DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K13 and wnd

DIOPT Version :9

Sequence 1:	NP_001229243.1	Gene:	MAP3K13 / 9175	HGNCID:	6852	Length:	966	Species:	Homo sapiens
Sequence 2:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	1053	Identity:	378/1053 - (35%)
Similarity:	509/1053 - (48%)	Gaps:	238/1053 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    17 PFSE--SKTFNGL-------QDELTAMGNH--PSPKLLEDQQEKGMVRTELI----ESVHSPVTT 66
            |||:  ||:.:.|       |.:|.....|  .||.|..||.:.  :|..:.    |..|..:..
  Fly     3 PFSDSLSKSRDDLVTAASRQQQQLHGRRRHHGSSPNLSLDQTDN--LRRSMACLQDEFGHLGIAA 65

Human    67 TVLTSVSED----SRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGS 127
            |.|...|.|    .|.|..|:..::.:.....|...:...:.....:..|..|..|
  Fly    66 TDLPFKSSDLDSPPRLQHHNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPI--------- 121

Human   128 GGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEV 192
             |::.||.||::||.:.|||....:.|.|:.:.|::|||.|:||:|||||||||||.|:.:.|.|
  Fly   122 -GWMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETV 185

Human   193 AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 257
            |:|||:|..||||||||||.|.|||.|||||||:|.:|||||:|.:|.|..:|:..:.:.|..||
  Fly   186 AVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLV 250

Human   258 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAP 322
            .||..||.||.|||.||||||||||||:|::..:.|||||||||:|.::.|||||||||||||||
  Fly   251 SWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAP 315

Human   323 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 387
            |||||||.||||||||:||||||:||.|||||||||||||||||:|||.|.||||||:|||:|:|
  Fly   316 EVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVK 380

Human   388 QTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDE 452
            ..|:|||||||||||.|.|||||..::|...::.||::|..|:|||:.|.::|...||.||:.::
  Fly   381 LCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQ 445

Human   453 ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGT-YK 516
            :||:||..|.|||.|||..||.||::.|.|:.|||..|.||:.:|||:.:|    |:|.||: ||
  Fly   446 DLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAER----ERKLPGSGYK 506

Human   517 RHPVRPIIHPNAMEKLM--KRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTAS------------ 567
              |.|..  .|.:.|:.  :|:..|..:.:|       :....|..|..|.:.
  Fly   507 --PNRRF--GNTIRKMQHYRRRLNPAPAAIQ-------QQSTTPDPETTPESPVKCMLYAQLDSN 560

Human   568 -----------PLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYL 621
                       |.||......:.:|..:    |||| |:.||   |.|..|..|.::
  Fly   561 CQPKSYLANIIPSSGLGAPMPNKNKKVF----RHRR-NASGS---FGAPPKYSPTRD-------- 609

Human   622 HQAQSQYPSLHHHNSLQQQYQQPPP------AMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR 680
                             ::||..|.      ...|:....:::...||:..|...|    :..:.
  Fly   610 -----------------RRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPR----SQPID 653

Human   681 SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADA----------YDPCLQC 735
            .|:.||.|..|.......|:.|.|.....|:....|...|  .|.::.          .|.|  .
  Fly   654 VPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNP--ACPSNGNSLSTSELTYQDAC--S 714

Human   736 RPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLE---------------NAQSSEKTEENEFSGCR 785
            .|:|.....:.|.|.:    |:::..:.|..||               :.||:..:..|..:|..
  Fly   715 SPDQLIDDVMNSNERL----DMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNG 775

Human   786 SESSLGTSHLGTPPAL--------PRKTRPLQKSGD-----------------DSSEEEEGE-VD 824
            ..|.|.....|..|.|        .|:..||   ||                 ||..:|||| .|
  Fly   776 GASPLELRESGNSPCLSRCSSTHSKRRKHPL---GDNPNGSSIGNANGESHEQDSWSDEEGETTD 837

Human   825 SEVEFPRR----------QRPHRCISSCQSYSTFSSENFS--------VSDGEEGNTSDHSNSPD 871
            .:....||          .||.|      ||....|:..:        ||| ||.|||::|:||.
  Fly   838 YKYALRRRSIGRQPIARGMRPRR------SYKAPLSQKIAIHKRNVVIVSD-EEENTSEYSHSPS 895

Human   872 ELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPM 936
            .....||                      |::| ::|.:      |||.:    ......|..|
  Fly   896 SQHSTLE----------------------SNTD-IADMK------KTQAT----STSSNSYSEP- 926

Human   937 QFEESDCDSSDGE 949
              |:...||||.|
  Fly   927 --EDDSSDSSDEE 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K13	NP_001229243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..114		2/23 (9%)
		STYKc	168..402	CDD:214568	168/233 (72%)
		STKc_MAP3K12_13	174..410	CDD:270961	170/235 (72%)
		Leucine-zipper 1	433..454		7/20 (35%)
		Leucine-zipper 2	486..507		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..599		16/87 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..655		4/49 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..834		29/140 (21%)
		Acidic. /evidence=ECO:0000305	815..828		6/13 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..908		16/69 (23%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	171/238 (72%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	170/235 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I973
eggNOG	1	0.900	-	-		E1_KOG4721
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1339
Isobase	1	0.950	-	0	Normalized mean entropy	S2281
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm40729
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2490
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.700