DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACY3 and SCAP

DIOPT Version :10

Sequence 1:XP_016874038.1 Gene:ACY3 / 91703 HGNCID:24104 Length:326 Species:Homo sapiens
Sequence 2:NP_788277.1 Gene:SCAP / 35529 FlyBaseID:FBgn0033052 Length:1276 Species:Drosophila melanogaster


Alignment Length:414 Identity:84/414 - (20%)
Similarity:127/414 - (30%) Gaps:132/414 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     7 PREPLRRVAVTGGTHGNEMSGV------YLARHWLHAPAELQRASFSAVPVLANP----AATSGC 61
            |..|....|...|..|...:|:      :..:|.|.         .|:.|..|:.    |....|
  Fly    34 PPGPAPSSAGVAGAAGASSTGLPASVSHFYYKHGLF---------LSSYPTCASSIAFMAILLSC 89

Human    62 RRYVDHDLNRTFTSSFLKP---GSGQLS------SRPTPDDPY--------------EVTRAREL 103
            ...::..|..|..:..:.|   |||.||      |..||.:|:              ..|..|..
  Fly    90 YPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSP 154

Human   104 NQLLGPKASGQAFDFVLDLHNTTANM----GTCLI---AKSSHEVFAM----------------- 144
            ..||....|..||.:|..:...|:.:    |..|:   ....||||.:                 
  Fly   155 PPLLPWAQSSPAFFYVQQITLRTSVLPWTEGMQLMDAFRAPLHEVFKLLEIVRNHQSSENKRTLE 219

Human   145 HLCRHL---------QLQ--YPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADI 198
            |.|.|:         ||.  :||..|                        |.|.|.......:..
  Fly   220 HNCLHVDNVKRGTHGQLDQIFPEYGC------------------------LLLSPANLWTQNSQN 260

Human   199 FSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPV---GVVDFP---RTEAGHLAGTVHPQLQD- 256
            |:|...::.|:..:..|  |.:...|.||....|:   |...:|   |:.....|.|:..:..| 
  Fly   261 FTRDTNILNTIFQYHNL--QKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHNDM 323

Human   257 -----------RDFQPL--------QPGAPIFQMFSGEDLLYEGESTVYPV-FINEAAYYEKGVA 301
                       |.:.||        :|....:..:.||..::  |...|.| |:...||....|.
  Fly   324 EYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMW--ELVPYTVAFMLVFAYVYFSVR 386

Human   302 FVQTEKFTFTVPAMPALTPAPSPA 325
            .:...:..|.:.....:|.|.|.|
  Fly   387 KIDVFRSRFLLALCSVITTAGSLA 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACY3XP_016874038.1 Peptidase_M14_like 11..307 CDD:472171 77/390 (20%)
SCAPNP_788277.1 Sterol-sensing 390..543 CDD:463544 5/21 (24%)
WD40 878..1185 CDD:475233
WD40 repeat 887..942 CDD:293791
WD40 repeat 945..983 CDD:293791
WD40 repeat 989..1070 CDD:293791
WD40 repeat 1079..1114 CDD:293791
WD40 repeat 1120..1157 CDD:293791
WD40 repeat 1162..1196 CDD:293791
WD40 repeat 1201..1233 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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