Protein Alignment SCAF11 and CG2926

DIOPT Version :9

• Sequence 1: XP_011537286.1
• Gene: SCAF11 / 9169
• HGNCID: 10784
• Length: 1479
• Species: Homo sapiens
• Sequence 2: NP_649554.1
• Gene: CG2926 / 40676
• FlyBaseID: FBgn0037344
• Length: 2296
• Species: Drosophila melanogaster
• Alignment Length: 2289
• Identity: 417/2289 - (18%)
• Similarity: 673/2289 - (29%)
• Gaps: 983/2289 - (42%)

Human    30 KKYEDMEGEE----------------NGDNTISTGLLYSE-ADRCPICLNCLLEKEVGFPESCNH 77
            ||.|..:.||                :.|:..|:.:..:: .::|||||....::|:|.|.:|.|
  Fly   111 KKVESSDEEEPERTPNAVGRIQPMPADPDDGFSSDISSNDLLEKCPICLLTFRQQEIGTPATCEH 175

Human    78 VFCMTCILKWAETLASCPIDRKPFQAVFKFSALEGYVKVQVKKQLRETKDKKN-----ENSFEKQ 137
            :||..||..|:..:.:|||||..|..:.   ..:.|...:|.:::|....|.|     ::..:..
  Fly   176 IFCAACIDAWSRNVQTCPIDRIEFDRII---VRDSYASRRVVREVRLDLSKSNTELVVDDEADTA 237

Human   138 VSCHENSKSCIRRKAIVREDLLSAKVCDL--------------------KWIHRN---------- 172
            ....|...:|...::..|||::  .:||.                    .|...|
  Fly   238 ALSEEEVTNCEICESPDREDVM--LLCDSCNQGYHMDCLDPPLYEIPAGSWYCDNCIDSDDEDDN 300

Human   173 ----------SLYSETGG----------------------KKNAAIKINKPQR------------ 193
                      .||.:..|                      ::|..|:....:|
  Fly   301 EQLELADDLDQLYEDIRGMGLPETRLRVREVQEPPRILRTRQNERIRAAVLRRTRSGATSAEDST 365

Human   194 -----------SNWSTNQCFRNFFSNMFSSVSHSGESSFTYRAYCTEF----------IEASEIS 237
                       :..:|....|...|.....|.........||.|..|:          ::.|:
  Fly   366 LTRTRTRTTTTTTTTTTTTRRTTTSTKKRPVQRRRRRRTRYRTYVVEYDLNNFDEKFALKTSK-- 428

Human   238 ALIRQKRHEL-----------------------------------------------------EL 249
            .:||::|...                                                     :|
  Fly   429 KVIRRRRRRRRRGVATASSEGPGRRLSASKRLAEQMGVKSEGFQSSHLSGGTASSFSLFGNANDL 493

Human   250 SWFPDTLP---------GIG--------RIGFI------------------PWNVETE--VLPLI 277
            .:|.|:.|         |:|        |||.|                  |....|.  ...::
  Fly   494 EYFSDSEPDAVSQISSAGLGSTAVQTSVRIGSIGAPRIRKALLQGKARIAAPPTAPTSAPAADIL 558

Human   278 SSVL--------------------------PRTIFPTST-ISFEHFGTSCKGYALAHT---QEG- 311
            ||:|                          |:...||:| ......|||.....|...   |:|
  Fly   559 SSILDLQDRWHDASRNLGEVHIRADGTLNIPQRPAPTATEAPLPKAGTSKTEKHLTQAPLYQQGG 623

Human   312 ---------------EEKKQTSGTSNTRG---------SRRKPAMTTPTRRSTRNTRAETASQSQ 352
                           ....:.||.::.||         |......::....|:|:...|...|..
  Fly   624 GGPNYNRGGGAGSSDSYNNRYSGNTSYRGGGGGGAGGSSGGSGVPSSSGEASSRHLTGEGDGQGG 688

Human   353 RSPISDN-SGCDAPGNSNPSLSVPSSAESEKQTR-QAPKRKSVR---------RGRKPPLLKKKL 406
            ....:.| |...:..|:|.|..:|........|| |.|::::|.         .|..||
  Fly   689 GGFGNQNFSSSGSNNNTNMSSFIPFHLRFNTPTRQQQPRQQNVLPANQPTPPFPGSAPP------ 747

Human   407 RSSVAAPEKSSSND----------SVDEETAESDTSPVLEKEHQPDVDSSNI------------- 448
                .||..||||:          .::...|.....||:.....|.:..:::
  Fly   748 ----PAPVASSSNNFSGQTPMFAAPLNHHPAPVMGMPVVLSIPPPPMPPASLPWNSPLFKITPLQ 808

