Protein Alignment SCAF11 and CG2926

DIOPT Version :10

• Sequence 1: XP_005269287.3
• Gene: SCAF11 / 9169
• HGNCID: 10784
• Length: 1527
• Species: Homo sapiens
• Sequence 2: NP_649554.1
• Gene: CG2926 / 40676
• FlyBaseID: FBgn0037344
• Length: 2296
• Species: Drosophila melanogaster
• Alignment Length: 2399
• Identity: 435/2399 - (18%)
• Similarity: 710/2399 - (29%)
• Gaps: 1016/2399 - (42%)

Human     1 MQEGGSEAVGRRG------RGKVGRKLI------PGRRQGGWRAQHARTERGQATGKRVSARLKA 53
            |.:..|:||...|      ||:..|::|      ........:.:..|.....||..|.|.|.:.
  Fly     1 MSDRDSDAVSDAGPRLSQQRGQRNRRIIMRIEFKDSEDSASDQDRDDRPSCSAATRLRRSTRRQE 65

Human    54 TGTW---ETLFQREMKK-------KTVCTLNMGD-----------KKYEDMEGEE---------- 87
            ..:.   :::.::..:|       ::.|:.:..|           ||.|..:.||
  Fly    66 VASHSDSDSVPRKSTRKLRNRYGPRSDCSSSGSDIDQLPTRTRKRKKVESSDEEEPERTPNAVGR 130

Human    88 ------NGDNTISTGLLYSE-ADRCPICLNCLLEKEVGFPESCNHVFCMTCILKWAETLASCPID 145
                  :.|:..|:.:..:: .::|||||....::|:|.|.:|.|:||..||..|:..:.:||||
  Fly   131 IQPMPADPDDGFSSDISSNDLLEKCPICLLTFRQQEIGTPATCEHIFCAACIDAWSRNVQTCPID 195

Human   146 RKPFQAVFKFSALEGYVKVQVKKQLRETKDKKN-----ENSFEKQVSCHENSKSCIRRKAIVRED 205
            |..|..:.   ..:.|...:|.:::|....|.|     ::..:......|...:|...::..|||
  Fly   196 RIEFDRII---VRDSYASRRVVREVRLDLSKSNTELVVDDEADTAALSEEEVTNCEICESPDRED 257

Human   206 LLSAKVCDL--------------------KWIHRN--------------------SLYSETGG-- 228
            ::  .:||.                    .|...|                    .||.:..|
  Fly   258 VM--LLCDSCNQGYHMDCLDPPLYEIPAGSWYCDNCIDSDDEDDNEQLELADDLDQLYEDIRGMG 320

Human   229 --------------------KKNAAIKINKPQR-----------------------SNWSTNQCF 250
                                ::|..|:....:|                       :..:|....
  Fly   321 LPETRLRVREVQEPPRILRTRQNERIRAAVLRRTRSGATSAEDSTLTRTRTRTTTTTTTTTTTTR 385

Human   251 RNFFSNMFSSVSHSGESSFTYRAYCTEF----------IEASEISALIRQKRHEL---------- 295
            |...|.....|.........||.|..|:          ::.|:  .:||::|...
  Fly   386 RTTTSTKKRPVQRRRRRRTRYRTYVVEYDLNNFDEKFALKTSK--KVIRRRRRRRRRGVATASSE 448

Human   296 -------------------------------------------ELSWFPDTLP---------GIG 308
                                                       :|.:|.|:.|         |:|
  Fly   449 GPGRRLSASKRLAEQMGVKSEGFQSSHLSGGTASSFSLFGNANDLEYFSDSEPDAVSQISSAGLG 513

Human   309 --------RIGFI------------------PWNVETE--VLPLISSVL---------------- 329
                    |||.|                  |....|.  ...::||:|
  Fly   514 STAVQTSVRIGSIGAPRIRKALLQGKARIAAPPTAPTSAPAADILSSILDLQDRWHDASRNLGEV 578

Human   330 ----------PRTIFPTST-ISFEHFGTSCKGYALAHT---QEG----------------EEKKQ 364
                      |:...||:| ......|||.....|...   |:|                ....:
  Fly   579 HIRADGTLNIPQRPAPTATEAPLPKAGTSKTEKHLTQAPLYQQGGGGPNYNRGGGAGSSDSYNNR 643

Human   365 TSGTSNTRG---------SRRKPAMTTPTRRSTRNTRAETASQSQRSPISDN-SGCDAPGNSNPS 419
            .||.::.||         |......::....|:|:...|...|......:.| |...:..|:|.|
  Fly   644 YSGNTSYRGGGGGGAGGSSGGSGVPSSSGEASSRHLTGEGDGQGGGGFGNQNFSSSGSNNNTNMS 708

Human   420 LSVPSSAESEKQTR-QAPKRKSVR---------RGRKPPLLKKKLRSSVAAPEKSSSND------ 468
            ..:|........|| |.|::::|.         .|..||          .||..||||:
  Fly   709 SFIPFHLRFNTPTRQQQPRQQNVLPANQPTPPFPGSAPP----------PAPVASSSNNFSGQTP 763

