DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLXNA4 and PlexA

DIOPT Version :10

Sequence 1:NP_065962.1 Gene:PLXNA4 / 91584 HGNCID:9102 Length:1894 Species:Homo sapiens
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:1979 Identity:831/1979 - (41%)
Similarity:1150/1979 - (58%) Gaps:196/1979 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    26 LTRQPAPLSQKQRSFVTFRGEPA--EGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGP 88
            ||...||:...:....|.....|  ...|||:||..||.:::|.|||:|:||.||::..|.:|||
  Fly    48 LTNANAPIKNAKNLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGP 112

Human    89 DEDNPKCYPPRIVQTC--NEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGE 151
            ..|:.:|    .:..|  |...:.|:|.||:||||...:||||||||:||.|.:..|:::..:  
  Fly   113 QNDSVEC----SILDCPLNAVRSPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-- 171

Human   152 PYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEY--------------------- 195
                 ||.:..        .|:.:.:|.....|||   .|.|::                     
  Fly   172 -----EHEVPD--------AVVANDANSSTVAFIA---PGPPQHPVTNVMYVGVTYTNNSPYRSE 220

Human   196 FPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFD-----IYYVYGFSSGNFVY 255
            .|.::||.|.|..    ||.       :||. .:.:.|.|.|..:.     :.|||||||..|.|
  Fly   221 IPAVASRSLEKTK----MFQ-------IASS-AVTTGTRTFINSYARETYFVNYVYGFSSERFSY 273

Human   256 FLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC---ERSGVEYRLLQAAYLSK 317
            |||.|  :.....|:.||  |.:||||:|:||:.:.||.|:|:.|   .:.|.::.|:||.:|.|
  Fly   274 FLTTQ--LKHSHHSSPKE--YITKLVRICQEDSNYYSYTEIPVECISDAQGGTKFNLVQAGFLGK 334

Human   318 AGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLD 382
            ..:.|.::||:...||:||.|||||:..  ...:.|||||:.||.|..:..:.::||:.|.|...
  Fly   335 PSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNNSALCIYSLKSIRRKFMQNIKSCFNGSGMRG 397

Human   383 LAWLKVKDIPC-SSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLA 446
            |.::. ..:|| .:.|.||.::|||||:|:|||....:..:|| .....::|||.|.....:::.
  Fly   398 LDFIS-PSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSVPV-AMFNTKLTSVAATSTSGYTVV 460

Human   447 FVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCG 511
            ||||..|.|||:.::. ...|.:|.:..|.....:.|||.|...:..:|:||:.::::|.|..|.
  Fly   461 FVGTSDGFLKKVVIES-SSIANEYASFAVDLGSEINRDMQFDNQNLYIYVMSKTKVSKVKVFDCS 524

Human   512 QYQSCGECLGSGDPHCGWCVLHNTCTRKERC-ERSKEPRRFAS-EMKQCVRLT-VHPNNISVSQY 573
            .|::||:|||:.||:||||.|.|.|:.:..| :.:.:|..:.| :..:|..:| |.|:.:..:..
  Fly   525 DYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTITSVVPHQLQRTTA 589

Human   574 NVL-LVLETYNVPELSAGVNCTFEDLSEMDGLVVG-----NQIQCYSPAAKEVPRIITENGDHH- 631
            ..| |:::  ::|:|...:.|.|  .:|...|...     |.:.|.:|....:|:|  |.|.|| 
  Fly   590 RTLELIID--HLPQLKENLICAF--TTEDKALFTNATKKRNGVNCTTPRTDMLPQI--EQGKHHF 648

Human   632 VVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTHD-PKTC------- 688
            ..:|.:::: .|....||.|.|::||.|:||..||.|.:.|.||...|.|||| .:.|       
  Fly   649 TAKLSVRTR-NGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILVT 712

Human   689 -------SFQEGRVKLPEDCPQLLRV---DKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNI 743
                   |::.|    |..||.:...   .::||.....|.|.:|...:.| ...|..:.|..||
  Fly   713 GVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQ-FIVQTRFVCQFNI 772

Human   744 QGSEQRVPAL--RFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGA 806
            :|   ||.:|  :....::.|.:..:.|.... .||.....|:|.|...:|||....|.:|:|..
  Fly   773 EG---RVTSLNAQLLGDTIYCDSMEFQYTSRS-PNLTATFAVIWGGSKPLDNPHNIHVVIYRCRE 833

Human   807 MRESCGLCLKADPDFACGWCQGPGQCTLRQHCPAQ---ESQWLELSGAKSKCTNPRITEIIPVTG 868
            |.:|||:||.....:.||||.....|.:.:.|...   ::.||..|   ..|.||.|....|.||
  Fly   834 MADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRS---EICPNPEIHTFQPKTG 895

Human   869 PREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCEM---GEAKPSQHAGFV 930
            |.||||.:||||.|||..:.||.|.|::||:.|.|....||..:||||.:   ||.........|
  Fly   896 PWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVV 960

Human   931 EICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQ-PC 994
            :|      .::...|.:.|.|:...:.|..|..||.||||::.|||.:|||||.:....... ||
  Fly   961 QI------GDYRGESKEDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPC 1019

Human   995 LFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRA-KIHQDLVFQYVEDPTIVRIE---------PEW 1049
            .......|..:|.|::|..::|.::.:..|.. :...|..|:||.|||:..:.         |: 
  Fly  1020 KILSTDSSQAICRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPK- 1083

