Protein Alignment NEK9 and nek9

DIOPT Version :10

• Sequence 1: NP_001316166.1
• Gene: NEK9 / 91754
• HGNCID: 18591
• Length: 991
• Species: Homo sapiens
• Sequence 2: XP_012823572.1
• Gene: nek9 / 100216232
• XenbaseID: XB-GENE-974101
• Length: 942
• Species: Xenopus tropicalis
• Alignment Length: 1007
• Identity: 692/1007 - (68%)
• Similarity: 796/1007 - (79%)
• Gaps: 87/1007 - (8%)

Human     1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGE 65
            ||.||.|:|||||||||||.....||                  .||||||||||||||.||:||
 Frog     1 MSALGRYDRHCDSINSDFGDSVRSCG------------------PEQEELHYIPIRVLGHGAYGE 47

Human    66 ATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEY 130
            ||||||||||||||||||.|.|||||||||||||||||:||||||||||||||:|:.||||||||
 Frog    48 ATLYRRTEDDSLVVWKEVGLARLSEKERRDALNEIVILSLLQHDNIIAYYNHFLDSNTLLIELEY 112

Human   131 CNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDY 195
            ||||||:|||:|||.:||:||||:||||||||||||||:||||||||||||||||||||||||||
 Frog   113 CNGGNLFDKIVRQKAQLFQEEMVLWYLFQIVSAVSCIHRAGILHRDIKTLNIFLTKANLIKLGDY 177

Human   196 GLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLC 260
            ||||:|:||||||||.|||.|||||||||||||:|||||||||||::|||||.||||||||||||
 Frog   178 GLAKQLSSEYSMAETCVGTLYYMSPELCQGVKYSFKSDIWAVGCVLYELLTLTRTFDATNPLNLC 242

Human   261 VKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAP 325
            ||||||..||.:|:|.||.:||::||:||:||||:||||||:|..|:|..|||:|||||::||..
 Frog   243 VKIVQGNWAMGLDNSVYSQDLIEVVHACLEQDPEKRPTADEILKMPILSWRRRDMEEKVSMLNRS 307

Human   326 TKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKEL 390
            .|:||:.|||||||||||||:||||||||||:|||||||.|.||.|||||||:.|||||||||||
 Frog   308 NKKPRTGTVTEAPIAVVTSRSSEVYVWGGGKTTPQKLDVFKGGCRARQVCAGDAHFAVVTVEKEL 372

Human   391 YTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYY 455
            |||||||||:||||||||||:|||||||||||||||:::|||||.|||||::||||||:||||||
 Frog   373 YTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQQVSCGSDFTVCISDEGQLYSFGSDYY 437

Human   456 GCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFF 520
            ||:||::.||.|||||:.::|||:.|||||||||:|::.|||:|.|||||||||
 Frog   438 GCLGVNQSAGAEVLEPLLVDFFLNEPVEQVSCGDSHIIALTRSKCVYSWGCGEY----------- 491

Human   521 TGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGI 585
             ||||||||:|.|:||||:|.:.|.||.|.||.||:||||.:||||||||||.|||||||..:||
 Frog   492 -GRLGLDSEDDVYSPQKVEVQRDLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGI 555

Human   586 INHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 650
            |||||:.|||||||.||||||||||||:|:||:||||||||||||||||.|||||||||:|:|.|
 Frog   556 INHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHL 620

Human   651 GINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPI 715
            ||||||||||||||||||||||||||||.|||||||||||||||||||.|||.||||||||||||
 Frog   621 GINLLGGPLGGKQVIRVSCGDEFTIAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPI 685

Human   716 FGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQE 780
            |||||||.|||||||||||||||||||||||||||||||||:.||.|     .|.|..||||::|
 Frog   686 FGSLHHVTDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTLAQSCS-----SGSGSREEDSERE 745

Human   781 SETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSA 845
            |.|.|||.|||||:||: ...|..:.||     |..|||||.|||:|||.||||||||:|:.:|.
 Frog   746 SLTSDPSRGFRGTIEAE-PETGPFNTTE-----NMESSSCPSWLRQELEEAEFIPMPDTPNFVSM 804

Human   846 AFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVE 910
            ..|::...:     ||.:|....| || ||..:                      ||.||:||.|
 Frog   805 ESSQNGTTS-----LQDVKETPNA-LE-KPSFQ----------------------ACTCSTLQEE 840

Human   911 VERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQ----VGMHSKGTQTAKEEMEM--- 968
            |.:||.:|....:||:.|.:||.::..::|:||.||:...|    |..|.:.....::::.:
 Frog   841 VRKLQDVVSTYRSEQELLCRENSRLALEVQELNAKLQSAMQMNQVVNKHGEAIHQLQKQLALYWK 905

Human   969 ----------DPKPDLDSDSWCLLGTDSCRPS 990
                      ..:.|.|::|||.|||::||.|
 Frog   906 SSPPSAGNAETSREDSDAESWCFLGTEACRSS 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..43		4/24 (17%)
		STKc_Nek9	51..308	CDD:270860	217/256 (85%)
		ATS1	372..763	CDD:444065	315/390 (81%)
		RCC1 1	388..444		47/55 (85%)
		RCC1 2	445..498		36/52 (69%)
		RCC1 4	563..627		53/63 (84%)
		RCC1 5	628..680		47/51 (92%)
		RCC1 6	681..738		53/56 (95%)
		Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501	744..903		70/158 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..795		25/42 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..853		9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..991		14/61 (23%)
nek9	XP_012823572.1	STKc_Nek9	33..290	CDD:270860	217/256 (85%)
		ATS1	354..730	CDD:444065	313/387 (81%)