DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL1RL1 and il1rl1

DIOPT Version :9

Sequence 1:	NP_057316.3	Gene:	IL1RL1 / 9173	HGNCID:	5998	Length:	556	Species:	Homo sapiens
Sequence 2:	XP_021334743.1	Gene:	il1rl1 / 407649	ZFINID:	ZDB-GENE-060621-4	Length:	471	Species:	Danio rerio

Alignment Length:	501	Identity:	154/501 - (30%)
Similarity:	237/501 - (47%)	Gaps:	52/501 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    55 KSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMY 119
            :.|.|:|..||......|..|...:.|:|.|.      |:.|....:.:.:  ::|..|.:....
Zfish     4 EQIGTEESQRVHYHKSSLYILNLTLNDTGKYI------TYWRDAEGSCSEF--ETDIVVHENFSR 60

Human   120 STVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFI 184
            ..:.|..:||:|.||...  |......|:|:...:...    .||.|.|.|:..|..|.|||...
Zfish    61 DLLYGKTENSEIICPICK--NQPGSFIWYKDFTLIPNQ----SKSSLRIRNISKESQGIYTCVCT 119

Human   185 HNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAV 249
            .:.:|..|:.:.:|...:| |:...:.|....|..|.|....||....|.||..||.......:|
Zfish   120 WDHHGIKYNTSGSRELVIK-EKTVRIPPQFRLPINNSIVNTNIGAEMLLNCSVLFGTVVCDFCSV 183

Human   250 LWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRH 314
            .|:.||.|        :.:.:|..:.:|........:|.|..|.|.||..::.|.|::.:|:...
Zfish   184 HWEKNGIK--------VNKMKGYEEKYSKNGGFAHSLLNITAVSELDLQSKFHCAAMDEYGVIYV 240

Human   315 TVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVII---LKMFWIEATLLWRDI-AKPYKTRNDGK 375
            .|.|.|:.        .::.|..||:.:..||::.   ::.|.::..||.|.: .|.|:| .|||
Zfish   241 LVTLKREP--------SVLTVVLVFIFIFTVLLLFAGTVRWFALDLVLLARKLFIKLYRT-EDGK 296

Human   376 LYDAYVVYPRNYKSSTDGAS--RVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNI 438
            ||||||:|.|   |..||.:  .|..||:..|..|||:.|||.|.|:|||.|||||....::|.|
Zfish   297 LYDAYVIYQR---SGLDGETGHAVSEFVNGALLPVLESSCGYKLFIHGRDDLPGEDSANLIQTKI 358

Human   439 RKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHL 503
            :.|||.:.||:.:.......||:.:..||.||:|.:..||:|::..:.:...|..     .||||
Zfish   359 QLSRRLLIILSAEGVGGSAEAYDLQAGLHQALVQGETPVIIIQLGLMQDYSHLPL-----GLQHL 418

Human   504 MKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPR--KASS 547
            ::.:..:.||:    .:.||||:|||.|||:||..|...|  :||:
Zfish   419 LRKRSALLWRD----GEASLNSRFWKRVRYRMPAASATIRGSRASN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1RL1	NP_057316.3	Ig	16..104	CDD:299845	12/48 (25%)
		IG_like	21..104	CDD:214653	12/48 (25%)
		Ig2_IL1R_like	118..204	CDD:143234	22/85 (26%)
		IG_like	120..197	CDD:214653	21/76 (28%)
		Flexible linker	198..211		3/12 (25%)
		TIR	380..535	CDD:279864	61/156 (39%)
il1rl1	XP_021334743.1	PHA02785	<19..231	CDD:333475	58/234 (25%)
		Ig	67..139	CDD:325142	22/78 (28%)
		TIR	298..447	CDD:214587	64/160 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I33898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1109920at2759
OrthoFinder	1	1.000	-	-		FOG0013340
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	6	6.420