DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK9 and nek8

DIOPT Version :9

Sequence 1:	NP_001316166.1	Gene:	NEK9 / 91754	HGNCID:	18591	Length:	991	Species:	Homo sapiens
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	723	Identity:	262/723 - (36%)
Similarity:	394/723 - (54%)	Gaps:	75/723 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYN 116
            |...:|:||||||...|.||..|.:||:.||:.:.:::..||..|.||..:|.||.|.|||.||.
Zfish     4 YEKTKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIEYYE 68

Human   117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLN 181
            :|:::..|:|.:||..||.|.|.|.::.:.|.:|:.::....||:.|:..:|...|||||:||.|
Zfish    69 NFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHSFVQILLALYHVHNKLILHRDLKTQN 133

Human   182 IFLTKANLI-KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELL 245
            |.|.|..:| |:||:|::|.|.|: |.|.|:||||.|:|||||:|..||.||||||:|||::||.
Zfish   134 ILLDKHQMIVKIGDFGISKILVSK-SKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELA 197

Human   246 TLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLD-----R 305
            :|||.|:|.|...|.:||:.|..|  ..|.:||.||.|::.:.|:.||.:||..:|::.     |
Zfish   198 SLKRAFEAANLPALVLKIMSGTFA--PISDRYSPELRQLILNMLNLDPSKRPQLNEIMAHAICIR 260

Human   306 PLL-------RKRRREMEEKVTLLNA-PTKRPR---SSTVTEAPIAVVTSRTS-------EVYVW 352
            |||       ..:.|.:|:.::.:.| |..||.   :||.|...::.:||...       .||.|
Zfish   261 PLLNLYTDIGNVKMRRIEKPLSNVQAGPHGRPGGWITSTRTRGGLSSLTSSKMMHPLPLFSVYTW 325

Human   353 GGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQP 417
            |.|.|||.:|.::.:  ...||..|.|....||....|.||.....|:   |:..........||
Zfish   326 GSGISTPLRLPMLNT--EVIQVSLGRTQKMGVTKSGRLITWEAPSVGS---GEPTLPGAVEQMQP 385

Human   418 KHVEK-LQGKA---IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG---VDKVAGPEVLEPMQLN 475
            :.:.: |:|::   |:.|||||.||.|:||.|.:..|||...||:|   .:.|..|:::|.:
Zfish   386 QFISRFLEGQSGVTIKSVSCGDLFTTCLTDRGIIMTFGSGSNGCLGHGNFNDVTQPKIVEAL--- 447

Human   476 FFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDV 540
              |...:.|||||.:||:.:|..:||:|||.|:            .|||||.:::.:..||:|.:
Zfish   448 --LGYELVQVSCGASHVLAVTNEREVFSWGRGD------------NGRLGLATQDSHNCPQQVSL 498

Human   541 PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 605
            |.......|.||.|.:.:::...::||||.|.||||||:: :||.....::.:|.....|.|.:.
Zfish   499 PADFEAQRVLCGVDCSMIMSTQHQILACGNNRFNKLGLDK-VSGTEEPSSFCQVEEVHLFQLVQS 562

Human   606 --LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYK-KRLGINLLGGPLGGKQVIRV 667
              |:..||..|..|..|:.|:.|:|:..|||.|:.||||..:.: .|:...:.|  |.|  :...
Zfish   563 APLNTEKIVYIDIGTAHSVAVTEKGQCFTFGSNQHGQLGCSHRRSSRVPYQVSG--LQG--ITMA 623

Human   668 SCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHH---VPDLSCRG 729
            :|||.||:|...:..::.||.|..|||..  .|...|.      |:|:.....|   |..::|..
Zfish   624 ACGDAFTLAIGAEGEVYTWGKGARGRLGR--KEEDFGI------PKPVQLDESHAFTVTSVACCH 680

Human   730 WHTILIVE 737
            .:|:|.|:
Zfish   681 GNTLLAVK 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..43
		STKc_Nek9	51..308	CDD:270860	117/261 (45%)
		S_TKc	52..308	CDD:214567	117/261 (45%)
		RCC1 1	388..444		19/59 (32%)
		RCC1	389..441	CDD:278826	17/55 (31%)
		RCC1	444..495	CDD:278826	18/53 (34%)
		RCC1 2	445..498		19/55 (35%)
		RCC1	500..559	CDD:278826	19/58 (33%)
		RCC1 4	563..627		23/65 (35%)
		RCC1 5	628..680		19/52 (37%)
		RCC1	628..676	CDD:278826	18/48 (38%)
		RCC1 6	681..738		16/60 (27%)
		Interaction with NEK6. /evidence=ECO:0000269\|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..991
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859	115/256 (45%)
		S_TKc	4..255	CDD:214567	115/253 (45%)
		ATS1	309..662	CDD:227511	127/387 (33%)
		RCC1 1	417..468		19/55 (35%)
		RCC1 2	469..520		19/62 (31%)
		RCC1 3	521..586		23/65 (35%)
		RCC1 4	587..636		19/52 (37%)
		RCC1 5	637..689		16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830