Human  1050 SIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVLNATEMTCQAPALALGPDHQSDLTER 1114
            .|.:|...|:|.||....||||.|...:.|:.:.:.|.|.:.|||.|.:|.:.:  |......||
  Fly  1084 GIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQSDTEMECASPVVDV--DSHVIEAER 1146

Human  1115 P--EEFGFILDN---VQSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAG 1174
            |  .|:||::||   ||:|..::..:|..||||.:..|...  ::......:.:.|:||......
  Fly  1147 PILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEER--VKYFKSEYLTINGRNLDRACKE 1209

Human  1175 GNVKLNYTVLVGEKPCTVT-VSDVQLLCESPN------LIGRHKVMARVG-GMEYSPGMV-YIAP 1230
            .:|:    |.:|...|.:| :|..||.|..|:      .:...:|:.|:| .:||..|:: |.:.
  Fly  1210 SDVE----VKIGNGFCNITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSLEYRIGILSYESS 1270

Human  1231 DSPLSLPAIVSIAVAGGLLIIFI--VAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAF 1293
            :..|.....|..||...::|:.:  ||:|:|||:||.||...|:.:|.|||.||.|||.||||||
  Fly  1271 NIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSESSRVLRNMQEQMDILELRVAAECKEAF 1335

Human  1294 AELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQE--RVEKGLKLFA 1356
            |||||::.:||.||...||||||||:|.|::|||..|||.||:     ..|.|  |.||||::|.
  Fly  1336 AELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDHIVLQ-----WERPELLRKEKGLRIFG 1395

Human  1357 QLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKN 1421
            |||.||.|||.|||||||.|.||||:|.|||||||..|||||||.||:||.||.|||:|.:|.|:
  Fly  1396 QLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLEYCTDILKTLLGDLIEKCIEGKS 1460

Human  1422 HPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLS 1486
            |||||||||||||||||:.||||||||||||||||||:.||.|:|.|::|||:||.|.|||||||
  Fly  1461 HPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRAVKGQVDKGPVDACTHEARYSLS 1525

Human  1487 EDKLIRQQIDYKTL---------VLSCVSPD--NANSPEVPVKILNCDTITQVKEKILDAIFKNV 1540
            |:|||||.||::.:         .:.|.:.|  .:::..|.||:|:||||.|||||.|:.|::|:
  Fly  1526 EEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSHTENVSVKVLDCDTIGQVKEKCLETIYRNI 1590

Human  1541 PCSHRPKAADMDLEWRQGSGARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAY 1605
            |.|.||:..|:|||||.|:..|:||.|||:|:|.|::||:||||.||.||||:.::||.||.:.|
  Fly  1591 PSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKLNTLQHYNVPDGAGLSLVPKQSSIY 1655

Human  1606 NAVNNSTVSRTSASKYE--NMIRYT-GSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGD 1667
            |....|..:..| .|||  |:.:|| .||...|:.:|:.....|:|::.|||||:|:...||||:
  Fly  1656 NFSILSDKNEKS-HKYETLNISKYTSSSPTFSRAGSPLNNDMHENGLRYWHLVKHHDSDMQKEGE 1719

Human  1668 RGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDP 1732
            |.:|:|||||||||||||||||||||||||||||||||||||||||||||||||:||..|||.||
  Fly  1720 RVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDDQAQLHGITDP 1784

Human  1733 HVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNK 1797
            .|.||||||.||||||||:||||.|||||||::|.|:||||||||||||||||:|||||||||:|
  Fly  1785 EVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVVAQTFMDSCSTSDHRLGKDSPSSK 1849

Human  1798 LLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSE 1862
            ||||||||.|:.||:|||.||..|..||||||||.|||:||:|..||||..||.|:::|..||:|
  Fly  1850 LLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRLHTTEFNTNCALHELYTYAVKYNE 1914

Human  1863 EILGPLDHDDQCGKQKLAYKLEQVITLMS 1891
            ::...|:.|:...||:||:|||||..:||
  Fly  1915 QLTVTLEEDEFSQKQRLAFKLEQVHNIMS 1943

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXNA4NP_065962.1 Sema_plexin_A4 39..511 CDD:200535 167/505 (33%)
PSI 510..548 CDD:214655 17/38 (45%)
TIG_plexin 564..654 CDD:465588 23/96 (24%)
PSI 655..702 CDD:396154 20/61 (33%)
TIG_2 708..802 CDD:465619 25/95 (26%)
PSI 804..856 CDD:396154 16/54 (30%)
IPT_plexin_repeat1 858..953 CDD:238585 38/97 (39%)
IPT_plexin_repeat2 955..1038 CDD:238584 27/84 (32%)
IPT_plexin_repeat3 1040..1140 CDD:238586 35/113 (31%)
IPT_PCSR 1142..1222 CDD:238337 19/87 (22%)
Plexin_cytopl 1311..1859 CDD:462434 365/563 (65%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 164/487 (34%)
PSI 522..574 CDD:396154 19/51 (37%)
TIG_plexin 580..670 CDD:465588 23/96 (24%)
PSI 671..>702 CDD:396154 16/30 (53%)
TIG_2 738..829 CDD:465619 25/95 (26%)
PSI 830..883 CDD:396154 16/55 (29%)
IPT_plexin_repeat1 885..977 CDD:238585 38/97 (39%)
IPT_plexin_repeat2 978..1063 CDD:238584 26/84 (31%)
IPT 1078..1177 CDD:472823 33/101 (33%)
TIG <1196..>1246 CDD:460355 13/53 (25%)
Plexin_cytopl 1353..1911 CDD:462434 365/563 (65%)

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