DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PCSK7 and Fur2

DIOPT Version :9

Sequence 1:	NP_004707.2	Gene:	PCSK7 / 9159	HGNCID:	8748	Length:	785	Species:	Homo sapiens
Sequence 2:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	284/876 - (32%)
Similarity:	412/876 - (47%)	Gaps:	190/876 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    35 VMGLAGTGGPDGQGTGGPSWAVHLE------------------SLEGDG---------EEETL-- 70
            ::||.|......:...|..:..:.|                  ||:.||         .||.:
  Fly   176 LVGLGGERAGQAETISGGKYDYNYENTHTNASAKDEIVERQSNSLDFDGVDMFGAFSIPEEAIYT 240

Human    71 ----------EQQADALAQAAGLVNAGRIGELQGHYLFV----------QPAGHRPAL----EVE 111
                      :|.||.:|...|.:|.|:||.|..:|||.          ....|:.||    ||:
  Fly   241 NEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVK 305

Human   112 AIRQQVEAVLAGHEAVR-----------WHSEQRLLRR------------------------AKR 141
            .::||       ||.||           .:|...|||:                        ::|
  Fly   306 WMQQQ-------HEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQR 363

Human   142 ------SVH--FNDPKYPQQWHL---NNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQ 195
                  |.|  |.||.:.:||:|   |.....|.|:||...|::..||:||.|.::|||::....
  Fly   364 MEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHP 428

Human   196 DIAPNYSPEGSYDLNSNDPDPMPHPDVENG-NHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIR 259
            |:|.||.||.|:|:|.||.||.|.   :|| |.||||||||:|||..|:||.|||||.:.|.|:|
  Fly   429 DLAQNYDPEASFDINGNDSDPTPQ---DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVR 490

Human   260 VLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGFGSIFV 324
            :|||.:.|.:||.|.:.:....||||.||||:|||.|||||..|.:.|..:||.:||||.|||||
  Fly   491 MLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFV 555

Human   325 VASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGG----DKMLRSI 385
            .||||||::.|:||.|||.|||:|::|.:..:.|..|:|.|||:|.||.|:|.|    ||   |:
  Fly   556 WASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDK---SV 617

Human   386 VTTDWD--LQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYE-DRRA 447
            .|.|.|  |:....||..||||||:||||||:.||.|:..|.|||||:|:::|:|:.... ::..
  Fly   618 ATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKEN 682

Human   448 EWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAIPQSPRS-LEVLWN 511
            .|..|.....:||:.|:||::|..:|:.|:.|||||......|....|::.|..:..| |....:
  Fly   683 GWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMD 747

Human   512 VSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFST 576
            |:.....::.::.||||...:::....||:|.:.|..|.|..|.:...|..|...:.|:||.|.:
  Fly   748 VNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLS 812

Human   577 VRCWGERARGTYRLVIRDVGDESF-QVGILRQWQLTLYGSVWSAVDIRDRQRLLESA--MSGKYL 638
            |..|||:|.|.:.|.:.:.|.... |.|||.:|||..||:  |...:|.:..||.|:  :.....
  Fly   813 VHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGT--STQPMRLKSELLNSSPQLRSPSS 875

Human   639 HDDFALPCPPGLKIPEEDGYTITPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGP 703
            .:.|..|....:..|..:|.....::..:                   ||:.:|:.|:
  Fly   876 SNPFLFPSASNIGQPANEGGNFNTDSFAS-------------------YLNYQNIFSS------- 914

Human   704 CHWPHRSRKAKEEGTELESVPLCSSKDPDEV--------ETESRG-PPTTSDLLAPDLLEQGDWS 759
                        .|::.|  |..::.|...|        ..||.| ..:.:.|:|......||..
  Fly   915 ------------AGSDPE--PATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAAPETRDGDKK 965

Human   760 LSQNKSA---------------LDCPHQHLD 775
            :..:..|               :.|.|..||
  Fly   966 ILHSCDAECDSSGCYGRGPTQCVACSHYRLD 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PCSK7	NP_004707.2	S8_pro-domain	53..141	CDD:293079	35/175 (20%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..440	CDD:173789	157/304 (52%)
		Peptidase_S8	196..441	CDD:278510	137/251 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..219		12/21 (57%)
		P_proprotein	525..612	CDD:279782	32/87 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..751		10/59 (17%)
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	24/82 (29%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	157/304 (52%)
		Peptidase_S8	411..700	CDD:278510	149/294 (51%)
		P_proprotein	761..849	CDD:279782	32/87 (37%)
		Furin-like	966..1126	CDD:279142	5/31 (16%)
		FU	970..1013	CDD:238021	5/27 (19%)
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720