DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BOC and robo1

DIOPT Version :10

Sequence 1:XP_047305129.1 Gene:BOC / 91653 HGNCID:17173 Length:1152 Species:Homo sapiens
Sequence 2:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster


Alignment Length:1269 Identity:279/1269 - (21%)
Similarity:424/1269 - (33%) Gaps:331/1269 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     6 MTAWRGMRPEVTLACLLLATAGCFADLNEV--PQVTVQPASTVQKPGGTVILGCVVE-PPRMNVT 67
            :.||        |..:|:|:.|..|...:.  |::...|...|.|......|.|.|| .|...:.
  Fly    32 LPAW--------LLLVLVASNGLPAVRGQYQSPRIIEHPTDLVVKKNEPATLNCKVEGKPEPTIE 88

Human    68 WRLNGKELNGSDDAL-------GVLITHGTLVITALNNHTVGRYQCVARMPAGAVASVPATVTLA 125
            |..:|:.::.::...       |.|..:.|:  ........|.|.|||:...|...|..|::.:|
  Fly    89 WFKDGEPVSTNEKKSHRVQFKDGALFFYRTM--QGKKEQDGGEYWCVAKNRVGQAVSRHASLQIA 151

Human   126 NLQ-DFKLDVQHVIEVDEGNTAVIACHLPESHPKAQ---VRYSVKQEWLEA----SRGNYLIMPS 182
            .|: ||:::.:.. .|.:|.||::.|..|:..|:..   ::..|..:.|:|    :.....|:..
  Fly   152 VLRDDFRVEPKDT-RVAKGETALLECGPPKGIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDG 215

Human   183 GNLQIVNASQEDEGMYKCAAYNPV-TQEVKTSGSSDRLRVRRSTAEAARIIYPPEAQTIIVTKGQ 246
            |||.|.|....|||.|||.|.|.| |:|    .|..:|.|:      .:..:..|.:..::..||
  Fly   216 GNLLISNVEPIDEGNYKCIAQNLVGTRE----SSYAKLIVQ------VKPYFMKEPKDQVMLYGQ 270

Human   247 SLILECVASGIPPPRVTWAKDGSSVTGYNKTRFL--LSNLLIDTTSEEDSGTYRCMADNGVGQPG 309
            :....|...|.|||:|.|.|:..::. .::.|.|  ..:|.|...:..|.|||.|.|.|.|||..
  Fly   271 TATFHCSVGGDPPPKVLWKKEEGNIP-VSRARILHDEKSLEISNITPTDEGTYVCEAHNNVGQIS 334

Human   310 AAVILYNVQVFEPPEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRR 374
            |...|.   |..||..|...|...:......:|.|...|||||||.|.:..|..:........|:
  Fly   335 ARASLI---VHAPPNFTKRPSNKKVGLNGVVQLPCMASGNPPPSVFWTKEGVSTLMFPNSSHGRQ 396

Human   375 ------ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTS----RPSPPGITPRLWQDAELATG 429
                  .|::..:..||||.|.|.|.:.|.|:...|.|:.|    ||                  
  Fly   397 HVAADGTLQITDVRQEDEGYYVCSAFSVVDSSTVRVFLQVSSLDERP------------------ 443

Human   430 TPPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYEL 494
             ||:                      ..:|||:...|    :|:.|..|.     |.:...|..:
  Fly   444 -PPI----------------------IQIGPANQTLP----KGSVATLPC-----RATGNPSPRI 476

Human   495 VWRPRHEGSGRAPILYYVVKHRKQVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNC- 558
            .|  .|:|            |..|..|...  .|.|.......|.|:  |.|:        |.| 
  Fly   477 KW--FHDG------------HAVQAGNRYS--IIQGSSLRVDDLQLS--DSGT--------YTCT 515

