DRSC/TRiP Functional Genomics Resources

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Protein Alignment ANKRD44 and AKR2

DIOPT Version :9

Sequence 1:NP_001354424.1 Gene:ANKRD44 / 91526 HGNCID:25259 Length:1074 Species:Homo sapiens
Sequence 2:NP_014677.1 Gene:AKR2 / 854199 SGDID:S000005560 Length:749 Species:Saccharomyces cerevisiae


Alignment Length:266 Identity:73/266 - (27%)
Similarity:117/266 - (43%) Gaps:33/266 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    84 SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 148
            |.:|..|.:.|:.:.|.:.               |.||  :|:......:|.......:.||.|.
Yeast    45 SNTEYVVDIFIEAAKDGDL---------------KVVK--DVVESGAVDINNDRIDELSGLHWAC 92

Human   149 LNGHVEMVNLLLAKGANIN-AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 212
            :|....:...||.:|||.| |.......||||||..|::.:|.||:.|||:.|.||::|...:|.
Yeast    93 INNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHF 157

Human   213 AASNGQINVVKHLL------NLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 271
            :..:..|.:|.::|      |..|:||..:....|.|..|.|.|....|..|:.:|:.|...:|.
Yeast   158 SVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNR 222

Human   272 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRS--QTLIQNGGEIDC 334
            ||..||.|.......:..:|:: :||  |...::.:.........|..|:|  :..:|:.|    
Yeast   223 GFNALHCALVGGDQRVICDLIL-SGA--NFYERNNQKQDCFDLAEGMGTKSLFEQALQHHG---- 280

Human   335 VDKDGN 340
            .|:.||
Yeast   281 YDRLGN 286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ANKRD44NP_001354424.1 ANK 1 7..36
ANK 2 40..69
ANK 3 73..102 5/17 (29%)
ANK 4 106..135 4/28 (14%)
ANK 5 139..168 10/29 (34%)
ANK 6 172..201 13/28 (46%)
ANK 7 205..234 8/34 (24%)
ANK 8 238..267 9/28 (32%)
ANK 9 271..301 8/29 (28%)
ANK 10 305..334 5/30 (17%)
ANK 11 338..367 2/3 (67%)
ANK 13 422..451
ANK 14 455..484
ANK 15 488..516
ANK 16 549..579
ANK 17 584..613
ANK 18 617..646
ANK 19 651..680
ANK 20 687..716
ANK 21 720..749
ANK 22 753..782
ANK 23 789..818
ANK 24 821..850
ANK 25 856..885
ANK 26 889..919
ANK 27 923..952
ANK 28 959..988
AKR2NP_014677.1 ANKYR 1..195 CDD:223738 47/166 (28%)
ANK repeat 54..81 CDD:293786 7/43 (16%)
ANK repeat 83..115 CDD:293786 11/31 (35%)
ANK repeat 117..148 CDD:293786 14/30 (47%)
ANK repeat 189..220 CDD:293786 9/30 (30%)
Ank_4 190..243 CDD:372654 15/52 (29%)
ANK repeat 222..247 CDD:293786 6/25 (24%)
COG5273 340..711 CDD:227598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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