DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEK9 and nek9

DIOPT Version :9

Sequence 1:	NP_001316166.1	Gene:	NEK9 / 91754	HGNCID:	18591	Length:	991	Species:	Homo sapiens
Sequence 2:	XP_012823572.1	Gene:	nek9 / 100216232	XenbaseID:	XB-GENE-974101	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	692/1007 - (68%)
Similarity:	796/1007 - (79%)	Gaps:	87/1007 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGE 65
            ||.||.|:|||||||||||.....||                  .||||||||||||||.||:||
Frog     1 MSALGRYDRHCDSINSDFGDSVRSCG------------------PEQEELHYIPIRVLGHGAYGE 47

Human    66 ATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEY 130
            ||||||||||||||||||.|.|||||||||||||||||:||||||||||||||:|:.||||||||
Frog    48 ATLYRRTEDDSLVVWKEVGLARLSEKERRDALNEIVILSLLQHDNIIAYYNHFLDSNTLLIELEY 112

Human   131 CNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDY 195
            ||||||:|||:|||.:||:||||:||||||||||||||:||||||||||||||||||||||||||
Frog   113 CNGGNLFDKIVRQKAQLFQEEMVLWYLFQIVSAVSCIHRAGILHRDIKTLNIFLTKANLIKLGDY 177

Human   196 GLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLC 260
            ||||:|:||||||||.|||.|||||||||||||:|||||||||||::|||||.||||||||||||
Frog   178 GLAKQLSSEYSMAETCVGTLYYMSPELCQGVKYSFKSDIWAVGCVLYELLTLTRTFDATNPLNLC 242

Human   261 VKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAP 325
            ||||||..||.:|:|.||.:||::||:||:||||:||||||:|..|:|..|||:|||||::||..
Frog   243 VKIVQGNWAMGLDNSVYSQDLIEVVHACLEQDPEKRPTADEILKMPILSWRRRDMEEKVSMLNRS 307

Human   326 TKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKEL 390
            .|:||:.|||||||||||||:||||||||||:|||||||.|.||.|||||||:.|||||||||||
Frog   308 NKKPRTGTVTEAPIAVVTSRSSEVYVWGGGKTTPQKLDVFKGGCRARQVCAGDAHFAVVTVEKEL 372

Human   391 YTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYY 455
            |||||||||:||||||||||:|||||||||||||||:::|||||.|||||::||||||:||||||
Frog   373 YTWVNMQGGSKLHGQLGHGDRASYRQPKHVEKLQGKSVQQVSCGSDFTVCISDEGQLYSFGSDYY 437

Human   456 GCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRGSLVSVHFF 520
            ||:||::.||.|||||:.::|||:.|||||||||:|::.|||:|.|||||||||
Frog   438 GCLGVNQSAGAEVLEPLLVDFFLNEPVEQVSCGDSHIIALTRSKCVYSWGCGEY----------- 491

Human   521 TGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGI 585
             ||||||||:|.|:||||:|.:.|.||.|.||.||:||||.:||||||||||.|||||||..:||
Frog   492 -GRLGLDSEDDVYSPQKVEVQRDLCIVNVCCGSDGSFLLTLTGKVLACGLNEHNKLGLNQYTAGI 555

Human   586 INHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRL 650
            |||||:.|||||||.||||||||||||:|:||:||||||||||||||||.|||||||||:|:|.|
Frog   556 INHEAFQEVPYTTSLTLAKQLSFYKIRSISPGRTHTAAIDERGRLLTFGSNKCGQLGVGDYRKHL 620

Human   651 GINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPI 715
            ||||||||||||||||||||||||||||.|||||||||||||||||||.|||.||||||||||||
Frog   621 GINLLGGPLGGKQVIRVSCGDEFTIAATADNHIFAWGNGGNGRLAMTPNERPQGSDICTSWPRPI 685

Human   716 FGSLHHVPDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQE 780
            |||||||.|||||||||||||||||||||||||||||||||:.||.|     .|.|..||||::|
Frog   686 FGSLHHVTDLSCRGWHTILIVEKVLNSKTIRSNSSGLSIGTLAQSCS-----SGSGSREEDSERE 745

Human   781 SETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSA 845
            |.|.|||.|||||:||: ...|..:.||     |..|||||.|||:|||.||||||||:|:.:|.
Frog   746 SLTSDPSRGFRGTIEAE-PETGPFNTTE-----NMESSSCPSWLRQELEEAEFIPMPDTPNFVSM 804

Human   846 AFSESEKDTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVE 910
            ..|::...:     ||.:|....| || ||..:                      ||.||:||.|
Frog   805 ESSQNGTTS-----LQDVKETPNA-LE-KPSFQ----------------------ACTCSTLQEE 840

Human   911 VERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQ----VGMHSKGTQTAKEEMEM--- 968
            |.:||.:|....:||:.|.:||.::..::|:||.||:...|    |..|.:.....::::.:
Frog   841 VRKLQDVVSTYRSEQELLCRENSRLALEVQELNAKLQSAMQMNQVVNKHGEAIHQLQKQLALYWK 905

Human   969 ----------DPKPDLDSDSWCLLGTDSCRPS 990
                      ..:.|.|::|||.|||::||.|
Frog   906 SSPPSAGNAETSREDSDAESWCFLGTEACRSS 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..43		4/24 (17%)
		STKc_Nek9	51..308	CDD:270860	217/256 (85%)
		S_TKc	52..308	CDD:214567	216/255 (85%)
		RCC1 1	388..444		47/55 (85%)
		RCC1	389..441	CDD:278826	45/51 (88%)
		RCC1	444..495	CDD:278826	35/50 (70%)
		RCC1 2	445..498		36/52 (69%)
		RCC1	500..559	CDD:278826	33/58 (57%)
		RCC1 4	563..627		53/63 (84%)
		RCC1 5	628..680		47/51 (92%)
		RCC1	628..676	CDD:278826	43/47 (91%)
		RCC1 6	681..738		53/56 (95%)
		Interaction with NEK6. /evidence=ECO:0000269\|PubMed:19001501	744..903		70/158 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..795		25/42 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..853		9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..991		14/61 (23%)
nek9	XP_012823572.1	STKc_Nek9	33..290	CDD:270860	217/256 (85%)
nek9	XP_012823572.1	ATS1	370..708	CDD:227511	279/349 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I4983
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13222
Inparanoid	1	1.050	1372	1.000	Inparanoid score	I1723
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0013782
OrthoInspector	1	1.000	-	-		oto157224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11310
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980