Human   449 -CTVQTHVENQSANCLKSCNEQIEESEKH-TAN------------YDTEERVGSSSSESCAQ--- 496
             ...:::..||:.:.....|..|...|.. .||            .|..::.....:|...|
  Fly   809 QAPAKSNDGNQNDDVDNCPNFSIYSQESQAVANASAMPSGVPHGPADASDKDDDDMNEDLVQLDD 873

Human   497 -----DLPVLVGEEGEVKKLENTGIEANVLCLESEISENILEKGGDPL-EKQDQISGLSQSEVKT 555
                 |:|:.:|.|.|                  .:.|.:.:...|.| |.::......:.|:..
  Fly   874 DDEDTDIPLPLGPEPE------------------PVPEKVPKSSDDDLYEPENPTEEPEEPEMFE 920

Human   556 DVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEE--------KITESSLV------ 606
            :.|.. :|.:     .|||..::|       .:.||::...||        :.|.|.||
  Fly   921 ESCDA-VPTE-----KSESSDHEP-------SNSNVQAAAPEENDAEEARTRSTPSPLVKEDRAA 972

Human   607 ---------EITEHKDFTLKTEEL-IESPK------LESSEGEIIQTVDRQSVKSPEVQLLGHVE 655
                     |:.:..|:    ||| |:.||      |..:|.::  :..|...|.|.
  Fly   973 DRDRAKGVLELYDDSDW----EELDIDKPKEFEKALLTETEAQV--SPKRAPSKRPP-------- 1023

Human   656 TEDVEIIATCDTFGNEDFNNI-QDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTEL-PKTHI 718
                   :..||....|.|.. .:.|.:......|:   ||:|.|:.|:.|.|..:... |||..
  Fly  1024 -------SKKDTSLERDVNESGSEHEQDRSYTPCLD---EKNLAEEEEAGTTHQNNVSTSPKTRS 1078

Human   719 EQIQKHFSEDNNEMIPMECDSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMP----SSDLA 779
            .::                     ..:|.|.|.:|..|::..:|.:    :||..|    |...|
  Fly  1079 SKV---------------------SGDEDEPEKAVGTDIQSEDELN----NENESPRRSRSRGTA 1118

Human   780 DEKVETVSQPSESPK-DTIDKT-KKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKE 842
            :.|.:.....|:..| :|..|. |:.:.|..|........||..|:.....:.:|.|||  ..|.
  Fly  1119 NNKKDKSKSRSKRNKGETFKKVGKRQKDRNYRGDKSEPDRSPRPDSRSLTPKMRSKSPR--VSKS 1181

Human   843 SRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRET---- 903
            ..:|:|.|.....::...:|||:||.:...|.||.|:|:|..|..:|...||.|.|.:|.:
  Fly  1182 ISRSRSGSRSRCKSKSFSRSRSRSPSRSRNRRRRNSRSKSYSRSHSRSRSRSNSHSRQRFSFRGR 1246

Human   904 ---------------------------------------------------------------SR 905
                                                                           .|
  Fly  1247 DHQRGFFRGRGGLRLNYRNQQFHNRPFQHYGQNYHQNQNYHHQHNQHQNYFPPNQHGQHQQYFQR 1311

Human   906 ENKRSQPR--VKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSS 968
            ..:|..||  |::.....:.::|:::|.. ||..|..|.|..|:  .|||.|||.||....|..|
  Fly  1312 PKRRELPRYDVRNVVGTSRHQTQAKDRYG-RDAMRSHRSRSGRR--NSRSFSRSVSRDSRVSLRS 1373

Human   969 SFGRIDRDSYS------------PRWKGRWANDGWRCPRGNDRYRKND---PEKQNENTRKEKND 1018
            ..|...|.|:|            |...||     .|....|.||.::.   |..:||........
  Fly  1374 RSGSPKRRSFSMSPTPPPGTSPPPHKHGR-----GRQTSTNRRYARSPSPAPSPRNERATSPVQS 1433

Human  1019 IH---LDADDPN--SADKHRND----CPNWITEKINSGPDPRTRNP----EKLKESHWEENRNEN 1070
            :|   ..:..||  :.|.:|:.    .|::......|....|:::|    :|.|:...::.|.:.
  Fly  1434 VHSRRSRSHTPNRINGDGNRSSLYMGSPHYTPRISRSRSRSRSKSPKDMHKKKKKKSDKKKRRKR 1498