Human   559 -AGE-GQTAMVTFRTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSP---PEAPDRPTI 618
             :|| |:|:.....|..:|                       .|...|....|   |..|..|.:
  Fly   516 ASGERGETSWAATLTVEKP-----------------------GSTSLHRAADPSTYPAPPGTPKV 557

Human   619 STASETSVYVTWI-----PRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKG 678
            ...|.||:.:.|.     |...|  ||..:.|||........||:|...:..::  |.|:||..|
  Fly   558 LNVSRTSISLRWAKSQEKPGAVG--PIIGYTVEYFSPDLQTGWIVAAQRVGDTQ--VTISGLTPG 618

Human   679 TSYKFRVRALNMLGESEPSAPSRPY--------VVSGYSGRVYERPVAGPYITFTD--AVNETTI 733
            |||.|.|||.|..|.|.||..|...        ..|..........:.|..:...|  |:|.:.:
  Fly   619 TSYVFLVRAENTQGISVPSGLSNTIKTIEADFDAASANDLSAARTLLTGKSVELIDASAINASAV 683

Human   734 MLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFN 798
            .|:|| :..|.:...:.|..|:|:.....:...:...:::.......:.:|:..|.|:..:..|.
  Fly   684 RLEWM-LHVSADEKYVEGLRIHYKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFFLTPFF 747

Human   799 EGGESEFSNVMICETKARKSSGQPGRL---------------PPPTLAPPQPPLPETIERPVGTG 848
            |..|.:.||.....|.....|..|..:               |||:...........||...|..
  Fly   748 ETIEGQPSNSKTALTYEDVPSAPPDNIQIGMYNQTAGWVRWTPPPSQHHNGNLYGYKIEVSAGNT 812

Human   849 AMVARSSDLPYLIVGVVLGSIVLIIVTFI---------------PFCLWRAWSKQKHTTDLGFPR 898
            ..|..:..|......|:|.::....|..:               |..|:...:...|        
  Fly   813 MKVLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDPTHHVH-------- 869

Human   899 SALPPSCPYTMVPLGGLPG-HQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPG-MKPQQH-- 959
               ||...    |.|...| |:.....|             |.|...|      || :.|..|  
  Fly   870 ---PPRAH----PSGTHDGRHEGQDLTY-------------HNNGNIP------PGDINPTTHKK 908

Human   960 --------------C--------PGELQQAFFSQEQML------LLLSEDWKVT----------W 986
                          |        ...:...:|.::..:      |.:..|.::|          |
  Fly   909 TTDYLSGPWLMVLVCIVLLVLVISAAISMVYFKRKHQMTKELGHLSVVSDNEITALNINSKESLW 973

Human   987 TPRRGRLITLPFEQQSDTSSLLRQTHL------------GNGY---DPQSHQITRGPKSSPDEGS 1036
            ........|...::.|..|.....:|:            |..|   |.::.......:.|||..:
  Fly   974 IDHHRGWRTADTDKDSGLSESKLLSHVNSSQSNYNNSDGGTDYAEVDTRNLTTFYNCRKSPDNPT 1038

Human  1037 -FLYTL-------------------PDDSTHQLLQPHHDCCQRQEQPAAVGQSGVRRAPDSPV-- 1079
             :..|:                   .|..||   .|:.|....|.....|.:|...:.|..|:  
  Fly  1039 PYATTMIIGTSSSETCTKTTSISADKDSGTH---SPYSDAFAGQVPAVPVVKSNYLQYPVEPINW 1100