Human   469 ----SVDEETAESDTSPVLEKEHQPDVDSSNI--------------CTVQTHVENQSANCLKSCN 515
                .::...|.....||:.....|.:..:::              ...:::..||:.:.....|
  Fly   764 MFAAPLNHHPAPVMGMPVVLSIPPPPMPPASLPWNSPLFKITPLQQAPAKSNDGNQNDDVDNCPN 828

Human   516 EQIEESEKH-TAN------------YDTEERVGSSSSESCAQ--------DLPVLVGEEGEVKKL 559
            ..|...|.. .||            .|..::.....:|...|        |:|:.:|.|.|
  Fly   829 FSIYSQESQAVANASAMPSGVPHGPADASDKDDDDMNEDLVQLDDDDEDTDIPLPLGPEPE---- 889

Human   560 ENTGIEANVLCLESEISENILEKGGDPL-EKQDQISGLSQSEVKTDVCTVHLPNDFPTCLTSESK 623
                          .:.|.:.:...|.| |.::......:.|:..:.|.. :|.:     .|||.
  Fly   890 --------------PVPEKVPKSSDDDLYEPENPTEEPEEPEMFEESCDA-VPTE-----KSESS 934

Human   624 VYQPVSCPLSDLSENVESVVNEE--------KITESSLV---------------EITEHKDFTLK 665
            .::|       .:.||::...||        :.|.|.||               |:.:..|:
  Fly   935 DHEP-------SNSNVQAAAPEENDAEEARTRSTPSPLVKEDRAADRDRAKGVLELYDDSDW--- 989

Human   666 TEEL-IESPK------LESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIATCDTFGNEDFNN 723
             ||| |:.||      |..:|.::  :..|...|.|.               :..||....|.|.
  Fly   990 -EELDIDKPKEFEKALLTETEAQV--SPKRAPSKRPP---------------SKKDTSLERDVNE 1036

Human   724 I-QDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTEL-PKTHIEQIQKHFSEDNNEMIPMECD 786
            . .:.|.:......|:   ||:|.|:.|:.|.|..:... |||...::
  Fly  1037 SGSEHEQDRSYTPCLD---EKNLAEEEEAGTTHQNNVSTSPKTRSSKV----------------- 1081

Human   787 SFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMP----SSDLADEKVETVSQPSESPK-DTID 846
                ..:|.|.|.:|..|::..:|.:    :||..|    |...|:.|.:.....|:..| :|..
  Fly  1082 ----SGDEDEPEKAVGTDIQSEDELN----NENESPRRSRSRGTANNKKDKSKSRSKRNKGETFK 1138

Human   847 KT-KKPRTRRSRFHSPSTTWSPNKDTPQEKKRPQSPSPRRETGKESRKSQSPSPKNESARGRKKS 910
            |. |:.:.|..|........||..|:.....:.:|.|||  ..|...:|:|.|.....::...:|
  Fly  1139 KVGKRQKDRNYRGDKSEPDRSPRPDSRSLTPKMRSKSPR--VSKSISRSRSGSRSRCKSKSFSRS 1201

Human   911 RSQSPKKDIARERRQSQSRSPKRDTTRESRRSESLSPRRET------------------------ 951
            ||:||.:...|.||.|:|:|..|..:|...||.|.|.:|.:
  Fly  1202 RSRSPSRSRNRRRRNSRSKSYSRSHSRSRSRSNSHSRQRFSFRGRDHQRGFFRGRGGLRLNYRNQ 1266

Human   952 -------------------------------------------SRENKRSQPR--VKDSSPGEKS 971
                                                       .|..:|..||  |::.....:.
  Fly  1267 QFHNRPFQHYGQNYHQNQNYHHQHNQHQNYFPPNQHGQHQQYFQRPKRRELPRYDVRNVVGTSRH 1331

Human   972 RSQSRERESDRDGQRRERERRTRKWSRSRSHSRSPSRCRTKSKSSSFGRIDRDSYS--------- 1027
            ::|:::|.. ||..|..|.|..|:  .|||.|||.||....|..|..|...|.|:|
  Fly  1332 QTQAKDRYG-RDAMRSHRSRSGRR--NSRSFSRSVSRDSRVSLRSRSGSPKRRSFSMSPTPPPGT 1393

Human  1028 ---PRWKGRWANDGWRCPRGNDRYRKND---PEKQNENTRKEKNDIH---LDADDPN--SADKHR 1081
               |...||     .|....|.||.::.   |..:||........:|   ..:..||  :.|.:|
  Fly  1394 SPPPHKHGR-----GRQTSTNRRYARSPSPAPSPRNERATSPVQSVHSRRSRSHTPNRINGDGNR 1453