Human  1071 SGNS----------------------------------------W------------------NK 1077
            :|:|                                        |                  :|
  Fly  1499 TGSSSPTTAARMRRISRQRDPFEDADDFLAPQRKRKKAGITTGQWSPSPSPGRCDFLHDSALQDK 1563

Human  1078 NFGSGWVSNRGRGRG----NRGRGTYRSSFAYKDQN------------------ENRWQNRKPL- 1119
            |  |.|....|..:|    |.|..|.:.:...:|::                  :.|.|..:||
  Fly  1564 N--SSWTPPLGTPKGGHYNNDGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKKRKRRTQTPEPLP 1626

Human  1120 ------SGN-----------SNSSGSESFKFVEQQS-----------YKRKSEQEFSFDTPADRS 1156
                  |||           ||::.:.:....:|||           ...:.....|..:.|..|
  Fly  1627 SKEVFASGNNILVSVSFNKESNTNNASATLSSQQQSVVTIPPGREDLLSNRMTSMTSMASMASNS 1691

Human  1157 GWTSASSWAVRKTL--------------------------PADV----------QNYYSRR---- 1181
            ...||.. ||:||.                          ||||          :...|||
  Fly  1692 NICSAVG-AVKKTKRKRKKLEAKPVAIIDLERSPFQVHQEPADVIVLTDSEDATEPLSSRRERER 1755

Human  1182 ----------GRNSSGPQSGWMKQEEETSGQDSSLK----------------------------- 1207
                      |:....||.|.:....|||.::.:..
  Fly  1756 DRDHELMRENGQREKTPQVGSLDAIMETSYENMTQSTGPKTPPEPPLVKFNLPTKKIQHKVRNNP 1820

Human  1208 -----------------------DQTNQ----QVDGSQL------------------PIN----- 1222
                                   :||.|    ..||.|.                  |..
  Fly  1821 LHEDVDDINSADELEASCSMAPAEQTPQHGHASHDGGQKIGPNTPPESGPCSPDAYDPFEPTKSP 1885

Human  1223 -------MMQPQMNVMQQQMN--------------------------------AQHQPMNIFPYP 1248
                   .:.|..|:.||.::                                ||...:|    |
  Fly  1886 SLSPRSPTLTPSQNLDQQTVSMPASGAIGPGSGDKGESDGAHVTGSNASTNTQAQGNALN----P 1946

Human  1249 VGVHAPLMNIQRNPFNIHPQ-------------LPLHLHTGVP---------------------- 1278
            |.:...|||......:|..:             |.|.|..|..
  Fly  1947 VDLVMALMNKPNQSGSIQQESEVSSAQYISSSSLSLSLGVGSSTGGGGGGAGGGDNHDKTADGKT 2011

Human  1279 -------LMQVATPTSVSQGLPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLP 1336
                   |:..::..|.||.:|....|.|||            |:|..:|.:.....:.|:.|..
  Fly  2012 ITVLSNVLLTSSSVVSSSQHIPSISSPTPPS------------KKLTPLPKAGGSVASSSSGVGN 2064

Human  1337 APTAAPGNTGMVQGPSSGNTSSSSHS------------------------------KASNAA--- 1368
            .||.:.|..|...|...||...||::                              :||..|
  Fly  2065 IPTTSSGIGGTRNGSGLGNAGGSSNALDDSFSMEIESPYSPGSADYEDLFEPPIPLEASRRAKGG 2129

Human  1369 -----VKLAE---------------SKVSVAVEASADSSKTDKKLQI------------------ 1395
                 |::.:               |:.:.||...::.:|.|:|.::
  Fly  2130 ATGGKVEIFDNLFGSSSPISNIRMTSRYNTAVGKKSNRTKADRKSKVKGARNPDFYDDVPNSATD 2194

Human  1396 -------------QEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVAN 1447
                         ||:..:||||.:||::..|.|||::||:|:|:||.|:|||:|||:|..|:.|
  Fly  2195 LQNKDRLLRKLNRQERVVEEVKLVLKPYFNKKAITKDDYKDIMRRAVPKICHSRSGEINPHKIKN 2259

Human  1448 LVKAYVDKYKYSRK 1461
            |:.|||.|::...|
  Fly  2260 LIDAYVRKFRAKHK 2273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAF11	XP_011537286.1	PHA02929	<1..106	CDD:222944	28/92 (30%)
		zf-RING_2	55..98	CDD:290367	18/42 (43%)
		Relaxase	<744..936	CDD:304452	56/266 (21%)
CG2926	NP_649554.1	zf-RING_2	155..196	CDD:290367	18/40 (45%)
		PHD_PHRF1	246..291	CDD:277011	7/46 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0825
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.790