DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ANKRD44 and HOS4

DIOPT Version :9

Sequence 1:	NP_001354424.1	Gene:	ANKRD44 / 91526	HGNCID:	25259	Length:	1074	Species:	Homo sapiens
Sequence 2:	NP_012154.1	Gene:	HOS4 / 854694	SGDID:	S000001374	Length:	1083	Species:	Saccharomyces cerevisiae

Alignment Length:	944	Identity:	195/944 - (20%)
Similarity:	330/944 - (34%)	Gaps:	276/944 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    33 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLH---RAVASRSEEAVQVLI 94
            :::.:|..|...|..:.|.|.:..::      ...|...||..:|..   |...|||
Yeast   253 ELSDIDDSKNIALSSSLFRGGSSPVK------ETNNNLSNMNSSPAQNPKRGSVSRS-------- 303

Human    95 KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 159
                    .|.|..:  |:|.:.:         |........|.||||.|..|...|..::|..:
Yeast   304 --------NDSNKSS--HIAVSKR---------PKQKKGIYRDSGGRTRLQIACDKGKYDVVKKM 349

Human   160 LAKGA-NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK--DKKGYTPLHAAASNGQINV 221
            :.:|. :||..|.....|||.||..||:::|.|||.:||:|..|  :..|.|||..|::||.::|
Yeast   350 IEEGGYDINDQDNAGNTALHEAALQGHIEIVELLIENGADVNIKSIEMFGDTPLIDASANGHLDV 414

Human   222 VKHLLNLGVEIDEINVYGNTA-------------------------LHIAC--YNGQDAVVNELI 259
            ||:||..|.:....|..|.||                         |.||.  :..:..:.|:..
Yeast   415 VKYLLKNGADPTIRNAKGLTAFESVDDESEFDDEEDQKILREIKKRLSIAAKKWTNRAGIHNDKS 479

Human   260 DYGAN---VNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD------VNIQSKDGKSPLHMTAV 315
            ..|.|   ::||..:..|......|:...::...  ::..|.      .::.|:.||..|...:.
Yeast   480 KNGNNAHTIDQPPFDNTTKAKNEKAADSPSMASN--IDEKAPEEEFYWTDVTSRAGKEKLFKASK 542

Human   316 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAA 380
            .|......|.::|||:||                         :.|..::.|||
Yeast   543 EGHLPYVGTYVENGGKID-------------------------LRSFFESVKCG----------- 571

Human   381 LNAHSDCCRKLLSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRT-CLHAAAAGGNVECIKLLQS 444
               |.|             |.|:|     |:.||.::...:..:| .|..|...|::..:|||..
Yeast   572 ---HED-------------ITSIF-----LAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLE 615

Human   445 SGADFHKKDKCGRTPLHYAAANC-------HFHCIETLVTT-----GANVNETDDWGRTALHYAA 497
            :|||..|:||.|||.|:||..:.       ....||..:..     ..:.|:.||
Yeast   616 AGADPTKRDKKGRTALYYAKNSIMGITNSEEIQLIENAINNYLKKHSEDNNDDDD---------- 670

Human   498 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKE-----------GY 551
              |.|.|.             |..:..|::|.|.......:..|.|.|.|:|           .:
Yeast   671 --DDDNNN-------------ETYKHEKKREKTQSPILASRRSATPRIEDEEDDTRMLNLADDDF 720

Human   552 NSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 616
            |:        .|...|.....:....:::::..|:..|.......:....|..|:|:..|.:...
Yeast   721 NN--------DRDVKESTTSDSRKRLDDNENVGTQYSLDWKKRKTNALQDEEKLKSISPLSMEPH 777

Human   617 KGRTALDLAAFKGHTECV---EALINQGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 678
            ..:.|..:...|.|.|..   ||.:.:... :.|..:.|:.....          .||.::|::
Yeast   778 SPKKAKSVEISKIHEETAAEREARLKEEEE-YRKKRLEKKRKKEQ----------ELLQKLAED- 830

Human   679 EAVDVKDAKGQTPLMLAVAYGHIDAVSL----LLEKEANVDTVDILGCTALHRGIMTGHEECVQM 739
            |...:::.:.|..|.:.    .::..:|    .:|:|..::.:              .:...|:.
Yeast   831 EKKRIEEQEKQKVLEME----RLEKATLEKARKMEREKEMEEI--------------SYRRAVRD 877

Human   740 LLEQEVSIL----CKDSRGRTPLHYAAARGHATWLSELLQMALSEE-DCCFKDNQ---------- 789
            |....:.|:    ..|.:...||:|.....:..::.:|..|.|.:: |...||||
Yeast   878 LYPLGLKIINFNDKLDYKRFLPLYYFVDEKNDKFVLDLQVMILLKDIDLLSKDNQPTSEKIPVDP 942

Human   790 -GYTPLHW----------ACYNGNENCIE----------VLLEQKC------FRKFIGNPFTPLH 827
             ..||| |          ..|:..:|.:|          |.|:.|.      ::||:..|...:.
Yeast   943 SHLTPL-WNMLKFIFLYGGSYDDKKNNMENKRYVVNFDGVDLDTKIGYELLEYKKFVSLPMAWIK 1006

Human   828 C--AIINDHGNCASLLLGAIDSSI---VSCRDDK 856
            .  .:|.:|.....:....|..||   ...|:||
Yeast  1007 WDNVVIENHAKRKEIEGNMIQISINEFARWRNDK 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ANKRD44	NP_001354424.1	ANK 1	7..36		0/2 (0%)
		ANK 2	40..69		4/28 (14%)
		ANK 3	73..102		6/31 (19%)
		ANK 4	106..135		4/28 (14%)
		ANK 5	139..168		10/29 (34%)
		ANK 6	172..201		14/28 (50%)
		ANK 7	205..234		13/28 (46%)
		ANK 8	238..267		9/58 (16%)
		ANK 9	271..301		3/35 (9%)
		ANK 10	305..334		9/28 (32%)
		ANK 11	338..367		1/28 (4%)
		ANK 13	422..451		10/29 (34%)
		ANK 14	455..484		8/40 (20%)
		ANK 15	488..516		3/27 (11%)
		ANK 16	549..579		4/40 (10%)
		ANK 17	584..613		6/28 (21%)
		ANK 18	617..646		6/31 (19%)
		ANK 19	651..680		4/28 (14%)
		ANK 20	687..716		5/32 (16%)
		ANK 21	720..749		3/32 (9%)
		ANK 22	753..782		6/29 (21%)
		ANK 23	789..818		11/65 (17%)
		ANK 24	821..850		6/33 (18%)
		ANK 25	856..885		1/1 (100%)
		ANK 26	889..919
		ANK 27	923..952
		ANK 28	959..988
HOS4	NP_012154.1	ANK repeat	330..361	CDD:293786	10/30 (33%)
		Ank_2	334..429	CDD:403870	36/94 (38%)
		ANK repeat	363..396	CDD:293786	15/32 (47%)
		ANK repeat	398..429	CDD:293786	13/30 (43%)
		Ank_2	537..624	CDD:403870	31/143 (22%)
		ANK repeat	592..624	CDD:293786	11/31 (35%)
		Ank_2	598..>656	CDD:403870	20/57 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910