Human  1082 ND----CPNWITEKINSGPDPRTRNP----EKLKESHWEENRNENSGNS---------------- 1122
            :.    .|::......|....|:::|    :|.|:...::.|.:.:|:|
  Fly  1454 SSLYMGSPHYTPRISRSRSRSRSKSPKDMHKKKKKKSDKKKRRKRTGSSSPTTAARMRRISRQRD 1518

Human  1123 ------------------------W------------------NKNFGSGWVSNRGRGRG----N 1141
                                    |                  :||  |.|....|..:|    |
  Fly  1519 PFEDADDFLAPQRKRKKAGITTGQWSPSPSPGRCDFLHDSALQDKN--SSWTPPLGTPKGGHYNN 1581

Human  1142 RGRGTYRSSFAYKDQN------------------ENRWQNRKPL-------SGN----------- 1170
            .|..|.:.:...:|::                  :.|.|..:||       |||
  Fly  1582 DGGLTPKKTKRKRDKSKKKRKQHQLEKPRKEKKRKRRTQTPEPLPSKEVFASGNNILVSVSFNKE 1646

Human  1171 SNSSGSESFKFVEQQS-----------YKRKSEQEFSFDTPADRSGWTSASSWAVRKTL------ 1218
            ||::.:.:....:|||           ...:.....|..:.|..|...||.. ||:||.
  Fly  1647 SNTNNASATLSSQQQSVVTIPPGREDLLSNRMTSMTSMASMASNSNICSAVG-AVKKTKRKRKKL 1710

Human  1219 --------------------PADV----------QNYYSRR--------------GRNSSGPQSG 1239
                                ||||          :...|||              |:....||.|
  Fly  1711 EAKPVAIIDLERSPFQVHQEPADVIVLTDSEDATEPLSSRRERERDRDHELMRENGQREKTPQVG 1775

Human  1240 WMKQEEETSGQDSSLK------------------------------------------------- 1255
            .:....|||.::.:..
  Fly  1776 SLDAIMETSYENMTQSTGPKTPPEPPLVKFNLPTKKIQHKVRNNPLHEDVDDINSADELEASCSM 1840

Human  1256 ---DQTNQ----QVDGSQL------------------PIN------------MMQPQMNVMQQQM 1283
               :||.|    ..||.|.                  |..            .:.|..|:.||.:
  Fly  1841 APAEQTPQHGHASHDGGQKIGPNTPPESGPCSPDAYDPFEPTKSPSLSPRSPTLTPSQNLDQQTV 1905

Human  1284 N--------------------------------AQHQPMNIFPYPVGVHAPLMNIQRNPFNIHPQ 1316
            :                                ||...:|    ||.:...|||......:|..:
  Fly  1906 SMPASGAIGPGSGDKGESDGAHVTGSNASTNTQAQGNALN----PVDLVMALMNKPNQSGSIQQE 1966

Human  1317 -------------LPLHLHTGVP-----------------------------LMQVATPTSVSQG 1339
                         |.|.|..|..                             |:..::..|.||.
  Fly  1967 SEVSSAQYISSSSLSLSLGVGSSTGGGGGGAGGGDNHDKTADGKTITVLSNVLLTSSSVVSSSQH 2031

Human  1340 LPPPPPPPPPSQQVNYIASQPDGKQLQGIPSSSHVSNNMSTPVLPAPTAAPGNTGMVQGPSSGNT 1404
            :|....|.|||            |:|..:|.:.....:.|:.|...||.:.|..|...|...||.
  Fly  2032 IPSISSPTPPS------------KKLTPLPKAGGSVASSSSGVGNIPTTSSGIGGTRNGSGLGNA 2084

Human  1405 SSSSHS------------------------------KASNAA--------VKLAE---------- 1421
            ..||::                              :||..|        |::.:
  Fly  2085 GGSSNALDDSFSMEIESPYSPGSADYEDLFEPPIPLEASRRAKGGATGGKVEIFDNLFGSSSPIS 2149

Human  1422 -----SKVSVAVEASADSSKTDKKLQI-------------------------------QEKAAQE 1450
                 |:.:.||...::.:|.|:|.::                               ||:..:|
  Fly  2150 NIRMTSRYNTAVGKKSNRTKADRKSKVKGARNPDFYDDVPNSATDLQNKDRLLRKLNRQERVVEE 2214

Human  1451 VKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKSGEVNSTKVANLVKAYVDKYKYSRK 1509
            |||.:||::..|.|||::||:|:|:||.|:|||:|||:|..|:.||:.|||.|::...|
  Fly  2215 VKLVLKPYFNKKAITKDDYKDIMRRAVPKICHSRSGEINPHKIKNLIDAYVRKFRAKHK 2273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCAF11	XP_005269287.3	mRING-HC-C3HC3D_SCAF11	103..154	CDD:438298	21/50 (42%)
		PRK12678	822..>1073	CDD:237171	78/343 (23%)
CG2926	NP_649554.1	mRING-HC-C3HC3D_PHRF1	149..199	CDD:438297	20/49 (41%)
		PHD_PHRF1	246..291	CDD:277011	7/46 (15%)