Human  1080 LEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVS 1113
            .|.:..||.|..|....|...    .||:|.:.|
  Fly  1101 SEFLPPPPEHPPPSSTYGYAQ----GSPESSRKS 1130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BOCXP_047305129.1 Ig_3 36..109 CDD:464046 18/80 (23%)
Ig 129..204 CDD:472250 25/81 (31%)
Ig strand B 146..150 CDD:409353 1/3 (33%)
Ig strand C 160..164 CDD:409353 0/6 (0%)
Ig strand E 183..187 CDD:409353 3/3 (100%)
Ig strand F 197..202 CDD:409353 3/4 (75%)
Ig 239..306 CDD:472250 21/68 (31%)
Ig strand B 248..252 CDD:409353 0/3 (0%)
Ig strand C 261..265 CDD:409353 1/3 (33%)
Ig strand E 276..286 CDD:409353 3/11 (27%)
Ig strand F 296..301 CDD:409353 3/4 (75%)
Ig 323..406 CDD:472250 26/88 (30%)
Ig strand B 340..344 CDD:409353 1/3 (33%)
Ig strand C 353..357 CDD:409353 2/3 (67%)
Ig strand E 374..378 CDD:409353 1/9 (11%)
Ig strand F 388..393 CDD:409353 2/4 (50%)
Ig strand G 401..404 CDD:409353 0/2 (0%)
ISET-FN3_linker 414..476 CDD:435475 7/61 (11%)
FN3 <474..>766 CDD:442628 74/312 (24%)
FN3 610..701 CDD:238020 34/95 (36%)
FN3 716..813 CDD:238020 19/98 (19%)
robo1NP_476899.1 Ig 56..151 CDD:472250 22/96 (23%)
Ig strand B 73..77 CDD:409353 1/3 (33%)
Ig strand C 86..90 CDD:409353 0/3 (0%)
Ig strand E 111..115 CDD:409353 2/3 (67%)
Ig strand F 129..134 CDD:409353 2/4 (50%)
Ig strand G 143..146 CDD:409353 1/2 (50%)
IgI_2_Robo 158..251 CDD:409389 29/97 (30%)
Ig strand A 158..161 CDD:409389 0/2 (0%)
Ig strand A' 163..167 CDD:409389 0/4 (0%)
Ig strand B 171..178 CDD:409389 3/6 (50%)
Ig strand C 186..191 CDD:409389 0/4 (0%)
Ig strand C' 193..196 CDD:409389 1/2 (50%)
Ig strand D 209..213 CDD:409389 0/3 (0%)
Ig strand E 216..222 CDD:409389 4/5 (80%)
Ig strand F 229..237 CDD:409389 5/7 (71%)
Ig strand G 240..251 CDD:409389 4/14 (29%)
IgI_3_Robo 258..341 CDD:409390 27/86 (31%)
Ig strand A 258..261 CDD:409390 0/2 (0%)
Ig strand A' 263..267 CDD:409390 0/3 (0%)
Ig strand B 270..279 CDD:409390 2/8 (25%)
Ig strand C 285..290 CDD:409390 2/4 (50%)
Ig strand C' 293..296 CDD:409390 0/2 (0%)
Ig strand D 299..304 CDD:409390 1/4 (25%)
Ig strand E 305..313 CDD:409390 2/7 (29%)
Ig strand F 320..328 CDD:409390 5/7 (71%)
Ig strand G 331..341 CDD:409390 4/12 (33%)
Ig 346..437 CDD:472250 26/90 (29%)
Ig strand B 362..366 CDD:409353 1/3 (33%)
Ig strand C 375..379 CDD:409353 2/3 (67%)
Ig strand E 402..406 CDD:409353 1/3 (33%)
Ig strand F 416..421 CDD:409353 2/4 (50%)
Ig strand G 429..432 CDD:409353 0/2 (0%)
Ig 446..531 CDD:472250 27/141 (19%)
Ig strand B 462..466 CDD:409544 1/3 (33%)
Ig strand C 475..479 CDD:409544 1/5 (20%)
Ig strand E 497..501 CDD:409544 0/3 (0%)
FN3 507..>916 CDD:442628 99/480 (21%)
Ig strand F 511..516 CDD:409544 2/12 (17%)
Ig strand G 524..527 CDD:409544 0/2 (0%)
FN3 549..637 CDD:238020 32/91 (35%)
fn3 770..855 CDD:394996 12/84 (14%)

Return to query results.
Submit another query.