Protein Alignment NEK9 and nek8

DIOPT Version :10

• Sequence 1: NP_001316166.1
• Gene: NEK9 / 91754
• HGNCID: 18591
• Length: 991
• Species: Homo sapiens
• Sequence 2: NP_620776.2
• Gene: nek8 / 171094
• ZFINID: ZDB-GENE-020509-1
• Length: 697
• Species: Danio rerio
• Alignment Length: 723
• Identity: 264/723 - (36%)
• Similarity: 398/723 - (55%)
• Gaps: 75/723 - (10%)

Human    52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYN 116
            |..|:|:||||||...|.||..|.:||:.||:.:.:::..||..|.||..:|.||.|.|||.||.
Zfish     4 YEKIKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIEYYE 68

Human   117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLN 181
            :|:::..|:|.:||..||.|.|.|.::.:.|.:|:.::.:..||:.|:..:|...|||||:||.|
Zfish    69 NFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHFFVQILLALYHVHNKLILHRDLKTQN 133

Human   182 IFLTKANLI-KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELL 245
            |.|.|..:| |:||:|::|.|.|: |.|.|:||||.|:|||||:|..||.||||||:|||::||.
Zfish   134 ILLDKHQMIVKIGDFGISKILVSK-SKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELA 197

Human   246 TLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLD-----R 305
            :|||.|:|.|...|.:||:.|..|  ..|.:||.||.|::.:.|:.||.:||..:|::.     |
Zfish   198 SLKRAFEAANLPALVLKIMSGTFA--PISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIR 260

Human   306 PLL-------RKRRREMEEKVTLLNA-PTKRPR---SSTVTEAPIAVVTSR-------TSEVYVW 352
            |||       ..:.|.:|:.::.:.| |..||.   :||.|...::.:||.       .|.||.|
Zfish   261 PLLNLYTDIGNVKMRRIEKPLSNVQAGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLSSVYTW 325

Human   353 GGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP 417
            |.|.|||.:|.::.:  ...||..|.|....||....|.||.....|:   |:..........||
Zfish   326 GSGISTPLRLSMLNT--EVIQVSLGRTQKMGVTKSGRLITWEAPSVGS---GEPTLPGAVEQMQP 385

Human   418 KHVEK-LQGKA---IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG---VDKVAGPEVLEPMQLN 475
            :.:.: |:|::   |:.|||||.||.|:||.|.:..|||...||:|   .:.|..|:::|.:
Zfish   386 QFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEAL--- 447

Human   476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDV 540
              |...:.|||||.:||:.:|..:||:|||.|:            .|||||.:::.:..||:|.:
Zfish   448 --LGYELVQVSCGASHVLAVTNEREVFSWGRGD------------NGRLGLATQDSHNCPQQVSL 498

Human   541 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 605
            |.......|.||.|.:.:::...::||||.|.||||||:: :||.....::.:|.....|.|.:.
Zfish   499 PADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDK-VSGTEEPSSFCQVEEVHLFQLVQS 562

Human   606 --LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYK-KRLGINLLGGPLGGKQVIRV 667
              |:..||..|..|..|:.|:.|:|:..|||.|:.||||..:.: .|:...:.|  |.|  :...
Zfish   563 APLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSG--LQG--ITMA 623

Human   668 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHH---VPDLSCRG 729
            :|||.||:|...:..::.||.|..|||.    .:...|.|    |:|:.....|   |..::|..
Zfish   624 ACGDAFTLAIGAEGEVYTWGKGARGRLG----RKEEDSGI----PKPVQLDESHAFTVTSVACCH 680

Human   730 WHTILIVE 737
            .:|:|.|:
Zfish   681 GNTLLAVK 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..43
		STKc_Nek9	51..308	CDD:270860	118/261 (45%)
		ATS1	372..763	CDD:444065	123/379 (32%)
		RCC1 1	388..444		19/59 (32%)
		RCC1 2	445..498		19/55 (35%)
		RCC1 4	563..627		23/65 (35%)
		RCC1 5	628..680		19/52 (37%)
		RCC1 6	681..738		16/60 (27%)
		Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..991
nek8	NP_620776.2	STKc_Nek8	3..258	CDD:270859	116/256 (45%)
		ATS1	321..652	CDD:444065	122/361 (34%)
		RCC1 1	417..468		19/55 (35%)
		RCC1 2	469..520		19/62 (31%)
		RCC1 3	521..586		23/65 (35%)
		RCC1 4	587..636		19/52 (37%)
		RCC1 5	637..689		16/60 (27%)