214 TPYYMSPELCQG----------VK--------YNFKSDIWAVGCVIFELLT-----LKRTFDATN 255
            :..:.|||:..|          ||        .:..:||:|:||:.:..||     ....:|...
pombe   825 SYGWRSPEILSGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEG 889

Human   256 PL---NLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLL---RKR--- 311
            .:   |.|:..:|.:       .:..:....::...:..:|.:|||.:.:|:.||.   .|:
pombe   890 NILKGNYCLVHLQSL-------GECGVLAADLIEDMIAFEPSKRPTIEVVLNHPLFWDYAKKLDF 947

Human   312 ------RREMEEK 318
                  |.|:||:
pombe   948 LIDVSDRFEVEER 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..43		89/338 (26%)
		STKc_Nek9	51..308	CDD:270860	81/306 (26%)
		S_TKc	52..308	CDD:214567	81/305 (27%)
		RCC1 1	388..444
		RCC1	389..441	CDD:278826
		RCC1	444..495	CDD:278826
		RCC1 2	445..498
		RCC1	500..559	CDD:278826
		RCC1 4	563..627
		RCC1 5	628..680
		RCC1	628..676	CDD:278826
		RCC1 6	681..738
		Interaction with NEK6. /evidence=ECO:0000269\|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..991
ire1	NP_593384.1	Luminal_IRE1_like	82..440	CDD:276097
		STKc_IRE1	652..939	CDD:270884	83/309 (27%)
		S_TKc	658..938	CDD:214567	80/301 (27%)
		RNase_Ire1	942..1070	CDD:199217	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910