Protein Alignment SLC28A2 and CNT2

DIOPT Version :9

• Sequence 1: NP_004203.2
• Gene: SLC28A2 / 9153
• HGNCID: 11002
• Length: 658
• Species: Homo sapiens
• Sequence 2: NP_610446.1
• Gene: CNT2 / 35914
• FlyBaseID: FBgn0025709
• Length: 603
• Species: Drosophila melanogaster
• Alignment Length: 603
• Identity: 232/603 - (38%)
• Similarity: 345/603 - (57%)
• Gaps: 67/603 - (11%)

Human    18 GTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCK-THASLFKKIL 81
            |.:|.|.||..||::...|:  :...|.|.|    ::.....:..|.|.....: ...|::  :|
  Fly     8 GAINNGYELDHKELDIRDSE--EFTEHPLDD----TSEVANKKGYFEKNPKVARLVRISIY--VL 64

Human    82 LGLLCLAYAAYLL----------------AACILNFQRALALFVITCLVIFVLVHSF----LKKL 126
            |.|..:.|.:|..                ..|.:||.....:.::  |:.|:.:..|    .|.:
  Fly    65 LHLCVVGYFSYATYHYHDITNYECYWKDNPLCGINFCTGYGMLLL--LLGFIYLGLFYYYVFKPM 127

Human   127 LGKKLTR-CLKPFEN-----SRLRLWTKWVFAGVSLVGLILWLAL-------DTAQRPEQLIPFA 178
            :|..|.| .:|||..     ||.|:        |||..:.|.|||       :.....::|:...
  Fly   128 VGHSLHRNYIKPFSKKWHNFSRTRV--------VSLASIALLLALLAIFVYFECRDETQKLVSLV 184

Human   179 GICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAG 243
            ..|.|||..:..|.:..|::||.|.:|:..||:.||..||.::|..:|:.||.:|..||.|...|
  Fly   185 APCFFILCGYVFSTNRRAINWRIVITGITCQFLLGIFCIRWEVGRKIFECLGNKVATFLGYATDG 249

Human   244 SSFVFGDTLV-KDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVA 307
            :.|||||.|| .:||||..||:|.||...:|||||:|.:||||.|:.|.||..:|||..|::..|
  Fly   250 AEFVFGDFLVNNNVFAFAILPVIFFFSFFISILYYMGTMQWVVIKLGWILQQILGTTVCESVTAA 314

Human   308 GNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPC 372
            .|||:||:|:|||||||:..:|.||||::|..||||:|||||.|:::||..|:.||::||||||.
  Fly   315 ANIFLGMSESPLLIRPYINKLTKSEIHSIMVSGFATVSGTVLAAYLSFGASAAHLITSSVMAAPA 379

Human   373 ALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFI 437
            .||.|||..||.|||: .|.:.::|.:.::.::|:|||:||.:|:.:...:.||::||:|.:||:
  Fly   380 TLAISKLYMPETEESQ-TSSDSIELEKSQDSSLLDAASSGASNAVPIVLGIIANIVAFVAFIAFL 443

Human   438 NAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQY 502
            |..:||.|.||.::.:.|:.|.|.|..|:|:.|||...||.::|::|..|..|||||||::|.||
  Fly   444 NGLVSWFGYLVGLEQIDFEWIFSKLFIPLVWAMGVPKEDCDIIAKVVATKTIINEFVAYERLGQY 508

Human   503 KNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRA 567
                       ||...  |:.|:..|.||::|||||.||:||.:|.|:::.|||:|.::.|..||
  Fly   509 -----------IENND--ITARSAGIATFAICGFANPSSLGILIGSLSAMAPHRRSTITAVAFRA 560

Human   568 LFTGACVSLISACMAGIL 585
            ...|:.|..:||..||||
  Fly   561 FVVGSIVCFVSASFAGIL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC28A2	NP_004203.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		11/36 (31%)
		nupC	174..585	CDD:273278	188/411 (46%)
CNT2	NP_610446.1	nupC	180..578	CDD:273278	188/411 (46%)
		Nucleos_tra2_N	187..254	CDD:280026	26/66 (39%)
		Gate	268..363	CDD:284976	53/94 (56%)
		Nucleos_tra2_C	368..578	CDD:284970	95/223 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156998
Domainoid	1	1.000	188	1.000	Domainoid score	I3309
eggNOG	1	0.900	-	-		E1_COG1972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2083
Isobase	1	0.950	-	0	Normalized mean entropy	S5202
OMA	1	1.010	-	-		QHG63093
OrthoDB	1	1.010	-	-		D251221at33208
OrthoFinder	1	1.000	-	-		FOG0001233
OrthoInspector	1	1.000	-	-		mtm8645
orthoMCL	1	0.900	-	-		OOG6_102197
Panther	1	1.100	-	-	O	PTHR10590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4851
SonicParanoid	1	1.000	-	-		X691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750